Photoswitchable Antioxidant and Prooxidant Activities of Mg-Doped Carbon Dot Nanozymes as Antibacterial and Anti-Inflammatory Agents DOI
Jinyu Shi, Yuxin Zhang,

Xiangyang Fang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(18), P. 26467 - 26479

Published: April 28, 2025

Multienzymatic nanozymes hold great potential in therapeutics due to their higher catalytic efficiency and multifunctionality. However, flexibly switching the antioxidant prooxidant activities of multienzymic at same lesion remains a challenge. Herein, we design magnesium-doped carbon dot (Mg-CD) with photoswitchable under physiological conditions. The Mg-CD exhibit superoxide dismutase (SOD)-like activity can scavenge singlet oxygen hydroxyl radicals without illumination. Interestingly, be converted oxidase-like visible light illumination, producing anions. mechanism switchable is attributed fact that coordination between magnesium CD skeleton enhances excited-state electron transfer states energy triplet electrons. Therefore, Mg-CDs act as antibacterial anti-inflammatory agents. rates exceeding 99% within 5 min They reactive species, thereby showing excellent capacity treating inflammatory wounds caused by lipopolysaccharide. These offer an effective strategy for better manipulating versatility nanozymes, expanding intelligent biomedical applications.

Language: Английский

Photoswitchable Antioxidant and Prooxidant Activities of Mg-Doped Carbon Dot Nanozymes as Antibacterial and Anti-Inflammatory Agents DOI
Jinyu Shi, Yuxin Zhang,

Xiangyang Fang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(18), P. 26467 - 26479

Published: April 28, 2025

Multienzymatic nanozymes hold great potential in therapeutics due to their higher catalytic efficiency and multifunctionality. However, flexibly switching the antioxidant prooxidant activities of multienzymic at same lesion remains a challenge. Herein, we design magnesium-doped carbon dot (Mg-CD) with photoswitchable under physiological conditions. The Mg-CD exhibit superoxide dismutase (SOD)-like activity can scavenge singlet oxygen hydroxyl radicals without illumination. Interestingly, be converted oxidase-like visible light illumination, producing anions. mechanism switchable is attributed fact that coordination between magnesium CD skeleton enhances excited-state electron transfer states energy triplet electrons. Therefore, Mg-CDs act as antibacterial anti-inflammatory agents. rates exceeding 99% within 5 min They reactive species, thereby showing excellent capacity treating inflammatory wounds caused by lipopolysaccharide. These offer an effective strategy for better manipulating versatility nanozymes, expanding intelligent biomedical applications.

Language: Английский

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