Self-Assembly of Multimolecular Components for Engineering Enzyme-Mimetic Materials DOI
Shichao Xu, Yuanxi Liu, Baoli Zhang

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(9), P. 1072 - 1086

Published: July 4, 2024

ConspectusNatural enzymes, with their intricate three-dimensional structures, facilitate a wide array of biochemical reactions exceptional precision and speed. The catalytic capabilities enzymes arise from the distinctive structures active sites, where functional groups collaborate or aid cofactors (organic ionic) in binding substrates specificity catalyzing transformations. Inspired by structure–function relationship supramolecular self-assembly, bottom-up approach nanofabrication, has been employed to create enzyme-mimetic catalysts. However, accurately replicating enzymatic sites poses formidable challenge, primarily because intricacies mimicking complexity natural protein folding.Many biological systems, such as tryptophan synthase ribosomes, rely on association multiple component subunits, each maintaining its structural integrity, enable efficient versatile functionalities. hierarchical self-assembly principles observed these systems have inspired us design self-assemble complementary molecular building blocks that form individual folding aggregating allowing for precise control over distribution reactive enzyme-like sites. customization either without disrupting enables flexible engineering properties. This Account will focus employing components, drawing research progress our lab, construct catalysts built-in metal-dependent metal-free be highlighted.To fabricate heme pockets copper within synthetic materials, we scaffold stabilizing hemin forming cluster, followed introduction second enhance substrate adsorption metal reactivity. resulting enzyme mimics exhibit remarkable synergistic activities possess great stability against harsh conditions, high temperatures, ionic strength, cyclic acidification/neutralization treatment. They can engineered tailorable selectivity toward specific chirality sizes externally stimulated switch between ON/OFF states. These shown performances sensing biomolecules interest, biomass degradation, aiding understanding mechanism native enzymes. To achieve catalysis, introduce "driving" guide formation assemblies activity hydrolases, photodecarboxylase, photo-oxidase, applications peptide modifications antibacterial therapy. Moreover, organized components like histidine catalyze achieved heme-dependent providing insights into novel biocatalytic mechanisms. Additionally, discuss DNAzyme units DNA nanostructured templates, which provide suitable microenvironments fabrication polymer nanopattern well-defined shapes.In end, key challenges related modeling, enhancing performance, increasing We also propose future perspectives achieving high-value practical applications. Our collective efforts outline strategies developing robust catalysts, general methods may extend other aiming mimic catalysis.

Language: Английский

Review for Micro‐Nano Processing Technology of Microstructures and Metadevices DOI Open Access
Siwei He,

Ying Tian,

Hao-Miao Zhou

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract As a popular artificial composite material emerging in recent years, metasurfaces are one of the most likely devices to break through volume limitation conventional optical components due their compact structure, flexible materials, and high modulation resolution beam. With unique arrangement units or made special metasurface can effectively modulate incident light's amplitude, phase, polarization, frequency, thus realizing applications such as communication, imaging, sensing, beam steering. The interaction high‐resolution periodic arrangement, constituent materials makes it possible realize these applications, so researchers should choose appropriate micro‐nano processing technologies when designing preparing metasurface. This review will present related preparation metasurfaces, electron lithography (EBL), femtosecond laser processing, focused ion (FIB), additive manufacturing, nanoimprinting, self‐assembly, respectively. In addition, classical techniques wet lithography, plasma deep reactive etching (DRIE), photolithography be introduced. Their development history functions described detail, examples micro‐nano‐structures different branches presented, well some using techniques. this paper has produced several tables describing technologies, outlining resolution, advantages disadvantages, on. Hopefully, provide with options ideas for metasurfaces.

Language: Английский

Citations

2
Peptide nanozymes: An emerging direction for functional enzyme mimics DOI
Shao‐Bin He,

Long Ma,

Qionghua Zheng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 284 - 298

Published: Sept. 4, 2024

Language: Английский

Citations

13
Generating Reactive Oxygen Species by a Dual-Catalytic Metal–organic Framework-based Nanozyme against Drug-resistant Bacteria Infection DOI
Meng Ding, Meng Tian, Lingjie Song

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(11), P. 5630 - 5642

Published: May 20, 2024

Oxidase-like artificial enzymes (AEs) are rapidly developing for their attractive reactive oxygen species (ROS)-generating capacity in biological applications. However, efficient strategies to improve the AE catalytic performance by modulating electron transfer (ET) process remain limited. Herein, a new pathway de novo-designed MOF-based oxidase mimics (ZCA-X) is reported. The structure of active center regulated form unique Au–N–Cu domain boosting ROS against drug-resistant bacteria. Unlike classical cascade systems depending on hydrogen peroxide or photocatalysts with complex regulation band structure, oxidase-like ZCA-20 catalyzes reduction via direct four-ET without simulation specific substrate. formed charge between Au NCs and CuN4 single site exhibits high efficiency (kcat = 3.61 s–1), generating as intermediate products. employed eradication bacteria ROS-mediated structural damage, showing remarkable therapeutic effects both vitro vivo. This strategy ET coupling different sites might inspire development AEs selectivity enzymatic activity.

Language: Английский

Citations

4
Coordination-driven self-assembly of biomolecules and metal ions: Advances in methodology and applications DOI
Yue Su, Yiting Liu, Yu Lin Zhong

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216403 - 216403

Published: Dec. 26, 2024

Language: Английский

Citations

4
Self-Assembly of Multimolecular Components for Engineering Enzyme-Mimetic Materials DOI
Shichao Xu, Yuanxi Liu, Baoli Zhang

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(9), P. 1072 - 1086

Published: July 4, 2024

ConspectusNatural enzymes, with their intricate three-dimensional structures, facilitate a wide array of biochemical reactions exceptional precision and speed. The catalytic capabilities enzymes arise from the distinctive structures active sites, where functional groups collaborate or aid cofactors (organic ionic) in binding substrates specificity catalyzing transformations. Inspired by structure–function relationship supramolecular self-assembly, bottom-up approach nanofabrication, has been employed to create enzyme-mimetic catalysts. However, accurately replicating enzymatic sites poses formidable challenge, primarily because intricacies mimicking complexity natural protein folding.Many biological systems, such as tryptophan synthase ribosomes, rely on association multiple component subunits, each maintaining its structural integrity, enable efficient versatile functionalities. hierarchical self-assembly principles observed these systems have inspired us design self-assemble complementary molecular building blocks that form individual folding aggregating allowing for precise control over distribution reactive enzyme-like sites. customization either without disrupting enables flexible engineering properties. This Account will focus employing components, drawing research progress our lab, construct catalysts built-in metal-dependent metal-free be highlighted.To fabricate heme pockets copper within synthetic materials, we scaffold stabilizing hemin forming cluster, followed introduction second enhance substrate adsorption metal reactivity. resulting enzyme mimics exhibit remarkable synergistic activities possess great stability against harsh conditions, high temperatures, ionic strength, cyclic acidification/neutralization treatment. They can engineered tailorable selectivity toward specific chirality sizes externally stimulated switch between ON/OFF states. These shown performances sensing biomolecules interest, biomass degradation, aiding understanding mechanism native enzymes. To achieve catalysis, introduce "driving" guide formation assemblies activity hydrolases, photodecarboxylase, photo-oxidase, applications peptide modifications antibacterial therapy. Moreover, organized components like histidine catalyze achieved heme-dependent providing insights into novel biocatalytic mechanisms. Additionally, discuss DNAzyme units DNA nanostructured templates, which provide suitable microenvironments fabrication polymer nanopattern well-defined shapes.In end, key challenges related modeling, enhancing performance, increasing We also propose future perspectives achieving high-value practical applications. Our collective efforts outline strategies developing robust catalysts, general methods may extend other aiming mimic catalysis.

Language: Английский

Citations

4