Chemistry - An Asian Journal,
Journal Year:
2022,
Volume and Issue:
17(24)
Published: Oct. 18, 2022
Gold
catalysis
is
an
extremely
enthusiastic
field
of
investigation
in
the
area.
The
development
alternative,
highly
inventive,
precompetitive
techniques
based
on
gold
has
paved
way
for
executing
a
broad
spectrum
chemical
transformations
from
uncomplicated
starting
materials.
total
synthesis
natural
products
complex
and
more
complicated
task.
An
amalgamation
product
through
gold-catalysis
been
thought-provoking
job.
protocol
solved
several
problems
related
to
numerous
products.
Thus,
this
review
outlined
some
most
notable
benchmarks
last
seven
years
(2015-2021)
their
application
strategy
acquired
by
authors
accomplish
will
be
elaborately
discussed
emphasizing
role
gold-catalyzed
reactions.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(14), P. 8478 - 8558
Published: Feb. 8, 2021
The
catalyst-directed
divergent
synthesis,
commonly
termed
as
"divergent
catalysis",
has
emerged
a
promising
technique
it
allows
chartering
of
structurally
distinct
products
from
common
substrates
simply
by
modulating
the
catalyst
system.
In
this
regard,
gold
complexes
powerful
catalysts
they
offer
unique
reactivity
profiles
compared
to
various
other
transition
metal
catalysts,
primarily
due
their
salient
electronic
and
geometrical
features.
Owing
tunable
soft
π-acidic
nature,
not
only
evolved
superior
contenders
for
catalyzing
reactions
alkynes,
alkenes,
allenes
but
also,
more
intriguingly,
have
been
found
provide
reaction
pathways
over
π-acid
such
Ag,
Pt,
Pd,
Rh,
Cu,
In,
Sc,
Hg,
Zn,
etc.
recent
past
witnessed
renaissance
in
examples
wherein,
choosing
or
fine-tuning
ligands,
counteranions
oxidation
states
itself,
complete
switch
was
observed.
However,
reviews
documenting
are
sporadic;
result,
most
reports
kind
remained
scattered
literature,
thereby
hampering
further
development
burgeoning
field.
By
conceptualizing
idea
"Divergent
Gold
Catalysis
(DGC)",
review
aims
consolidate
all
unified
approach
necessary
pave
way
advancement
exciting
area.
Based
on
factors
governing
divergence
product
formation,
an
explicit
classification
DGC
provided.
To
gain
fundamental
understanding
observed
reactivities
selectivities,
is
accompanied
mechanistic
insights
at
appropriate
places.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(18), P. 10422 - 10450
Published: Jan. 1, 2021
This
review
highlights
a
decade-long
journey
of
Au-catalyzed
1,2-difunctionalization
reactions
C–C
multiple
bonds
that
have
been
realized
due
to
the
productive
integration
Au(
i
)/Au(
iii
)catalysis
with
unique
π-activation
mode
gold
complexes.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(6), P. 3660 - 3674
Published: Feb. 5, 2024
Ligand-enabled
oxidative
addition
of
Csp2-X
bonds
to
Au(I)
centers
has
recently
appeared
as
a
valuable
strategy
for
the
development
catalytic
RedOx
processes.
Several
cross-coupling
reactions
that
were
previously
considered
difficult
achieve
reported
lately,
thus
expanding
synthetic
potential
gold(I)
complexes
beyond
traditional
nucleophilic
functionalization
π-systems.
MeDalPhos
played
an
important
role
in
this
and,
despite
several
studies
on
alternative
structures,
remains,
so
far,
only
general
ligand
such
process.
We
report
herein
discovery
and
DFT-enabled
structural
optimization
new
family
hemilabile
(P∧N)
ligands
can
promote
aryl
iodides
gold(I).
These
flexible
ligands,
which
possess
common
2-methylamino
heteroaromatic
N-donor
motif,
are
structurally
electronically
tunable,
being
easily
accessible
affordable.
The
corresponding
shown
outperform
reactivity
(MeDalPhos)Au(I)
series
alkoxy-
amidoarylations
alkenes.
Their
comparatively
higher
further
highlighted
thiotosylation
iodides,
challenging
unreported
C–S
reaction
could
not
be
achieved
under
classical
Pd(0/II)
catalysis
allows
divergent
access
sulfur
derivatives.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(8), P. 3497 - 3509
Published: Feb. 9, 2022
A
new
strategy
for
enantioselective
transition-metal
catalysis
is
presented,
wherein
a
H-bond
donor
placed
on
the
ligand
of
cationic
complex
allows
precise
positioning
chiral
counteranion
responsible
asymmetric
induction.
The
successful
implementation
this
paradigm
demonstrated
in
5-exo-dig
and
6-endo-dig
cyclizations
1,6-enynes,
combining
an
achiral
phosphinourea
Au(I)
chloride
with
BINOL-derived
phosphoramidate
Ag(I)
salt
thus
allowing
first
general
use
anions
Au(I)-catalyzed
reactions
challenging
alkyne
substrates.
Experiments
modified
complexes
anions,
1H
NMR
titrations,
kinetic
data,
studies
solvent
nonlinear
effects
substantiate
key
H-bonding
interaction
at
heart
catalytic
system.
This
conceptually
novel
approach,
which
lies
intersection
metal
catalysis,
organocatalysis,
counterion-directed
provides
blueprint
development
supramolecularly
assembled
ligands
complexes.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(33)
Published: June 11, 2022
Strained
rings
are
increasingly
important
for
the
design
of
pharmaceutical
candidates,
but
cross-coupling
strained
remains
challenging.
An
attractive,
underdeveloped,
approach
to
diverse
functionalized
carbocyclic
and
heterocyclic
frameworks
containing
all-carbon
quaternary
centers
is
coupling
abundant
strained-ring
carboxylic
acids
with
aryl
halides.
Herein
we
disclose
development
a
nickel-catalyzed
cross-electrophile
that
couples
variety
ring
N-hydroxyphthalimide
(NHP)
esters,
derived
from
acid
in
one
step,
various
heteroaryl
halides
under
reductive
conditions.
The
chemistry
enabled
by
discovery
methods
control
NHP
ester
reactivity,
tuning
solvent
or
using
modified
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(5), P. 2368 - 2378
Published: Jan. 31, 2022
α-Alkynyldiazomethanes,
generated
in
situ
from
the
corresponding
sulfonyl
hydrazones
presence
of
a
base,
can
serve
as
effective
metalloradicophiles
Co(II)-based
metalloradical
catalysis
(MRC)
for
asymmetric
cyclopropanation
alkenes.
With
D2-symmetric
chiral
amidoporphyrin
2,6-DiMeO-QingPhyrin
optimal
supporting
ligand,
system
efficiently
activate
different
α-alkynyldiazomethanes
at
room
temperature
highly
broad
range
This
catalytic
radical
process
provides
general
synthetic
tool
stereoselective
construction
alkynyl
cyclopropanes
high
yields
with
both
diastereoselectivity
and
enantioselectivity.
Combined
computational
experimental
studies
offer
several
lines
evidence
support
underlying
stepwise
mechanism
Co(II)-catalyzed
olefin
involving
unique
α-metalloradical
intermediate
that
is
associated
two
resonance
forms
α-Co(III)-propargyl
γ-Co(III)-allenyl
radical.
The
resulting
enantioenriched
cyclopropanes,
showcased
stereospecific
transformations,
may
valuable
building
blocks
organic
synthesis.
Chemistry - A European Journal,
Journal Year:
2022,
Volume and Issue:
28(20)
Published: Jan. 11, 2022
Abstract
Transition
metal‐catalyzed
enantioselective
functionalization
of
ubiquitous
C−H
bonds
has
proven
to
be
promising
field
as
it
offers
the
construction
chiral
molecular
complexity
in
a
step‐
and
atom‐economical
manner.
In
recent
years,
gold
emerged
an
attractive
contender
for
catalyzing
such
reactions.
The
unique
reactivities
selectivities
offered
by
catalysts
have
been
exploited
access
numerous
asymmetric
transformations
based
on
gold‐catalyzed
processes.
Herein,
this
review
critically
highlights
major
advances
discoveries
made
under
catalysis
which
is
accompanied
mechanistic
insights
at
appropriate
places.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1858 - 1895
Published: Jan. 1, 2024
This
review
is
planned
to
provide
a
comprehensive
overview
of
the
progress
made
in
design
and
development
chiral
ligands
for
asymmetric
gold
catalysis.
