Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents

ACS Infectious Diseases, Journal Year: 2023, Volume and Issue: 9(4), P. 943 - 951

Published: March 16, 2023

Quaternary ammonium compounds (QACs) serve as a first line of defense against infectious pathogens. As resistance to QACs emerges in the environment, development next-generation disinfectants is utmost priority for human health. Balancing antibacterial potency with environmental considerations required effectively counter bacterial resistance. To address this challenge, series 14 novel biscationic quaternary phosphonium (bisQPCs) have been prepared amphiphilic through straightforward, high-yielding alkylation reactions. These feature decomposable or "soft" amide moieties their side chains, anticipated promote decomposition under conditions. Strong bioactivity panel seven pathogens was observed, highlighted by single-digit micromolar activity P6P-12A,12A and P3P-12A,12A. Hydrolysis experiments pure water buffers varying pH revealed surprising soft QPCs basic conditions at center, leading inactive phosphine oxide products; QPC stability (>24 h) maintained neutral solutions. The results work unveil potent environmentally conscious new class bisQPC disinfectants.

Language: Английский

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A review on factors related to patient comfort experience in hospitals

Journal of Health Population and Nutrition, Journal Year: 2023, Volume and Issue: 42(1)

Published: Nov. 8, 2023

Abstract The creation of a welcoming hospital atmosphere is necessary to improve patient wellbeing and encourage healing. goal this study was examine the variables affecting hospitalised patients' comfort. procedure included thorough search Web Science Scopus databases, as well use software analytic tools graphically map enormous literature data, providing deeper understanding linkages within its changing patterns. Insights from range disciplines, including engineering, psychology, immunology, microbiology, environmental science, were into our using content analysis clustering approaches. physical environment social are two crucial factors that related stress need giving comfort top priority they heal, especially by tackling indoor air pollution. Our research also emphasises how important care food guidelines for improving Prioritising patients who specialised attention, those have suffered trauma, should be focus future study. Future in fields communication, architecture, nursing will built on findings To enhance these areas, worldwide collaboration between experts other nations advised. Although many studies significance comfort, few drawn conclusions variety medicine, most issue thoroughly researching improvement has not been addressed. Healthcare workers, engineers, professions benefit greatly study's investigation connection environments

Language: Английский

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Resolving the “health vs environment” dilemma with sustainable disinfection during the COVID-19 pandemic

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(9), P. 24737 - 24741

Published: Jan. 9, 2023

Language: Английский

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Machine Learning Model for Prediction of the Chemicals Harmfulness on Staff and Guests in the Hospitality Industry: A Pilot Study

Data & Metadata, Journal Year: 2023, Volume and Issue: 2, P. 161 - 161

Published: Dec. 30, 2023

This article examines the trend around adoption of machine learning in hotel business light significance new technologies. According to previous research, hospitality industry uses a variety chemicals for cleaning. Cleaning supplies are housekeeping department's primary tool their daily routine keep rooms and common areas clean tidy. Guest staff don't know harmfulness these chemicals. Providing that meets needs guests requires not only positive attitude, but also high-quality excellent services warm, relaxed, comfortable. But some incidents, we find guest health is affected by Also, no one worked on predicting chemical's effects sector with use Machine Learning models. For this purpose, data collected from different hotels Delhi NCR India. There were two distinct fields utilized assessment instruction. investigation, methods employed. The research project employed five methods. newly developed MHC-CNN algorithm achieved highest accuracy (93,75) comparison other cutting-edge techniques. created technique can be expanded upon applied many all world

Language: Английский

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Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(17), P. 15530 - 15539

Published: Aug. 29, 2023

Quaternary ammonium compounds (QACs) are widely used in disinfectants, cleaners, preservatives, cosmetics, and agriculture. Recently, QACs have been detected the human bloodstream, breast milk, neonatal mouse brain, which shows that these can cross biological barriers. In vivo studies showed chronic low-level exposure to causes developmental, reproductive, immune dysfunctions, whereas vitro indicate affect reproductive systems, disrupt cholesterol biosynthesis, increase inflammatory cytokines, decrease mitochondrial functions. Effects of on health gradually emerging, amid increased use QAC disinfectants during COVID-19 pandemic. Analysis fluids including blood, urine, sweat, saliva provide vital information determining effects analytes. Biofluid analysis is convenient yet crucial because non-invasive/or minimally invasive procedures be performed outside hospital settings. Interest optical detection methods for biofluid has growing due recent advances technologies availability tunable materials aid technologies. Detection near-infrared (NIR) spectral range advantageous over visible mainly minimal autofluorescence, light-scattering, absorption from native molecules NIR range. Photoluminescent single-walled carbon nanotubes (SWCNTs) promising candidates development probes sensors their non-photobleaching fluorescence, surface chemistry, high sensitivity. Herein, we report protein-rich media a model biofluid. We functionalized photoluminescent SWCNTs with bile salt derivatives enabled artificial sweat serum-protein-enriched media. The was significant at nanomolar concentrations, within threshold various physiological processes. Thus, nanotube-based could well suited fluids.

Language: Английский

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