Colloid & Polymer Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 20, P. 1 - 24
Published: Dec. 31, 2024
Abstract: Amphiphilic copolymers are composed of both hydrophilic and hydrophobic chains, which can self-assemble into polymeric micelles in aqueous solution via the hydrophilic/hydrophobic interactions. Due to their unique properties, have been widely used as drug carriers. Poorly soluble drugs be covalently attached polymer chains or non-covalently incorporated micelles, with improved pharmacokinetic profiles enhanced efficacy. In recent years, stimuli-responsive amphiphilic copolymer attracted significant attention. These respond specific stimuli, including physical triggers (light, temperature, etc). chemical stimuli (pH, redox, physiological factors (enzymes, ATP, Under these structures properties change, enabling targeted therapy controlled release tumors. strategies offer new avenues approaches enhance tumor efficacy reduce side effects. We will review applications different types therapy, aiming provide valuable guidance for future research directions clinical translation. Keywords: stimuli-responsive, delivery system
Language: Английский
Citations
2
Journal of Thermoplastic Composite Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 9, 2024
Biomimetic nanoparticles (BioM NPs) are an innovative strategy for nanomedicine (NanoMed) that combines the advantages of artificial materials with biological functioning natural systems. Ongoing research attempts to enhance their design, and stability, solve problems broader applications in medicine biotechnology. NanoMed ideas intensively researched preclinical because they provide unique disease management. It has developed novel therapeutic strategies combating viral infections increasing treatment success rates. The creation nanocarriers drug delivery systems is critical evolution NanoMed, but there still much learn about this quickly evolving field. To contribute existing knowledge cover gaps, our present review article will discuss state-of-the-art BioM NPs three sections. First, methods NP production synergistic interactions human cells, tissues, organs, organ be discussed. Followed by a discussion several NanoMeds (wound healing, targeted delivery, theranostics, cancer therapy, bone formation and/or regeneration), concluding application NPs, challenges associated these applications, prospects.
Language: Английский
Citations
1
Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 11, 2024
(Meth)acrylic polymers are massively produced due to their inherently attractive properties. However, the vast majority of these derived from fossil resources, which is not aligned with tendency reduce gas emissions. In this context, (meth)acrylic biomass (biobased polymers) gaining momentum, as application in different areas can only stand comparison but even surpass, some cases, performance petroleum-derived ones. review, we highlight design and synthesis lactate esters (LEs) amides (LAs), both lactic acid. While biobased have been widely studied reviewed, poly(meth)acrylates pendant LE LA moieties evolved slowly until recently when significant achievements made. Hence, constraints opportunities arising previous research area presented, focusing on well-defined for preparation advanced materials.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137305 - 137305
Published: Nov. 7, 2024
Language: Английский
Citations
1
Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(9), P. 1429 - 1440
Published: Aug. 19, 2024
Drug delivery to the esophagus through systemic administration remains challenging, as minimal drug reaches desired target. Local offers potential for improved efficacy while minimizing off-target toxicities but necessitates bioadhesive properties mucosal delivery. Herein, we describe synthesis of two new mucoadhesive amphiphilic copolymers prepared by sequential ring-opening copolymerization or postpolymerization click conjugation. Both strategies yield block containing a hydrophilic amine-functionalized poly-amido-saccharide and either hydrophobic alkyl derivatized poly(lactic acid), respectively. The latter resulting readily self-assemble into spherical, ≈200 nm diameter, positively charged nanoparticles. NPs entrap ultrahigh levels paclitaxel via encapsulation free conjugated biodegradable, biocompatible poly(1,2-glycerol carbonate). Paclitaxel-loaded rapidly enter cells, release paclitaxel, are cytotoxic esophageal OE33 OE19 tumor cells in vitro, and, importantly, demonstrate mucoadhesion compared conventional poly(ethylene glycol)-poly(lactic acid) nanoparticles ex vivo tissue.
Language: Английский
Citations
0
Polymer Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
The noncovalent protection of Et 3 B avoids the complex and deprotection steps directly synthesizes PLA- b -PAA block copolymers.
Language: Английский
Citations
0
Colloid & Polymer Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Citations
0