Prospects of Fluorescent Single-Chirality Carbon Nanotube-Based Biosensors

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(28), P. 9941 - 9951

Published: July 5, 2022

Semiconducting single-wall carbon nanotubes (SWCNTs) fluoresce in the near-infrared (NIR), and emission wavelength depends on their structure (chirality). Interactions with other molecules affect fluorescence, which has successfully been used for SWCNT-based molecular sensors. So far, most such sensors are assembled from crude mixtures of different SWCNT chiralities, causes polydisperse sensor responses as well spectral congestion limits performance. The advent chirality-pure SWCNTs is about to overcome this limitation paves way next generation biosensors. Here, we discuss first examples fluorescent We introduce routes via aqueous two-phase extraction-assisted purification highlight critical interplay between surface modification procedures. Applications include NIR detection imaging neurotransmitters, reactive oxygen species, lipids, bacterial motives, plant metabolites. Most importantly, outline a path toward how monodisperse (chirality-pure) will enable advanced multiplexed sensing enhanced bioanalytical

Language: Английский

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Intriguing Room Temperature Phosphorescence in Crystalline Porous Organic Frameworks

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(52)

Published: Sept. 13, 2023

Abstract Organic room temperature phosphorescence (RTP) materials have become a hot topic in the field of luminescence wherein crystalline porous organic frameworks (metal–organic (MOFs), hydrogen‐bonded (HOFs), covalent (COFs))‐based RTP are receiving considerable attention. Beyond all doubt, frameworks‐based perfectly integrate advantages and materials. This review provides timely brief outline for development including construction strategy MOFs/HOFs/COFs‐based their performance as well potential applications. Moreover, conclusion outlook also discussed to present challenges prospects further high‐performance

Language: Английский

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Multifunctional Carbon Dots for Biomedical Applications: Diagnosis, Therapy, and Theranostic

Small, Journal Year: 2023, Volume and Issue: 20(3)

Published: Sept. 13, 2023

Abstract Designing suitable nanomaterials is an ideal strategy to enable early diagnosis and effective treatment of diseases. Carbon dots (CDs) are luminescent carbonaceous nanoparticles that have attracted considerable attention. Through facile synthesis, they process properties including tunable light emission, low toxicity, energy transformation, leading diverse applications as optically functional materials in biomedical fields. Recently, their potentials been further explored, such enzyme‐like activity ability promote osteogenic differentiation. refined synthesizing strategies carbon dots, a rich treasure trove for new discoveries, stand chance guide significant development applications. In this review, the authors start with brief introduction CDs. By presenting mechanisms examples, focus on how can be used diagnosing treating diseases, bioimaging failure tissues cells, biosensing various pathogenic factors biomarkers, tissue defect repair, anti‐inflammation, antibacterial antiviral, novel oncology treatment. The application integrated follows closely behind. Furthermore, challenges future directions CDs discussed. hope review will provide critical perspectives inspire discoveries prompt advances

Language: Английский

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Carbon Dots for Carbon Dummies: The Quantum and The Molecular Questions Among Some Others

Chemistry - A European Journal, Journal Year: 2022, Volume and Issue: 28(47)

Published: June 6, 2022

Abstract Carbon Dots (CDs) are carbon nanoparticles which were discovered in 2004. Despite two decades of intensive work from the scientific community and a colossal amount gathered experimental data, no definitive consensus exists to date on several key aspects such as actual definition CDs origin their emissive properties. This review proposes critical evaluation these fundamental questions. Lay persons will also find here an alternative introduction domain, including synthetic strategies, photophysical properties, well challenges outlook this exciting new area.

Language: Английский

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Understanding FRET in Upconversion Nanoparticle Nucleic Acid Biosensors

Nano Letters, Journal Year: 2023, Volume and Issue: 23(6), P. 2253 - 2261

Published: Feb. 2, 2023

Upconversion nanoparticles (UCNPs) have been frequently applied in Förster resonance energy transfer (FRET) bioanalysis. However, the understanding of how surface coatings, bioconjugation, and dye-surface distance influence FRET biosensing performance has not significantly advanced. Here, we investigated UCNP-to-dye DNA-hybridization assays H2O D2O using ∼24 nm large NaYF4:Yb3+,Er3+ UCNPs coated with thin layers silica (SiO2) or poly(acrylic acid) (PAA). resulted strong distance-dependent PL intensity changes. decay times were altered because continuous Yb3+-to-Er3+ migration during Er3+-to-dye FRET. Direct bioconjugation DNA to PAA coating combined closest possible optimal minor from competitive quenching by H2O. The better comprehension was successfully translated into a microRNA (miR-20a) assay limit detection 100 fmol 80 μL sample volume.

Language: Английский

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