One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging DOI
Shengxiang Fu, Muhammad Rizwan Younis,

Zhongyuan Cai

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14252 - 14262

Published: Oct. 14, 2024

Traditional macromolecules or nanoscale Mn2+ chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability T1 relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert chelate-backboned polymers, P(MnL-PEG), through facile one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates significantly higher relaxivity 23.9 Mn mM–1 s–1 at 1.5 T than that previously reported small molecules CAs. Due to its high extended blood circulation, hepatocyte-specific uptake, kidneys metabolism, presents enhanced in vessel, liver, compared Gd3+-based CAs (Gd-EOB-DTPA Gd-DOTA) dosage 0.05 mmol Mn/Gd kg–1 BW, can accurately diagnose orthotopic H22 liver tumors vivo animal models. We anticipate this work will promote the development clinically relevant MRI

Language: Английский

One-Pot Fabrication of Kinetically Inert Ultrasmall Manganese(II) Chelate-Backboned Polymer Contrast Agents for High-Performance Magnetic Resonance Imaging DOI
Shengxiang Fu, Muhammad Rizwan Younis,

Zhongyuan Cai

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14252 - 14262

Published: Oct. 14, 2024

Traditional macromolecules or nanoscale Mn2+ chelate-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from complicated and laborious synthesis processes, relatively low kinetic stability T1 relaxivity, limiting their clinical applications. Herein, we fabricated a series of kinetically inert chelate-backboned polymers, P(MnL-PEG), through facile one-pot polymerization process. Particularly, P(MnL-PEG)-3 demonstrates significantly higher relaxivity 23.9 Mn mM–1 s–1 at 1.5 T than that previously reported small molecules CAs. Due to its high extended blood circulation, hepatocyte-specific uptake, kidneys metabolism, presents enhanced in vessel, liver, compared Gd3+-based CAs (Gd-EOB-DTPA Gd-DOTA) dosage 0.05 mmol Mn/Gd kg–1 BW, can accurately diagnose orthotopic H22 liver tumors vivo animal models. We anticipate this work will promote the development clinically relevant MRI

Language: Английский

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