Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 51(1), P. 329 - 375

Published: Dec. 13, 2021

This review article deals with the concepts, principles and applications of visible-light near-infrared (NIR) fluorescence surface-enhanced Raman scattering (SERS) in vitro point-of-care testing (POCT) vivo bio-imaging. It has discussed how to utilize biological transparency windows improve penetration depth signal-to-noise ratio, use surface plasmon resonance (SPR) amplify SERS signals. highlighted some plasmonic probes. also reviewed design strategies fluorescent sensors detection metal ions, small molecules, proteins nucleic acids. Particularly, it provided perspectives on integration into microfluidic chips as lab-on-chips realize testing. active devices non-paper- or paper-based lateral flow assays for diagnostics. In addition, this NIR bio-imaging platforms monitoring physiological processes disease progression live cells tissues. Moreover, POCT toxins, heavy metals, illicit drugs, cancers, traumatic brain injuries, infectious diseases such COVID-19, influenza, HIV sepsis.

Language: Английский

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Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(25), P. 11326 - 11337

Published: June 16, 2022

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as promising approach to cancer immunotherapy. However, biocompatible strategies activate pyroptosis remain rare. Here, we show that photocatalytic superoxide radical (O2-•) generator, NI-TA, triggers in cells. NI-TA was designed take advantage an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed the triggered by under conditions photoexcitation proceeds through caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). found function partial-O2-recycling mode action and trigger provide for effective ablation even hypoxia (≤2% O2). In case T47D 3D multicellular spheroids, good antitumor efficiency stemness inhibition are achieved. This work highlights how chemistry may be leveraged develop pyroptosis-inducing agents.

Language: Английский

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Visible-Light-Mediated Modification and Manipulation of Biomacromolecules

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(2), P. 1752 - 1829

Published: Sept. 21, 2021

Chemically modified biomacromolecules─i.e., proteins, nucleic acids, glycans, and lipids─have become crucial tools in chemical biology. They are extensively used not only to elucidate cellular processes but also industrial applications, particularly the context of biopharmaceuticals. In order enable maximum scope for optimization, it is pivotal have a diverse array biomacromolecule modification methods at one's disposal. Chemistry has driven many significant advances this area, especially recently, numerous novel visible-light-induced photochemical approaches emerged. these reactions, light serves as an external source energy, enabling access highly reactive intermediates under exceedingly mild conditions with exquisite spatiotemporal control. While UV-induced transformations on biomacromolecules date back decades, visible unmistakable advantage being considerably more biocompatible, spectrum visible-light-driven now available, chiefly proteins acids. This review will discuss modifications native functional groups (FGs), including functionalization, labeling, cross-linking techniques well utility oxidative degradation mediated by photochemically generated oxygen species. Furthermore, non-native, bioorthogonal FGs be addressed, photoclick chemistry DNA-encoded library synthesis that allow manipulation activity biomacromolecule.

Language: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(18)

Published: Nov. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Language: Английский

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Future‐Oriented Advanced Diarylethene Photoswitches: From Molecular Design to Spontaneous Assembly Systems

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(16)

Published: Dec. 6, 2021

Diarylethene (DAE) photoswitch is a new and promising family of photochromic molecules has shown superior performance as smart trigger in stimulus-responsive materials. During the past few decades, DAE achieved leap from simple to functional developed toward validity universal switching building block. In recent years, introduction into an assembly system been attractive strategy that enables behavior blocks be manifested at level entire system, beyond unit itself. This assembly-based will bring many unexpected results promote design manufacture generation advanced Here, advances fabrication diarylethene materials science, chemistry, biomedicine are reviewed.

Language: Английский

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Taking phototherapeutics from concept to clinical launch

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(11), P. 816 - 834

Published: Oct. 6, 2021

Language: Английский

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Clip Chemistry: Diverse (Bio)(macro)molecular and Material Function through Breaking Covalent Bonds

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(12), P. 7059 - 7121

Published: April 6, 2021

In the two decades since introduction of "click chemistry" concept, toolbox reactions" has continually expanded, enabling chemists, materials scientists, and biologists to rapidly selectively build complexity for their applications interest. Similarly, selective efficient covalent bond breaking reactions have provided will continue provide transformative advances. Here, we review key examples efficient, cleavage reactions, which refer herein as "clip reactions." The strategic application clip offers opportunities tailor compositions structures complex (bio)(macro)molecular systems with exquisite control. Working in concert, click chemistry offer scientists engineers powerful methods address next-generation challenges across chemical sciences.

Language: Английский

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Rational Design in Photopharmacology with Molecular Photoswitches

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(30)

Published: April 7, 2023

Photopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into structure biologically active small molecules to allow optical control their potency. Going beyond trial and error, photopharmacology has progressively applied rational design methodologies devise light-controlled bioactive ligands. this review, we categorize photopharmacological efforts from standpoint medicinal chemistry strategies, focusing on diffusible photochromic ligands modified that operate through E-Z bond isomerization. vast majority cases, photoswitchable designed as analogs existing compounds, a variety approaches. By analyzing in detail comprehensive list instructive examples, describe state art discuss future opportunities photopharmacology.

Language: Английский

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Stepping Out of the Blue: From Visible to Near‐IR Triggered Photoswitches

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(31)

Published: May 7, 2022

Abstract Light offers unique opportunities for controlling the activity of materials and biosystems with high spatiotemporal resolution. Molecular photoswitches are chromophores that undergo reversible isomerization between different states upon irradiation light, allowing a convenient means to control their influence over system interest. However, significant limitation classical is requirement initiate switching in one or both directions using deleterious UV light poor tissue penetration. Red‐shifted hence demand have attracted keen recent research In this Review, we highlight progress towards development visible‐ NIR‐activated characterized by distinct photochromic reaction mechanisms. We hope inspire further endeavors field, full potential these tools biotechnology chemistry applications be realized.

Language: Английский

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Role of chemistry in bio-inspired liquid wettability

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(13), P. 5452 - 5497

Published: Jan. 1, 2022

Different bio-inspired liquid wettability are derived through modulation of chemistry and topography—but the chemical process emerged as a superior approach for embedding desired other relevant physical properties.

Language: Английский

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