Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound process. In this study, novel hydrogels (G-GLP) were using oxidized Ganoderma lucidum (OGLPs) carboxymethyl chitosan via Schiff base reaction, which did not require addition of any chemical cross-linking agent. The showed excellent mechanical properties biocompatibility. Moreover, superior hemostatic performance mouse liver trauma tail amputation models. Importantly, G-GLP improved inflammation by promoting polarization macrophage M2 subtype, inhibiting M1 subtype reducing intracellular levels reactive oxygen species. vivo experiments demonstrated that accelerated total defect model blood vessel repair collagen deposition. These results demonstrate has as an effective dressing.

Language: Английский

A remotely triggered phase change hydrogel dressing for controlled release and promoting healing of infected wounds

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161828 - 161828

Published: March 1, 2025

Language: Английский

Catechol-grafted chitosan-based antioxidant hydrogel with rapid self-healing property for wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138509 - 138509

Published: Dec. 1, 2024

Language: Английский