Alveolar
bone
defects
caused
by
oral
trauma,
alveolar
fenestration,
periodontal
disease,
and
congenital
malformations
can
severely
affect
function
facial
aesthetics.
Despite
the
successful
clinical
applications
of
grafts
or
substitutes,
optimal
regeneration
continues
to
be
challenging
due
complex
environment
its
unique
physiological
functions.
Hydrogels
that
serve
as
promising
candidates
for
tissue
are
under
development
meet
specific
needs
increased
capacity
improved
operational
efficiency
in
repair.
In
this
review,
we
emphasize
considerations
hydrogel
design
summarize
latest
hydrogels
prevalent
diseases
related
defects.
The
future
perspectives
challenges
application
field
also
discussed.
Deepening
our
understanding
these
biomaterials
will
facilitate
advent
novel
inventions
improve
outcome
regeneration.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(2), P. 819 - 828
Published: Jan. 22, 2024
The
combinational
properties
with
excellent
mechanical
properties,
adhesive
performance,
hemostatic
ability,
antibacterial
action,
and
wound
healing
efficacy
are
highly
desirable
for
injectable
hydrogels'
practical
applications
in
hemorrhage
control
closure,
but
designing
one
single
hydrogel
system
integrating
such
is
still
difficult.
Herein,
a
simplified
yet
straightforward
strategy
proposed
to
prepare
an
robust
poly(N,N-dimethylacrylamide)
(PDMAA)/carboxymethyl
chitosan
(CMCS)
induced
by
tranexamic
acid
(TXA).
TXA
not
only
promotes
the
rapid
generation
of
free
radicals
also
introduces
multiple
hydrogen
bonds
into
network.
Moreover,
as
common
clinical
drug,
itself
has
effects.
In
addition,
CMCS
imparts
sterilization
hemostasis
effects
hydrogel,
thereby
promoting
healing.
Besides,
amino
carboxyl
groups
on
molecules
hydroxyl,
amino,
can
form
wet
biological
tissues,
leading
good
tissue
adhesion
hydrogel.
As
result,
(up
1.83
MPa
at
90%
compression
strain),
performance
18.7
kPa
strength
porcine
skin
tissue),
biocompatibility,
activity,
be
fabricated
within
several
minutes.
These
advantages
enable
efficiently
stop
(blood
loss
amount:
110
mg;
time:
25
s)
promote
process
(wound
closure
rate
2
weeks:
83%),
which
verified
using
rat
models
liver
bleeding
infected
full
thickness
defect.
Overall,
this
facile
design
incorporating
unique
will
greatly
advance
hydrogel's
application
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(33)
Published: June 6, 2024
The
growing
aging
population,
with
its
associated
chronic
diseases,
underscores
the
urgency
for
effective
tissue
regeneration
strategies.
Biomaterials
play
a
pivotal
role
in
realm
of
reconstruction
and
regeneration,
distinct
shift
toward
minimally
invasive
(MI)
treatments.
This
transition,
fueled
by
engineered
biomaterials,
steers
away
from
surgical
procedures
to
embrace
approaches
offering
reduced
trauma,
accelerated
recovery,
cost-effectiveness.
In
MI
repair
cargo
delivery,
various
techniques
are
explored.
While
situ
polymerization
is
prominent,
it
not
without
challenges.
narrative
review
explores
diverse
fabrication
methods,
biofunctionalization
injectable
pre-formed
scaffolds,
focusing
on
their
unique
advantages.
exhibiting
compressibility,
controlled
injection,
maintained
mechanical
integrity,
emerge
as
promising
alternative
solutions
conclusion
this
emphasizes
importance
interdisciplinary
design
facilitated
synergizing
fields
materials
science,
advanced
3D
biomanufacturing,
mechanobiological
studies,
innovative
regeneration.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 11, 2024
Abstract
Coordinating
the
immune
response
and
bioenergy
metabolism
in
bone
defect
environments
is
essential
for
promoting
regeneration.
Mitochondria
are
important
organelles
that
control
internal
balance
metabolism.
Repairing
dysfunctional
mitochondria
has
been
proposed
as
a
therapeutic
approach
disease
intervention.
Here,
an
engineered
hierarchical
hydrogel
with
responsiveness
can
adapt
to
regeneration
environment
mediate
targeted
transfer
between
cells.
The
continuous
supply
of
by
macrophages
restore
mitochondrial
marrow
mesenchymal
stem
cells
(BMSC).
Fundamentally
solving
problem
insufficient
energy
support
BMSCs
caused
local
inflammation
during
repair
This
discovery
provides
new
strategy
repair,
which
research
value
practical
application
prospects
treatment
various
diseases
dysfunction.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(28), P. 30035 - 30070
Published: July 2, 2024
Hydroxyapatite
can
combine
with
polysaccharide
originating
biomaterials
special
applications
in
the
biomedical
field.
In
this
review,
synthesis
of
(nano)composites
is
discussed,
focusing
on
natural
polysaccharides
such
as
alginate,
chitosan,
and
pectin.
way,
advances
recent
years
development
preparing
materials
are
revised
discussed.
Therefore,
an
overview
polyssacharides@hydroxyapatites
presented.
Several
studies
based
chitosan@hydroxyapatite
combined
other
inorganic
matrices
highlighted,
while
pectin@hydroxyapatite
present
a
smaller
number
reports.
Biomedical
drug
carriers,
adsorbents,
bone
implants
combining
their
dependence
nature
interactions
molecular
scale
type
used,
which
relevant
aspect
to
be
explored.
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Rapid
gelation
hydrogels
have
garnered
significant
attention
due
to
their
simple
synthesis,
high
efficiency,
low
cost,
and
environmental
sustainability,
which
enable
meet
critical
demands
for
scalability
green
chemistry
unlocking
opportunities
across
diverse
application
fields.
This
review
synthesizes
current
advancements
in
the
mechanisms
driving
rapid
gelation,
encompassing
self-assembly
processes,
MXene-triggered
redox-driven
reactions,
coordination
chemistry,
Schiff
base
other
innovative
strategies.
The
discussion
extends
far-reaching
applications,
from
advanced
therapeutic
platforms
high-performance
energy
devices
precision
sensors
adaptive
soft
actuators.
By
critically
evaluating
recent
progress
addressing
existing
challenges,
this
not
only
deepens
understanding
of
mechanisms,
but
also
provides
scientific
insights
practical
guidance
foster
interdisciplinary
integration
drive
material
innovation
synthesis
technologies.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 21, 2025
Hydrogel
bioadhesive
is
widely
used
in
tissue
engineering,
flexible
electronics,
and
other
fields
because
of
its
mechanical
softness
good
biocompatibility.
However,
due
to
the
differences
strength
various
biological
tissues,
properties
specific
hydrogel
bioadhesives
are
difficult
easily
adjust
adapt
different
strengths.
Here,
we
propose
a
poly(methacrylamide-polyethylene
glycol-N-hydroxysuccinimide
ester-co-acrylic
acid)
PEGgel
(MAP)
based
on
drying
cross-linking
mechanism
polymer
platform
with
PEG
as
solvent.
Compared
reported
adhesives,
MAP
can
tensile
from
130
kPa
1
MPa
fracture
strain
149%
2653%
by
modifying
molecular
weight
proportion
solvent
PEG.
It
also
exhibits
robust
adhesion
tissues
substrates,
shear
pigskin
glass
reaching
6.8
MPa,
respectively.
The
application
for
tendon
healing
movement
monitoring
demonstrates
tough
compliant
between
hydrogel,
device,
tissues.
Combined
long-term
storage
capability,
3D-printable
ability,
self-healing
biocompatibility,
represents
promising
approach
development
bioadhesives.
