Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 29, 2025

The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence lower limb amputation. A pivotal factor in impediment is reduced production endogenous nitric oxide (NO) due hyperglycemic microenvironment typical diabetes. While both and exogenous NO have been shown promote process wounds, direct application wound management limited its gaseous nature risk explosive release. This review summarizes recent advances nanodressings incorporating donors treatment detailing specific conditions under which these facilitate release, a focus on beneficial effects NO, strategies for supplementation, encountered clinical translation as clinically viable nanomedicine context improving healing.

Language: Английский

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Recent advancement in the anticancer efficacy of the natural flavonoid scutellarin: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Scutellarin (SC), a natural flavonoid, has been expansively employed in treating innumerable inflammation-related diseases due to its antitumor, antiinflammatory, anticancer, and antioxidant potential. can inhibit significant inflammatory cell signaling pathways, comprisingPI3K/Akt, NF-κB, MAPK, while activating antioxidant-related pathways such as Nrf2 ARE. Numerous reviews have outlined scutellarin’s pharmacological effects associated mechanisms diseases. Several studies elucidated the of anticancer activity by inhibiting various pathways; however, our knowledge, none distinguished potential scutellarin based on different human cancer types. Our review detailed insights about type body. Furthermore, we also formulations, combinatorial therapies, comprehensive mechanistic research deliver enhanced effective treatment options for patients. This study will provide thorough into scutellarin, supporting development promising candidate treatment.

Language: Английский

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Visible Light‐Triggered Precision SO₂ Release from Polymeric Nanomedicine for Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract A number of polymeric sulfur dioxide (SO 2 )‐releasing nanomedicines have demonstrated promise in cancer treatment by enabling controlled SO release, triggered endogenous (redox) stimuli. However, the heterogeneous distribution these stimuli across different organs presents a significant challenge to clinical translation. To overcome this limitation, developing donors that respond exogenous triggers offers promising strategy for therapeutic advancement. Herein, an stimuli‐responsive is presented generating from series amphiphilic block copolymers ( BCPx ) under visible light irradiation (427 nm) biological environment, aiming evaluate their potential therapy. The coumarin‐based, water‐soluble polymers form well‐defined nanostructures BCPxNs aqueous media, releasing 70–85% theoretical within 4 h. Moreover, exhibit self‐reporting behavior upon release. In vitro cellular assays with BCP2Ns demonstrate enhanced antiproliferative effect cervical carcinoma HeLa cells nm), IC 50 value 0.3 mg mL −1 . Investigations using confocal microscopy and flow cytometry confirm ‐induced cell death. Overall, underscores light‐responsive spatiotemporal control

Language: Английский

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Nitric oxide-delivering surface modification for tailoring cell-material interactions on medical device surface: From surface-functionalized design to therapeutic applications

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162378 - 162378

Published: April 1, 2025

Language: Английский

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Structurally Engineered SO₂–Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Cationic antimicrobial agents are widely recognized for combating microbial infections through their membrane-disruptive properties. Recently, sulfur dioxide (SO2) gas therapy has emerged as a promising alternative treating diseases, including bacterial infections. However, current systems often target only specific strains. Herein, we present amphiphilic alternating copolymers, DAPx (x = 1, 2, 3), incorporating cationic residues and thiol-responsive SO2-releasing moieties. In aqueous environments, copolymers self-assemble into micellar nanoassemblies (DAPxNp), exposing hydrophilic outward encapsulating hydrophobic moieties within the core to enable controlled sustained release of SO2 in presence glutathione (GSH). vitro studies reveal excellent biocompatibility DAP2 Np with broad-spectrum antibacterial activity against both Gram-positive (Bacillus subtilis, Staphylococcus aureus) Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Mechanistic investigations confirm eradication via membrane disruption reactive oxygen species generation. This study underscores remarkable efficacy polymers resisting

Language: Английский

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Experimental and calculation study of co-delivery of insulin and nitric oxide carriers for diabetes and cardiovascular diseases

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 104, P. 106525 - 106525

Published: Dec. 15, 2024

Language: Английский

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