Colloid & Polymer Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 225, P. 120592 - 120592
Published: Jan. 25, 2025
Language: Английский
Citations
1
JCIS Open, Journal Year: 2024, Volume and Issue: 16, P. 100126 - 100126
Published: Nov. 12, 2024
Language: Английский
Citations
7
Precision medicine and engineering., Journal Year: 2024, Volume and Issue: 1(1), P. 100004 - 100004
Published: Aug. 13, 2024
The vesicle, which consists of the cytoplasm encapsulated by lipid bilayer, has acted as an important mediator intercellular communication a potential tool for disease treatment during past decade. In addition to ability biological amphiphiles form vesicles, artificial vesicles can also be formed from synthetic polymers, have been widely applied in transport, temporary storage and chemical reaction chambers. this review, we summarized progress use polymer nanoreactors biomedical applications. First, various preparation methods, including hydration, polymerization-induced self-assembly, solvent exchange, emulsion phase transfer, microfluidics flash nanoprecipitation, are compared here. Second, applications nanoreactors, such stimuli-responsive drug delivery, blood–brain barrier penetration, enhanced physiological stability, diseases, highlighted review. addition, existing obstacles future development directions proposed broader clinical translations.
Language: Английский
Citations
4
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
The present investigation aims to develop a reactive oxygen species (ROS) and esterase-responsive biodegradable mannosylated polyurethane effectively deliver the encapsulated antileishmanial drug amphotericin B (AmB) selectively infected macrophage cells. Owing suitable amphiphilic balance, as-synthesized glycosylated (
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Amphiphilic polymers with distinct polarity differences, known as sharp contrast (SPCPs), have gained much attention for their ability to form micelles low critical micelle concentrations (CMCs) and potential in anticancer drug delivery. This study addresses the limited research on structure–property relationships of SPCPs by developing various exploring physicochemical properties biological applications. Specifically, superhydrophobic aliphatic palmitoyl (Pal) was coupled superhydrophilic zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) Pal-pMPC diblock copolymers. Adjusting lengths hydrophilic chains allowed creation structures varying hydrophilic–hydrophobic ratios formation. Comprehensive evaluations were carried out, including particle size, CMC, chain exchange rates, cellular uptake efficiency, effectiveness. Our findings indicate that optimal significantly enhanced cytotoxicity both two-dimensional (2D) three-dimensional (3D) tumor models, offering valuable insights designing
Language: Английский
Citations
0
Soft Matter, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Periodically grafted amphiphilic polymers (PGAPs) belong to an interesting class of that carry long hydrophobic alkylene segments along the backbone and periodically located hydrophilic pendant segments, such as polyethylene glycol monomethyl ether (MPEG). In earlier studies, we showed PGAPs undergo zigzag folding segregate MPEG segments; consequently, they organize in solid state yield a lamellar morphology with precisely tunable domain sizes. present study, two new clickable polyesters were prepared; one bearing dodecyl (C12) between adjacent propargyl units other carrying longer eicosyl (C20) segments. These clicked MPEG-azides different molecular weights, namely 550, 750 2000, generate series varying hydrophilic-lyophilic balance (hlb) and, propensities. The collapse these PGAP chains solution was examined by pulse field gradient nuclear magnetic resonance (PFG NMR) diffusometry chloroform-methanol mixtures composition; diffusion constants, estimated from measurements, underwent sudden increase at specific methanol content, which signified chain-collapse transition. As expected, occurred lower content smaller Additionally, variation relative intensities proton peaks belonging central segment, upon becomes more solid-like, also exhibited drop roughly same solvent composition, reconfirming occurs structure dense core solvated shell.
Language: Английский
Citations
0
Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 319 - 354
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Combining an amphiphilic block copolymer polybutadiene-b-poly(ethylene glycol) (PBD-b-PEO), ionizable lipid, a helper and cholesterol produces thermostable BNPs. Luciferase mRNA-BNPs can be stored for over 1 year at 4 °C with no evidence of degradation to the mRNA or nanocarrier. In vivo, exhibit greater affinity secondary lymphoid organs than mRNA-lipid nanoparticles (LNPs) are efficiently taken up by macrophages dendritic cells. Freshly fabricated ovalbumin (OVA) elicit robust OVA-specific IgG functional memory CD8+ T cells that persist least 5 months. Immunogenicity remains intact after 24 weeks storage °C. Anti-PEG antibodies not boosted repeated administration mRNA-BNPs, unlike mRNA-LNPs. Syrian hamsters vaccinated SARS-CoV-2 spike protected against weight loss associated infection potently suppress pulmonary viral loads. Protective efficacy is comparable conferred Comirnaty biosimilar. Cumulatively, thermostable, immunogenic possess potential clinical application.
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1030 - 1030
Published: April 10, 2025
Amphiphilic block copolymers with complex topologies (e.g., star and brush topologies) have attracted significant attention in drug delivery owing to their superior performance over linear micelles. However, precise synthesis structure–property relationships require further investigation. In this study, hydroxylated polybutadiene adjustable topology hydroxyl group density was employed as a macroinitiator synthesize well-defined amphiphilic poly (ethylene oxide)-b-poly(ε-caprolactone-ran-δ-valerolactone) (PEO-b-P(CL-ran-VL)) via ring-opening polymerization (ROP). A series of linear, star, linear–comb, star–comb were prepared curcumin-loaded micellar carriers for the study. The self-assembly behavior, encapsulation efficiency, vitro release profiles these aqueous environments systematically investigated. results demonstrated that increasing branch length effectively reduced micelle size from 143 96 nm enhanced efficiency 27.3% 39.8%. Notably, architecture exhibited 1.2-fold higher curcumin than counterparts. Furthermore, optimized nanoparticles displayed sustained kinetics (73.38% 15 days), outperforming conventional This study establishes quantitative relationship between copolymer performance, providing molecular design platform programmable nanocarriers tailored diverse therapeutic requirements various diseases.
Language: Английский
Citations
0