Current Paradigms and Future Challenges in Harnessing Nanocellulose for Advanced Applications in Tissue Engineering: A Critical State-of-the-Art Review for Biomedicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1449 - 1449

Published: Feb. 9, 2025

Nanocellulose-based biomaterials are at the forefront of biomedicine, presenting innovative solutions to longstanding challenges in tissue engineering and wound repair. These advanced materials demonstrate enhanced mechanical properties improved biocompatibility while allowing for precise tuning drug release profiles. Recent progress design, fabrication, characterization these underscores their transformative potential biomedicine. Researchers employing strategic methodologies investigate characterize structure functionality nanocellulose In engineering, nanocellulose-based scaffolds offer opportunities replicate complexities native tissues, facilitating study effects on metabolism, vascularization, cellular behavior engineered liver, adipose, tumor models. Concurrently, has gained recognition as an dressing material, leveraging its ability deliver therapeutic agents via topical, transdermal, systemic pathways simultaneously promoting proliferation regeneration. The inherent transparency provides a unique advantage, enabling real-time monitoring healing progress. Despite advancements, significant remain large-scale production, reproducibility, commercial viability biomaterials. This review not only hurdles but also outlines directions future research, including need bioengineering dressings with scalable production incorporation novel functionalities clinical translation. By addressing key challenges, redefine biomedical material design unmet needs beyond.

Language: Английский

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and integration of grafted cells. Biomaterials have emerged as an attractive solution to this problem providing a protective microenvironment deliver cells injured tissues. The design biomaterials compatible with tissues promote tissue repair functional recovery focus neural engineering. A wealth research has explored different materials architectures combination bioactive cues glial cell growth maturation. After brief presentation biomaterial strategies sources, we review vivo evidences about efficacy stem cotransplantation (i) enhancing trophic effects, (ii) increasing integration, (iii) achieving preclinical models stroke, traumatic brain injury, Parkinson's disease, spinal cord injury. Furthermore, comprehensive perspective was offered regarding specific implementation tactics, obstacles, development orientations employing critical support transplantation.

Language: Английский