Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 46, P. 102704 - 102704
Published: April 15, 2025
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101462 - 101462
Published: Jan. 5, 2025
Fluorine magnetic resonance imaging (19F MRI) using polymer tracers overcomes limitations of conventional proton MRI by offering enhanced specificity. However, the lack systematic comparisons among fluorinated polymers has hindered rational tracer design. In this study, we synthesized an extensive library water-soluble copolymers varying ratios hydrophilic and monomers evaluated their 19F properties to identify key structure-property relationships. Optimizing hydrophilicity non-fluorinated comonomer increased fluorine content without compromising water solubility, thereby enhancing signal. Factors such as chemical structure, molecular interactions, relaxation times also significantly influenced performance. The optimized copolymer, poly((N-(2,2,2-trifluoroethyl)acrylamide)60-stat-(N-(2-hydroxyethyl)acrylamide)40), exhibited unprecedented sensitivity with detection limits below 1 mg mL-1, highest reported date. We demonstrated tracer's potential through successful in vivo visualization solid tumors mouse models, highlighting its promise for advanced biomedical applications.
Language: Английский
Citations
0
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)
Published: Feb. 1, 2025
ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels biomedical settings, especially the creation smart hydrogels. Traditional single‐network often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve strength via topological entanglements physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness stimuli, endowing with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, color‐changing properties. The purpose this article is elucidate factors that trigger stimuli IPN their impacts on cellular behavior, various applications they can serve. A comprehensive overview provided regarding classification, mechanisms, performance attributes, related subjects. Ultimately, review emphasizes promise hold fulfilling increasing need for innovative improved features sector.
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 11, 2025
Inspired by the responsiveness of natural systems to their surrounding environments, researchers have sought understand these biological processes and develop functional stimuli-responsive polymeric for a wide range applications such as drug delivery, imaging, regenerative medicine. Both synthetic polymers biopolymers been studied incorporated into assemblies different morphologies well hydrogels with diverse shapes dimensions. This special issue highlights recent research advances in this area, exciting challenges be tackled upcoming years.
Language: Английский
Citations
0
Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128175 - 128175
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380
Published: Feb. 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: 19(9), P. 9061 - 9069
Published: March 1, 2025
Owing to its negligible biological background and high magnetic resonance sensitivity, 19F imaging (MRI) has emerged as a competitive complement for 1H MRI, which is already widely used in biomedical research clinical practice. The performance of MRI greatly reliant on probes, the development poses considerable demands sources. Fluorinated ionic liquids (FILs) have recently attracted increasing attention alternative sources because their good aqueous solubility, ease chemical modification, fluorine contents. However, FIL-based probes significantly restricted by unfavorable relaxation times. Herein, we developed strategy modulate times (including both T1 T2) FILs exploiting paramagnetic enhancement effect Mn2+ ions promote capacity. three including EMIMBF4, BMIMOTf, BMIMPF6 are appropriately tuned with at optimized concentrations, resulting significant signal over 5-fold. We further utilized liposils encapsulate these construct enables fast clear illustrated series vivo experiments. Moreover, made probe containing all concentration, whose capacity multiplexed also validated Our study demonstrates promising potential "hot spot" more importantly, feasibility modulation construction high-performance probes.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Polymeric fluorinated nanoparticles (PFNPs) are useful materials in many applications, especially the field of 19F magnetic resonance imaging (MRI). Despite development numerous PFNPs with diverse chemical compositions and structures, those high fluorine content capable highly sensitive MRI remain scarce. Here we report an elegantly designed aqueous photo-polymerization-induced self-assembly (photo-PISA) system for synthesis effective applications. This innovative photo-PISA is enabled by two analogous monomers, allowing efficient production different morphologies (25 wt %) solution. These exhibit favorable properties morphology-dependent biological behavior, have potential as advanced polymeric nanomaterials drug delivery
Language: Английский
Citations
0
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 46, P. 102704 - 102704
Published: April 15, 2025
Language: Английский
Citations
0