Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery DOI

Razhan Salah Othman,

Sara Zarei,

Hasan Rezaei Haghighat

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: April 1, 2025

ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.

Language: Английский

Oral Delivery Strategies for Biological Drugs DOI Open Access
Huiling Zeng, Mingyang Ma,

Xiuju Peng

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Biologics have low toxicity and are highly specific biocompatible, offering advantages over small-molecule drugs. The administration of biologics in oral form provides a significant benefit improving patient compliance. However, faces the challenge harsh gastrointestinal environment, including pH, enzyme degradation, poor intestinal epithelium permeability, which limits bioavailability biologics. As result, remains primarily parenteral form. This review introduces physiological barriers encountered by delivery, describes currently on market or under clinical trials, as well biologics-based technologies, discusses recent progress novel delivery technologies such nanoparticle-delivery systems, ionic liquids, microneedles. Specifically, colon-targeted approaches for also explored, colon could be more optimal absorption site due to having less diverse proteolytic enzymes relatively limited digestibility compared upper tract (GIT). Lastly, future research directions highlighted it is concluded that with an in-depth study biological drugs advancement methods, can pioneer new opportunities.

Language: Английский

Citations

0
Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery DOI

Razhan Salah Othman,

Sara Zarei,

Hasan Rezaei Haghighat

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: April 1, 2025

ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.

Language: Английский

Citations

0