Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media DOI
Hannah Dewey,

Jaron Jones,

Sydney Lucas

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(17), P. 15530 - 15539

Published: Aug. 29, 2023

Quaternary ammonium compounds (QACs) are widely used in disinfectants, cleaners, preservatives, cosmetics, and agriculture. Recently, QACs have been detected the human bloodstream, breast milk, neonatal mouse brain, which shows that these can cross biological barriers. In vivo studies showed chronic low-level exposure to causes developmental, reproductive, immune dysfunctions, whereas vitro indicate affect reproductive systems, disrupt cholesterol biosynthesis, increase inflammatory cytokines, decrease mitochondrial functions. Effects of on health gradually emerging, amid increased use QAC disinfectants during COVID-19 pandemic. Analysis fluids including blood, urine, sweat, saliva provide vital information determining effects analytes. Biofluid analysis is convenient yet crucial because non-invasive/or minimally invasive procedures be performed outside hospital settings. Interest optical detection methods for biofluid has growing due recent advances technologies availability tunable materials aid technologies. Detection near-infrared (NIR) spectral range advantageous over visible mainly minimal autofluorescence, light-scattering, absorption from native molecules NIR range. Photoluminescent single-walled carbon nanotubes (SWCNTs) promising candidates development probes sensors their non-photobleaching fluorescence, surface chemistry, high sensitivity. Herein, we report protein-rich media a model biofluid. We functionalized photoluminescent SWCNTs with bile salt derivatives enabled artificial sweat serum-protein-enriched media. The was significant at nanomolar concentrations, within threshold various physiological processes. Thus, nanotube-based could well suited fluids.

Language: Английский

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern DOI Creative Commons
William A. Arnold, Arlene Blum,

Jennifer Branyan

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(20), P. 7645 - 7665

Published: May 9, 2023

Quaternary ammonium compounds (QACs), a large class of chemicals that includes high production volume substances, have been used for decades as antimicrobials, preservatives, and antistatic agents other functions in cleaning, disinfecting, personal care products, durable consumer goods. QAC use has accelerated response to the COVID-19 pandemic banning 19 antimicrobials from several products by US Food Drug Administration 2016. Studies conducted before after onset indicate increased human exposure QACs. Environmental releases these also increased. Emerging information on adverse environmental health impacts QACs is motivating reconsideration risks benefits across life cycle their production, use, disposal. This work presents critical review literature scientific perspective developed multidisciplinary, multi-institutional team authors academia, governmental, nonprofit organizations. The evaluates currently available ecological profile identifies multiple areas potential concern. Adverse effects include acute chronic toxicity susceptible aquatic organisms, with concentrations some approaching levels Suspected or known outcomes dermal respiratory effects, developmental reproductive toxicity, disruption metabolic function such lipid homeostasis, impairment mitochondrial function. QACs' role antimicrobial resistance demonstrated. In regulatory system, how managed depends it used, example pesticides products. can result same receiving different degrees scrutiny depending agency regulating it. Further, Protection Agency's current method grouping based structure, first proposed 1988, insufficient address wide range chemistries, toxicities, scenarios. Consequently, exposures common mixtures sources remain largely unassessed. Some restrictions implemented elsewhere, primarily focused Assessing posed hampered vast structural diversity lack quantitative data majority compounds. important gaps provides research policy recommendations preserving utility chemistries while seeking limit effects.

Language: Английский

Citations

147
Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review DOI Creative Commons

Uttpal Anand,

Bashir Adelodun, Carlo Cabreros

et al.

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 20(6), P. 3883 - 3904

Published: Aug. 17, 2022

Abstract Almost all aspects of society from food security to disease control and prevention have benefited pharmaceutical personal care products, yet these products are a major source contamination that ends up in wastewater ecosystems. This issue has been sharply accentuated during the coronavirus pandemic 2019 (COVID-19) due higher use disinfectants other products. Here we review with focus on their occurrence environment, detection, risk, removal.

Language: Английский

Citations

109
Quaternary ammonium disinfectants and antiseptics: tolerance, resistance and potential impact on antibiotic resistance DOI Creative Commons
John M. Boyce

Antimicrobial Resistance and Infection Control, Journal Year: 2023, Volume and Issue: 12(1)

Published: April 13, 2023

Due to the substantial increase in use of disinfectants containing quaternary ammonion compounds (QACs) healthcare and community settings during COVID-19 pandemic, there is increased concern that heavy might cause bacteria develop resistance QACs or contribute antibiotic resistance. The purpose this review briefly discuss mechanisms QAC tolerance resistance, laboratory-based evidence their occurrence other real-world settings, possible impact on

Language: Английский

Citations

86
Ultraviolet C irradiation: A promising approach for the disinfection of public spaces? DOI Creative Commons
Ana Rita Pereira, Daniel F.O. Braga, Mariana Vassal

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 879, P. 163007 - 163007

Published: March 23, 2023

Ultraviolet irradiation C (UVC) has emerged as an effective strategy for microbial control in indoor public spaces. UVC is commonly applied air, surface, and water disinfection. Unlike common 254 nm UVC, far-UVC at 222 considered non-harmful to human health, being safe occupied spaces, still disinfection purposes. Therefore, allied the urgency mitigate current pandemic of SARS-CoV-2, increase UVC-based technology devices appeared market with levels pathogens reduction higher than 99.9 %. This environmentally friendly potential overcome many limitations traditional chemical-based approaches. The novel were thought be used spaces such hospitals, schools, transport minimize risk contamination propagation, saving costs by reducing manual cleaning equipment maintenance provided manpower. However, a lack information about parameters protocols disinfection, controversies regarding health environmental risks exist. In this review, fundamentals on are presented. Furthermore, deep analysis technologies available addressed, well their advantages limitations. comprehensive provides valuable inputs strategies development effective, reliable, systems.

Language: Английский

Citations

36
Low concentration quaternary ammonium compounds promoted antibiotic resistance gene transfer via plasmid conjugation DOI Open Access

Congcong Liu,

Shin Giek Goh,

Luhua You

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 887, P. 163781 - 163781

Published: May 4, 2023

Language: Английский

Citations

36
Hierarchical Superstructure of Plant Polyphenol and Arginine Surfactant for Long‐Lasting and Target‐Selective Antimicrobial Application DOI

Yutan Shen,

Hongrui Lin, Ming Yang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(19)

Published: Feb. 22, 2023

Antimicrobial agents are massively used to disinfect the pathogen contaminated surfaces since Corona Virus Disease 2019 (COVID-19) outbreak. However, their defects of poor durability, strong irritation, and high environmental accumulation exposed. Herein, a convenient strategy is developed fabricate long-lasting target-selective antimicrobial agent with special hierarchical structure through bottom-up assembly natural gallic acid arginine surfactant. The starts from rodlike micelles, further stacking into hexagonal columns finally interpenetrating spherical assemblies, which avoid explosive release units. assemblies show anti-water washing adhesion on various surfaces; thus, possess highly efficient broad-spectrum activities even after using up eleven cycles. Both in vitro vivo experiments prove that selective killing pathogens without generating toxicity. excellent virtues well satisfy increasing anti-infection demands exhibits great potential as clinical candidate.

Language: Английский

Citations

23
Antimicrobial Activity of Hydrogen Peroxide for Application in Food Safety and COVID-19 Mitigation: An Updated Review DOI Creative Commons
Asem Mahmoud Abdelshafy, Hudaa Neetoo, Fahad Al‐Asmari

et al.

Journal of Food Protection, Journal Year: 2024, Volume and Issue: 87(7), P. 100306 - 100306

Published: May 23, 2024

Hydrogen peroxide (H

Language: Английский

Citations

14
Cleaning products: Their chemistry, effects on indoor air quality, and implications for human health DOI Creative Commons

Heidi Salonen,

Tunga Salthammer, Emmanuelle Castagnoli

et al.

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108836 - 108836

Published: June 18, 2024

The use of cleaning and disinfecting products both at work home increased during the COVID-19 pandemic. Those often include surfactants, acids/bases, carcinogens such as chloroform, endocrine-disrupting chemicals, cyclosiloxanes, phthalates, synthetic fragrances, which may cause harmful health effects among professional cleaners well people exposed or in their workplaces. aim this study was to synthesize commonly used chemical, surface on indoor air quality, focusing chemical particulate matter pollutants, exposure, human residential public buildings. We also provide a summary recommendations avoid exposure suggest future research directions. PubMed, Google Scholar, Scopus, Web Science (WoS) were search literature. Analysis literature revealed that disinfectants increase occupants' variety contaminants matter. Occupational disinfectant has been linked an risk asthma rhinitis. Residential shown have adverse effect respiratory health, particularly onset, occurrence asthma(-like) symptoms children adults. Efforts reduce chemicals will require lowering content hazardous substances improving ventilation after cleaning. Experimentally examined, best practices careful selection can minimize burden pollutant indoors. In addition, indirect ways increasing people's awareness harmfulness safe practices, clear labelling products.

Language: Английский

Citations

13
From Personal Care to Coastal Concerns: Investigating Polyethylene Glycol Impact on Mussel’s Antioxidant, Physiological, and Cellular Responses DOI Creative Commons
Cristiana Roberta Multisanti, Giorgia Zicarelli,

Alessia Caferro

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 734 - 734

Published: June 17, 2024

Pharmaceutical and personal care products (PPCPs) containing persistent potentially hazardous substances have garnered attention for their ubiquitous presence in natural environments. This study investigated the impact of polyethylene glycol (PEG), a common PPCP component, on Mytilus galloprovincialis. Mussels were subjected to two PEG concentrations (E1: 0.1 mg/L E2: 10 mg/L) over 14 days. Oxidative stress markers both gills digestive glands evaluated; cytotoxicity assays performed haemolymph gland cells. Additionally, cell volume regulation (RVD assay) was assess physiological PEG-induced alterations. In gills, reduced superoxide dismutase (SOD) activity increased lipid peroxidation (LPO) at E1. gland, only LPO influenced, while SOD oxidatively modified proteins (OMPs) unaltered. A significant decrease viability observed, particularly E2. RVD assay revealed disruptions cells These findings underscore effects exposure M. They are open further investigations clarify environmental implications PPCPs possibility exploring safer alternatives.

Language: Английский

Citations

11
Antimicrobials and antimicrobial resistance genes in the shadow of COVID-19 pandemic: A wastewater-based epidemiology perspective DOI Creative Commons
Like Xu, Nicola Ceolotto, Kishore Jagadeesan

et al.

Water Research, Journal Year: 2024, Volume and Issue: 257, P. 121665 - 121665

Published: April 22, 2024

Higher usage of antimicrobial agents in both healthcare facilities and the communities has resulted an increased spread resistant bacteria. However, improved infection prevention control practices may also contribute to decreasing resistance (AMR). In present study, wastewater-based epidemiology (WBE) approach was applied explore link between COVID-19 community antimicrobials, as well prevalence genes. Longitudinal study been conducted monitor levels 50 (AAs), 24 metabolites, 5 antibiotic genes (ARGs) class 1 integrons (intI 1) wastewater influents 4 towns/cities over two years (April 2020 - March 2022) South-West England (a total 1,180 samples collected with 87,320 individual AA measurements 8,148 ARG measurements). Results suggested higher loads AAs ARGs 2021-22 than 2020-21, beta-lactams, quinolones, macrolides most showing statistical differences. particular, intI gene proxy environmental pollution) showed a significant increase after ease third national lockdown England. Positive correlations for all quantifiable parent metabolites were observed, consumption vs direct disposal unused identified via WBE. This work can help establish baselines AMR status communities, providing community-wide surveillance evidence informing public health interventions. Overall, studies focused on from start pandemic present, especially context settings, are great importance further understand long-term impact AMR.

Language: Английский

Citations

9