A “signal-on” photoelectrochemical biosensor utilizing in-situ synthesis of SnS2/MgIn2S4 heterostructures and enzyme-assisted target cycling amplification for the sensitive detection of the mecA gene

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128053 - 128053

Published: March 1, 2025

Language: Английский

Nanoconfinement Effect and Nanozyme Catalysis Enhance ILu/HOF-14 Electrochemiluminescence for Biosensing

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

A low collision frequency and an insufficient number of free radicals are the main problems leading to electroluminescence (ECL) efficiency luminol its derivatives. In order solve above issues, this work used nanoconfinement combined with nanozyme catalysis significantly enhance ECL efficiency. We assembled isoluminol (ILu) into hydrogen-bonded organic framework HOF-14 prepared a novel emitter ILu/HOF-14 for first time. Surprisingly, compared ILu/H2O2 system, signal ILu/HOF-14/H2O2 was increased by 33 times. This because porous structure effectively limited movement their frequency. Therefore, reaction rate between improved achieve amplification. To further increase radicals, we introduced hybrid Zn SAC@CuO2 NPs superior peroxidase (POD)-like activity. It could catalyze coreactant H2O2 produce large amount ROS (OH• O2•-), accelerating ILu improving signal. Based on research, dual-mode biosensing imaging platform constructed detect microcystin-LR (MC-LR). nonspecific trans-cleavage activity CRISPR-Cas12a system dynamic continuity amplification capability platform, detection sensitivity broadening avenues molecular diagnostic strategies.

Language: Английский

Research on the application of metal-organic framework (MOF)-based nanozymes in colorimetric and electrochemical detection of biomolecules

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114752 - 114752

Published: May 1, 2025

Language: Английский