Foldable Bulk Anti-adhesive Polyacrylic Intraocular Lens Material Design and Fabrication for Posterior Capsule Opacification Prevention DOI
Dong Liu,

Junmei Tang,

Liangliang Shen

et al.

Biomacromolecules, Journal Year: 2022, Volume and Issue: 23(4), P. 1581 - 1591

Published: March 10, 2022

Posterior capsular opacification (PCO) is a primary complication after phacoemulsification combined with intraocular lens (IOL) implantation, which attributed to adhesion, proliferation, and migration of residual epithelial cells on IOL. Although surface hydrophilic coating considered be powerful way inhibit PCO incidence surgery, it requires complex post-production processes, thus limiting their applicability. In comparison, bulk modification stable, effective, facile IOL synthesis method for prevention. Herein, new anti-adhesive material was designed successfully synthesized by radical copolymerization ethylene glycol phenyl ether methacrylate (EGPEMA) 2-(2-ethoxyethoxy) ethyl acrylate (EA). The physicochemical properties P(EGPEMA-co-EA) copolymer materials, including chemical structure, mechanical, thermal, surface, optical properties, were analyzed using 1H NMR spectroscopy, FT-IR tensile test, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), water contact angle measurement, UV–vis spectroscopy. elongation at break the modulus elasticity tunable through change composition monomers. Compared other components, results showed that materials (70% EGPEMA in mass ratio, F7) are suitable preparation foldable lower elastic higher break. TGA DSC has high thermal stability, glass transition temperature F7 16.1 °C. measurement introduction EA improved hydrophilicity material. percentage transmittance all copolymers 400–800 nm above 85%. Then, biocompatibility evaluated vitro assay subcutaneous implantation. Both implantation experiments exhibited good anti-adhesion effect no cytotoxicity. Finally, performed, vivo confirmed prevention ability as well materials.

Language: Английский

Architectural Design of Block Copolymers DOI Creative Commons
Zhanwen Xu, Qingshu Dong, Weihua Li

et al.

Macromolecules, Journal Year: 2024, Volume and Issue: 57(5), P. 1869 - 1884

Published: Feb. 19, 2024

Highly designable architectures of polymers endow the same polymer with different properties. In principle, diverse should enrich self-assembly behavior block copolymers, providing a possibility for formation many novel ordered phases. However, it is infeasible to simply search huge library desired new phases, and requires some valid guiding principles efficiently designing copolymers. past decade, sophisticated mechanisms have been proposed in addition common mechanism that copolymers dictated by competition between interaction energy stretching energy. To realize these constitutes design A series theoretical works demonstrated one or more can be derived thus properly designed achieve date, only flexible are considered. future, concept phases extended broader range e.g., semiflexible charged. addition, would useful properties not chain architecture but also phase-separated structure.

Language: Английский

Citations

19
Drug-free contact lens based on quaternized chitosan and tannic acid for bacterial keratitis therapy and corneal repair DOI

Zehui Jiao,

Qiuyi Huo,

Xuanyu Lin

et al.

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 286, P. 119314 - 119314

Published: March 4, 2022

Language: Английский

Citations

56
Thermoresponsive polymers with LCST transition: synthesis, characterization, and their impact on biomedical frontiers DOI Creative Commons
Yichun Yuan, Konpal Raheja, Nathalie B. Milbrandt

et al.

RSC Applied Polymers, Journal Year: 2023, Volume and Issue: 1(2), P. 158 - 189

Published: Jan. 1, 2023

Enhancing our comprehension of the structural influences alongside characterization tools for thermoresponsive polymers will pave way to design and deploy more advanced biomaterials, holding promise future applications in public health.

Language: Английский

Citations

32
Current trend on preparation, characterization and biomedical applications of natural polysaccharide-based nanomaterial reinforcement hydrogels: A review DOI

A.Z. Najihah,

Mohamad Zaki Hassan, Zarini Ismail

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132411 - 132411

Published: May 31, 2024

Language: Английский

Citations

15
Emerging polymeric biomaterials and manufacturing techniques in regenerative medicine DOI Creative Commons
Dan Xia,

Jiatian Chen,

Zhongyang Zhang

et al.

Aggregate, Journal Year: 2022, Volume and Issue: 3(5)

Published: Feb. 16, 2022

Abstract The current demand for patients’ organ and tissue repair regeneration is continually increasing, where autologous or allograft the golden standard treatment in clinic. However, due to shortage of donors, mismatched size modality, functional loss donor region, possible immune rejection, so forth, application auto‐/allo‐grafts frequently hindered many cases. In order solve these problems, artificial constructs structurally functionally imitating extracellular matrix have been developed as substitutes promoting cell attachment, proliferation, differentiation, ultimately forming tissues organs better regeneration. Particularly, polymeric materials widely utilized regenerative medicine because their ease manufacturing, flexibility, biocompatibility, well good mechanical, chemical, thermal properties. This review presents a comprehensive overview variety materials, fabrication methods applications medicine. Finally, we discussed future challenges perspectives development clinical transformation biomaterials.

Language: Английский

Citations

38
Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery DOI Creative Commons

Chenqi Luo,

Hanle Wang,

Xinyi Chen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: June 8, 2022

Advances in cataract surgery have increased the demand for intraocular lens (IOL) materials. At present, progress of IOL materials mainly contains further improving biocompatibility, providing better visual quality and adjustable ability, reducing surgical incision, as well dealing with complications such posterior capsular opacification (PCO) ophthalmitis. The purpose this review is to describe research relevant classified according different clinical purposes. innovation often based on common market, silicon acrylate. Special properties functions are obtained by adding extra polymers or surface modification. Most these studies not yet been commercialized, which requires a large number trials. But they provide valuable thoughts optimization function.

Language: Английский

Citations

30
Comprehensive Review of Hydrogel Synthesis, Characterization, and Emerging Applications DOI Open Access
A. Sathiya Priya,

R. Premanand,

Indhumathi Ragupathi

et al.

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(11), P. 457 - 457

Published: Nov. 4, 2024

Hydrogels play a crucial role due to their high-water content and 3D structure, which make them ideal for various applications in biomedicine, sensing, beyond. They can be prepared from variety of biomaterials, polymers, combinations, allowing versatility properties applications. include natural types derived collagen, gelatin, alginate, hyaluronic acid, as well synthetic based on polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide (PAAm). Each type possesses distinct properties, such mechanical strength, biodegradability, biocompatibility, tailored wound healing, contact lenses, bioprinting, tissue engineering. The hydrogels mimics environments, promoting cell growth nutrient waste exchange, supports the development functional tissues. serve scaffolds engineering applications, including cartilage bone regeneration, vascular engineering, organ-on-a-chip systems. Additionally, encapsulate deliver therapeutic agents, factors or drugs, specific target sites body. through three primary methods: physical crosslinking, relies non-covalent interactions entanglements hydrogen bonding; chemical forms covalent bonds between polymer chains create stable structure; irradiation-based where UV irradiation induces rapid hydrogel formation. choice crosslinking method depends desired hydrogel. By providing biomimetic environment, facilitate differentiation, support formation, aid regeneration damaged diseased tissues while delivering agents. This review focuses critical advancements processing routes development, summarizing characterization application hydrogels. It also details key healing challenges future perspectives field.

Language: Английский

Citations

7
Vinyl Polymers as Key Materials in Contact Lens Design: A Review of Progress and Future Directions DOI

Lina M. Shaker,

Ahmed A. Al‐Amiery, Wan Nor Roslam Wan Isahak

et al.

Starch - Stärke, Journal Year: 2024, Volume and Issue: 76(7-8)

Published: March 1, 2024

Abstract Vinyl polymers, crucial in contemporary contact lens design, present unique attributes with promising implications for vision correction. This comprehensive review navigates the trajectory and future trajectories of vinyl polymer‐based lenses. The introduction underscores vital role lenses correction positions polymers as ideal materials due to their exceptional properties. Delving into material specifics—high oxygen permeability, optical clarity, surface wettability, mechanical strength—the analysis emphasizes influence on corneal health, comfort, durability. versatility manufacturing techniques, encompassing spin casting, molding processes, polymerization, modification, feasibility crafting high‐quality Examining clinical applications, daily disposables, extended wear, silicone hydrogel, specialty lenses, alongside biocompatibility assessments user feedback, provides a nuanced understanding effectiveness. article candidly addresses challenges—dehydration, deposits, stability, durability—alongside regulatory considerations. Future prospects involve novel formulations, smart materials, bioinspired designs, noninvasive technologies amplify comfort performance. In conclusion, this distills progress, acknowledges challenges, charts sanguine course polymer advancing envisioning marked by enhanced technologies.

Language: Английский

Citations

6
Current Innovations in Intraocular Pressure Monitoring Biosensors for Diagnosis and Treatment of Glaucoma—Novel Strategies and Future Perspectives DOI Creative Commons

Rubiya Raveendran,

Lokesh Prabakaran, Rethinam Senthil

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 663 - 663

Published: June 18, 2023

Biosensors are devices that quantify biologically significant information required for diverse applications, such as disease diagnosis, food safety, drug discovery and detection of environmental pollutants. Recent advancements in microfluidics, nanotechnology electronics have led to the development novel implantable wearable biosensors expedient monitoring diseases diabetes, glaucoma cancer. Glaucoma is an ocular which ranks second leading cause loss vision. It characterized by increase intraocular pressure (IOP) human eyes, results irreversible blindness. Currently, reduction IOP only treatment used manage glaucoma. However, success rate medicines treat quite minimal due their curbed bioavailability reduced therapeutic efficacy. The drugs must pass through various barriers reach space, turn serves a major challenge treatment. Rapid progress has been observed nano-drug delivery systems early diagnosis prompt therapy diseases. This review gives deep insight into current field detecting treating glaucoma, well continuous IOP. Various nanotechnology-based achievements, nanoparticle/nanofiber-based contact lenses can efficiently monitor efficient also discussed.

Language: Английский

Citations

16
Preparation and Evaluation of Bacterial Nanocellulose/Hyaluronic Acid Composite Artificial Cornea for Application of Corneal Transplantation DOI

Yuhua Luo,

Geli Li,

Lin Chen

et al.

Biomacromolecules, Journal Year: 2022, Volume and Issue: 24(1), P. 201 - 212

Published: Nov. 28, 2022

The treatment for corneal damage requires donor transplantation, but there is a serious scarcity of corneas worldwide. In this study, we aimed to design new artificial cornea with good cytocompatibility, excellent optical properties and suture resistance, great moisturizing properties. A bacterial nanocellulose (BNC) membrane anisotropic mechanical high light transmission was produced in horizontal rotary drum reactor. However, as potential material keratoplasty, the transparency BNC were not satisfactory. Thus, hyaluronic acid (HA) introduced synthesize BNC/HA composite by using 1,4-butanediol diglycidyl ether (BDDE) chemical cross-linking agent. micro-morphology, transmittance, properties, water content, moisture retention ability, cytocompatibility membranes further evaluated. HA fixed network bond, found have transmittance (up 95.96%). showed instance, its tensile strength exceeded human normal intraocular pressure (IOP) (1.33-2.80 kPa), maximum burst about 130 kPa, 46-97 times that IOP, force close amniotic (0.1 N). Based on three-dimensional scaffold absorption characteristics HA, had content ability. rabbit stromal cells cultured vitro substitute cytocompatibility. BDDE most frequently used cross-linker products current cosmetic medicine industry owing long-term safety records over 15 years. Therefore, hydrogel cross-linked has keratoplasty or ocular surface repair.

Language: Английский

Citations

19