Chitosan-Based Thermal-Coagulation Hydrogel System Driven by Multiple Interactions: Oxidation-Induced Fast Gelation and Enhanced Performance DOI
Yifan Liu, Guoyin Chen, Tianyu Zhou

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

The application of the chitosan/β-glycerophosphate (CS/β-GP) system is limited due to its weak mechanical performance, high concentration β-GP, and slow gelation. To revitalize this thermal-coagulation system, we used catechol-chitosan (CS-C) systematically investigated influence modification. By controlling grafting rate, it was found that solution pH pKa CS-C were both affected by decrease amino groups, whereas gelation time required β-GP content for gelling significantly decreased. Using oxidative properties catechol CS-C/β-GP hydrogel showed a 10-fold increment in stiffness, rapid (1-2 min), much lower (2-6 wt %). In addition, performed well antimicrobial biocompatibility tests. This first work elucidate mechanism modified chitosan systems, making chitosan-based systems field biomedicine tissue repair possible.

Language: Английский

Chitosan-Based Thermal-Coagulation Hydrogel System Driven by Multiple Interactions: Oxidation-Induced Fast Gelation and Enhanced Performance DOI
Yifan Liu, Guoyin Chen, Tianyu Zhou

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

The application of the chitosan/β-glycerophosphate (CS/β-GP) system is limited due to its weak mechanical performance, high concentration β-GP, and slow gelation. To revitalize this thermal-coagulation system, we used catechol-chitosan (CS-C) systematically investigated influence modification. By controlling grafting rate, it was found that solution pH pKa CS-C were both affected by decrease amino groups, whereas gelation time required β-GP content for gelling significantly decreased. Using oxidative properties catechol CS-C/β-GP hydrogel showed a 10-fold increment in stiffness, rapid (1-2 min), much lower (2-6 wt %). In addition, performed well antimicrobial biocompatibility tests. This first work elucidate mechanism modified chitosan systems, making chitosan-based systems field biomedicine tissue repair possible.

Language: Английский

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