Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(37), P. 7418 - 7449
Published: Jan. 1, 2022
Bio-applied
molecularly
imprinted
polymers
(MIPs)
are
biomimetic
materials
with
tailor-made
synthetic
recognition
sites,
mimicking
biological
counterparts
known
for
their
sensitive
and
selective
analyte
detection.
MIPs,
specifically
designed
biomarker
analysis
within
biofluids,
have
the
potential
to
significantly
aid
patient
diagnostics
at
point-of-care,
enabling
self-health
monitoring
management.
Recent
research
in
this
field,
facilitated
by
hybridisation
of
science
biology,
has
developed
utilised
a
variety
different
polymerisation
synthesis
methods
tailored
bio-application
MIPs.
This
review
evaluates
principles
molecular
imprinting
disease
diagnostics,
including
recent
progress
integrated
MIP-sensor
technologies
high-affinity
detection
complex
biofluids
from
serum
saliva
cerebrospinal
fluid,
sweat,
urine,
nasopharyngeal
tears.
The
work
highlights
state-of-the-art
progression
technologies'
translation
into
commercially
available
sensors
contribution
systems
healthcare
settings.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(30)
Published: June 18, 2021
Abstract
Advances
in
revolutionary
technologies
pose
new
challenges
for
human
life;
response
to
them,
global
responsibility
is
pushing
modern
toward
greener
pathways.
Molecular
imprinting
technology
(MIT)
a
multidisciplinary
mimic
simulating
the
specific
binding
principle
of
enzymes
substrates
or
antigens
antibodies;
along
with
its
rapid
progress
and
wide
applications,
MIT
faces
challenge
complying
green
sustainable
development
requirements.
With
identification
environmental
risks
associated
unsustainable
MIT,
aspect
termed
has
emerged
developed.
However,
so
far,
no
clear
definition
been
provided
appraise
MIT.
Herein,
implementation
process
chemistry
demonstrated
mnemonic
device
form
an
acronym,
GREENIFICATION,
proposed
present
principles.
The
entire
greenificated
surveyed,
including
element
choice,
polymerization
implementation,
energy
input,
strategies,
waste
treatment,
recovery,
as
well
impacts
these
processes
on
operator
health
environment.
Moreover,
assistance
upgraded
instrumentation
deploying
goals
considered.
Finally,
future
perspectives
are
presented
provide
more
complete
picture
road
map
pave
way
further
development.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(42)
Published: June 23, 2022
Abstract
Molecular
imprinting
technology
(MIT)
produces
artificial
binding
sites
with
precise
complementarity
to
substrates
and
thereby
is
capable
of
exquisite
molecular
recognition.
Over
five
decades
evolution,
it
predicted
that
the
resulting
host
imprinted
materials
will
overtake
natural
receptors
for
research
application
purposes,
but
in
practice,
this
has
not
yet
been
realized
due
unsustainability
their
life
cycles
(i.e.,
precursors,
creation,
use,
recycling,
end‐of‐life).
To
address
issue,
greenificated
molecularly
polymers
(GMIPs)
are
a
new
class
plastic
antibodies
have
approached
sustainability
by
following
one
or
more
greenification
principles,
while
also
demonstrating
far‐reaching
applications
compared
counterparts.
In
review,
most
recent
developments
delicate
design
advanced
GMIPs
six
fast‐growing
emerging
fields
surveyed,
namely
biomedicine/therapy,
catalysis,
energy
harvesting/storage,
nanoparticle
detection,
gas
sensing/adsorption,
environmental
remediation.
addition,
distinct
features
highlighted,
optimal
means
utilize
these
attaining
incredibly
discussed.
Importantly,
obscure
technical
challenges
MIT
revealed,
conceivable
solutions
offered.
Lastly,
several
perspectives
on
future
directions
proposed.
Chemosensors,
Journal Year:
2021,
Volume and Issue:
9(6), P. 123 - 123
Published: May 26, 2021
The
field
of
molecularly
imprinted
polymer
(MIP)-based
chemosensors
has
been
experiencing
constant
growth
for
several
decades.
Since
the
beginning,
their
continuous
development
driven
by
need
simple
devices
with
optimum
selectivity
detection
various
compounds
in
fields
such
as
medical
diagnosis,
environmental
and
industrial
monitoring,
food
toxicological
analysis,
and,
more
recently,
traces
explosives
or
precursors.
This
review
presents
an
overview
main
research
efforts
made
so
far
MIP-based
chemosensors,
critically
discusses
pros
cons,
gives
perspectives
further
developments
this
field.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 629 - 629
Published: Jan. 26, 2023
The
accurate
detection
of
biological
substances
such
as
proteins
has
always
been
a
hot
topic
in
scientific
research.
Biomimetic
sensors
seek
to
imitate
sensitive
and
selective
mechanisms
systems
integrate
these
traits
into
applicable
sensing
platforms.
Molecular
imprinting
technology
extensively
practiced
many
domains,
where
it
can
produce
various
molecular
recognition
materials
with
specific
capabilities.
Molecularly
imprinted
polymers
(MIPs),
dubbed
plastic
antibodies,
are
artificial
receptors
high-affinity
binding
sites
for
particular
molecule
or
compound.
MIPs
protein
expected
have
high
affinity
via
numerous
interactions
between
polymer
matrices
multiple
functional
groups
the
target
protein.
This
critical
review
briefly
describes
recent
advances
synthesis,
characterization,
application
MIP-based
sensor
platforms
used
detect
proteins.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(6), P. 2860 - 2893
Published: Jan. 1, 2022
Carbon
dots
(CDs),
as
one
new
class
of
carbon
nanomaterials
with
various
structure
and
extraordinary
physicochemical
properties,
have
attracted
tremendous
interest
for
their
potential
applications
in
tumor
theranostics,
especially
targeted
bioimaging
therapy.
In
these
areas,
CDs
its
derivatives
been
employed
highly
efficient
imaging
agent
photoluminescence
tumors
cells.
With
unique
structure,
optical
and/or
dose
attention
harnessed
nanotheranostic
strategies
diverse
through
integrating
other
functional
nanoparticles
or
utilizing
inherent
physical
properties.
Up
to
now,
approved
novel
biomaterials
by
excellent
performances
precise
therapy
tumors.
Herein,
the
latest
progress
development
are
reviewed.
Meanwhile,
challenges
future
prospects
application
promising
discussed
proposed.
Small,
Journal Year:
2023,
Volume and Issue:
19(13)
Published: Jan. 17, 2023
Molecularly
imprinted
polymers
(MIPs)
are
chemical
antibody
mimics
obtained
by
nanomoulding
the
3D
shape
and
functionalities
of
a
desired
target
in
synthetic
polymer.
Consequently,
they
possess
exquisite
molecular
recognition
cavities
for
binding
molecule,
often
with
specificity
affinity
similar
to
those
antigen-antibody
interactions.
Research
on
MIPs
targeting
proteins
began
mid-90s,
this
review
will
evaluate
progress
made
till
now,
starting
from
their
synthesis
monolith
bulk
format
through
surface
imprinting
biocompatible
soluble
nanogels
prepared
solid-phase
synthesis.
latter
be
discussed
more
detail
because
tremendous
potential
replacing
antibodies
biomedical
domain
like
diagnostics
therapeutics,
where
workforce
is
concentrated.
Emphasis
also
put
development
epitope
imprinting,
which
consists
short
surface-exposed
fragment
protein,
resulting
capable
selectively
recognizing
whole
macromolecule,
amidst
others
complex
biological
media,
cells
or
tissues.
Thus
selecting
'best'
peptide
antigen
crucial
context
rational
approach,
inspired
that
used
predict
immunogens
antibodies,
described
its
unambiguous
identification.
