Discovering untapped microbial communities through metagenomics for microplastic remediation: recent advances, challenges, and way forward

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(34), P. 81450 - 81473

Published: Jan. 13, 2023

Language: Английский

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Microplastic-induced gut microbiota and serum metabolic disruption in Sprague-Dawley rats

Environmental Pollution, Journal Year: 2023, Volume and Issue: 320, P. 121071 - 121071

Published: Jan. 13, 2023

Language: Английский

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Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Metabolites, Journal Year: 2021, Volume and Issue: 11(8), P. 485 - 485

Published: July 27, 2021

Environmental pollution causes significant toxicity to ecosystems. Thus, acquiring a deeper understanding of the concentration environmental pollutants in ecosystems and, clarifying their potential toxicities is great significance. metabolomics powerful technique investigating effects on living organisms environment. In this review, we cover different aspects approach, which allows acquisition reliable data. A step-by-step procedure from sample preparation data interpretation also discussed. Additionally, other factors, including model and various types emerging toxicants are Moreover, considerations for successful as well identification toxic based combination with phenotype assays. Finally, induced by application

Language: Английский

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Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women

Environment International, Journal Year: 2022, Volume and Issue: 169, P. 107530 - 107530

Published: Sept. 17, 2022

Human and animal exposure to bisphenol A (BPA) has been associated with adverse developmental reproductive effects. The molecular mechanisms by which BPA exerts its effects are not well-understood, even less known about analogues F (BPF). To address these knowledge gaps, we conducted an untargeted metabolome-wide association study (MWAS) identify metabolic perturbations BPA/BPF exposures in a pregnant African American cohort.From subset of participants enrolled the Atlanta Maternal-Child cohort, collected both urine samples, for targeted assessment (N = 230) BPF 48), serum high-resolution metabolomics (HRM) profiling 230), during early pregnancy (8-14 weeks' gestation). Using established HRM workflow consisting MWAS modeling, pathway enrichment analysis, chemical annotation confirmation, investigated potential pathways features exposures.The geometric mean creatinine-adjusted concentrations urinary were 0.85 ± 2.58 0.70 4.71 µg/g creatinine, respectively. After false positive discovery rate correction at 20 % level, 264 733 unique significantly concentrations, representing 10 12 pathways, Three including steroid hormones biosynthesis, lysine lipoate metabolism, exposure. standards, have confirmed identity 16 metabolites or exposure.Our findings support that women is perturbation aromatic amino acid xenobiotics other metabolism closely linked stress responses, inflammation, neural development, reproduction, weight regulation.

Language: Английский

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Environmental phenol exposure associates with urine metabolome alteration in young Northeast Indian females

Chemosphere, Journal Year: 2023, Volume and Issue: 317, P. 137830 - 137830

Published: Jan. 11, 2023

Language: Английский

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Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns

Metabolomics, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 25, 2025

Abstract Background Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims explore global metabolome changes EDC biomarkers at delivery. Methods included 75 pregnant individuals who delivered University of Cincinnati Hospital from 2014 2017. We measured maternal urinary paraben/phenol (12), phthalate (13), and replacements (4) samples collected during delivery visit. Global serum profiles were analyzed blood ( n = 72) newborn 63) cord Fifteen 29 excluded due low detection frequency or potential exposures hospital stay. assessed metabolome-wide associations between 14 maternal/newborn profiles. Additionally, performed enrichment analysis identify alterations in pathways. Results observed concentrations metabolites (mono-isobutyl phthalate), (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) phenols (bisphenol-A, bisphenol-S) metabolome, using q-value < 0.2 as a threshold. (mono-n-butyl phthalate, monobenzyl phthalate) (2,5-dichlorophenol, BPA) noted. Enrichment analyses revealed (p-gamma 0.05) amino acid, carbohydrate, lipid, glycan, vitamin, other cofactor metabolism Conclusion Maternal paraben, phenol, replacement biomarker metabolome.

Language: Английский

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The toxic mechanism of 6:2 Cl-PFESA in adolescent male rats: Endocrine disorders and liver inflammation regulated by the gut microbiota-gut-testis/liver axis

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132155 - 132155

Published: July 26, 2023

Language: Английский

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Occurrence of bisphenol analogues and their conjugated metabolites in foodstuff

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174922 - 174922

Published: July 20, 2024

Language: Английский

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Metabolomics Reveals That Bisphenol Pollutants Impair Protein Synthesis-Related Pathways in Daphnia magna

Metabolites, Journal Year: 2021, Volume and Issue: 11(10), P. 666 - 666

Published: Sept. 29, 2021

Bisphenols are used in the production of polycarbonate plastics and epoxy resins. Bisphenol A (BPA) has been widely studied is believed to act as an endocrine disruptor. F (BPF) bisphenol S (BPS) have increasingly employed replacements for BPA, although previous studies suggested that they yield similar physiological responses several organisms. Daphnia magna a common model organism ecotoxicology was exposed sub-lethal concentrations BPF, BPS investigate disruption metabolic profiles. Targeted metabolite analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) measure polar metabolites extracted from D. magna, which linked range biochemical pathways. Multivariate analyses individual changes showed non-monotonic concentration all three bisphenols (BPA, BPS). Pathway indicated perturbation distinct pathways, mostly associated with protein synthesis, amino acid metabolism, energy metabolism. Overall, we observed can be chemical class (bisphenols) well related each type (A, F, S). These findings further demonstrate need using metabolomic exposure assessment, especially chemicals within same may disrupt biochemistry uniquely at molecular-level.

Language: Английский

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Does Bisphenol A (BPA) Exposure Cause Human Diseases?

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2678 - 2678

Published: Nov. 25, 2024

Background: Autism spectrum disorders (ASDs), attention-deficit disorder (ADHD), Parkinson’s disease (PD), polycystic ovary (PCOS), and Alzheimer’s (AD) have all been linked to exposure bisphenol A (BPA). Methods: This paper is a review discussion of the published literature. Results: Animal studies shown BPA be broad-spectrum endocrine disruptor. metabolized via glucuronidation pathway, which involves addition glucose target molecule, catalyzed by uridine 5′-diphospho-glucuronosyltransferases (UGTs). Evidence compromised has found for ASD, DHD, PD, PCOS. Genetic polymorphisms that alter catalytic activity UGTs efflux transporters involved are common. There two ways interpret findings associations between efficiency disease, ‘direct’ pathway an ‘indirect’ pathway. With free actual causative agent. Compromised detoxification leads higher concentrations in vulnerable tissues. Decreased increased tissues BPA, where it can function as not serves marker decreased another unknown compound endogenous origin detoxified similar combination BPA. It this compound(s), acting disruptor, metabolic environment favors development over extended time period. Conclusion: existing literature supports indirect ‘marker’ hypothesis hypothesis.

Language: Английский

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