Alkaline Phosphatase-Instructed Peptide Assemblies for Imaging and Therapeutic Applications DOI
Chengfan Wu,

Pingge Jiang,

Wen Su

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5609 - 5629

Published: Aug. 26, 2024

Self-assembly, a powerful strategy for constructing highly stable and well-ordered supramolecular structures, widely exists in nature living systems. Peptides are frequently used as building blocks the self-assembly process due to their advantageous characteristics, such ease of synthesis, tunable mechanical stability, good biosafety, biodegradability. Among initiators peptide self-assembly, enzymes excellent candidates guiding this under mild reaction conditions. As crucial commonly biomarker, alkaline phosphatase (ALP) cleaves phosphate groups, triggering hydrophilicity-to-hydrophobicity transformation that induces self-assembly. In recent years, ALP-instructed has made breakthroughs biological imaging therapy, inspiring development biomaterials diagnosis therapeutics. review, we highlight most advancements assemblies provide perspectives on potential impact. Finally, briefly discuss ongoing challenges future research field.

Language: Английский

Context dependence in assembly code for supramolecular peptide materials and systems DOI
Kübra Kaygisiz, Deborah Sementa, Vignesh Athiyarath

et al.

Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

Citations

0
Substituent group induced fluorescence emission transformation and supramolecular chirality inversion in glutamide based amphiphile assemblies DOI
Lukang Ji,

Ziwei Guo,

Xuan Dong

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140258 - 140258

Published: Oct. 9, 2024

Language: Английский

Citations

0
Hydrogen Bond, Protonation, and Coordination-Induced Supramolecular Chirality Inversion in Glutamide-Based Amphiphilic Self-assembly DOI
Lukang Ji,

Ziwei Guo,

Menghua Du

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140585 - 140585

Published: Nov. 7, 2024

Language: Английский

Citations

0
Alkaline Phosphatase-Instructed Peptide Assemblies for Imaging and Therapeutic Applications DOI
Chengfan Wu,

Pingge Jiang,

Wen Su

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5609 - 5629

Published: Aug. 26, 2024

Self-assembly, a powerful strategy for constructing highly stable and well-ordered supramolecular structures, widely exists in nature living systems. Peptides are frequently used as building blocks the self-assembly process due to their advantageous characteristics, such ease of synthesis, tunable mechanical stability, good biosafety, biodegradability. Among initiators peptide self-assembly, enzymes excellent candidates guiding this under mild reaction conditions. As crucial commonly biomarker, alkaline phosphatase (ALP) cleaves phosphate groups, triggering hydrophilicity-to-hydrophobicity transformation that induces self-assembly. In recent years, ALP-instructed has made breakthroughs biological imaging therapy, inspiring development biomaterials diagnosis therapeutics. review, we highlight most advancements assemblies provide perspectives on potential impact. Finally, briefly discuss ongoing challenges future research field.

Language: Английский

Citations

0