Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(7), P. 2266 - 2276
Published: Jan. 1, 2023
Although
the
main
function
of
skin
is
to
act
as
a
protective
barrier
against
external
factors,
it
indeed
an
extremely
vulnerable
tissue.
Skincare,
regardless
wound
type,
requires
effective
treatments
prevent
bacterial
infection
and
local
inflammation.
The
complex
biological
roles
displayed
by
hyaluronic
acid
(HA)
during
healing
process
have
made
this
multifaceted
polysaccharide
alternative
biomaterial
prepare
dressings.
Therefore,
herein,
we
present
most
advanced
research
undertaken
engineer
conductive
interactive
hydrogels
based
on
HA
dressings
that
enhance
tissue
regeneration
either
through
electrical
stimulation
(ES)
or
displaying
multifunctional
performance.
First,
briefly
introduce
reader
effect
ES
promoting
why
has
become
vogue
agent.
Then,
selection
systems,
chosen
according
their
relevance,
presented.
Special
care
been
taken
highlight
those
recently
reported
works
(mainly
from
last
3
years)
with
enhanced
scalability
biomimicry.
By
doing
that,
turned
critical
eye
field
considering
what
major
challenges
must
be
overcome
for
these
systems
real
commercial,
clinical,
other
translational
impact.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(6), P. 5211 - 5295
Published: March 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(9), P. 3759 - 3793
Published: Jan. 1, 2022
Skin
bioelectronics
are
considered
as
an
ideal
platform
for
personalised
healthcare
because
of
their
unique
characteristics,
such
thinness,
light
weight,
good
biocompatibility,
excellent
mechanical
robustness,
and
great
skin
conformability.
Recent
advances
in
skin-interfaced
have
promoted
various
applications
precision
medicine.
Particularly,
long-term,
continuous
health
monitoring
offer
powerful
analysis
a
broad
spectrum
statuses,
providing
route
to
early
disease
diagnosis
treatment.
In
this
review,
we
discuss
(1)
representative
sensing
devices,
(2)
material
structure
selection,
device
properties,
wireless
technologies
towards
monitoring,
(3)
applications:
acquisition
electrophysiological,
biophysical,
biochemical
signals,
comprehensive
(4)
rational
guidelines
the
design
future
monitoring.
Long-term,
advanced
will
open
unprecedented
opportunities
timely
prevention,
screening,
diagnosis,
treatment,
demonstrating
promise
revolutionise
traditional
medical
practices.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(2), P. 455 - 553
Published: Jan. 4, 2024
In
the
era
of
Internet-of-things,
many
things
can
stay
connected;
however,
biological
systems,
including
those
necessary
for
human
health,
remain
unable
to
connected
global
Internet
due
lack
soft
conformal
biosensors.
The
fundamental
challenge
lies
in
fact
that
electronics
and
biology
are
distinct
incompatible,
as
they
based
on
different
materials
via
functioning
principles.
particular,
body
is
curvilinear,
yet
typically
rigid
planar.
Recent
advances
design
have
generated
tremendous
opportunities
wearable
bioelectronics,
which
may
bridge
gap,
enabling
ultimate
dream
healthcare
anyone,
anytime,
anywhere.
We
begin
with
a
review
historical
development
healthcare,
indicating
significant
trend
healthcare.
This
followed
by
focal
point
discussion
about
new
design,
particularly
low-dimensional
nanomaterials.
summarize
material
types
their
attributes
designing
bioelectronic
sensors;
we
also
cover
synthesis
fabrication
methods,
top-down,
bottom-up,
combined
approaches.
Next,
discuss
energy
challenges
progress
made
date.
addition
front-end
devices,
describe
back-end
machine
learning
algorithms,
artificial
intelligence,
telecommunication,
software.
Afterward,
integration
systems
been
applied
various
testbeds
real-world
settings,
laboratories
preclinical
clinical
environments.
Finally,
narrate
remaining
conjunction
our
perspectives.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(22)
Published: May 31, 2023
Implantable
bioelectronics
provide
unprecedented
opportunities
for
real-time
and
continuous
monitoring
of
physiological
signals
living
bodies.
Most
adopt
thin-film
substrates
such
as
polyimide
polydimethylsiloxane
that
exhibit
high
levels
flexibility
stretchability.
However,
the
low
permeability
relatively
modulus
these
thin
films
hamper
long-term
biocompatibility.
In
contrast,
devices
fabricated
on
porous
show
advantages
but
suffer
from
patterning
density.
Here,
we
report
a
wafer-scale
patternable
strategy
high-resolution
fabrication
supersoft,
stretchable,
permeable
liquid
metal
microelectrodes
(μLMEs).
We
demonstrate
2-μm
capability,
or
an
ultrahigh
density
~75,500
electrodes/cm
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: July 26, 2023
Abstract
Soft
and
stretchable
electronics
have
emerged
as
highly
promising
tools
for
biomedical
diagnosis
biological
studies,
they
interface
intimately
with
the
human
body
other
systems.
Most
electronic
materials
devices,
however,
still
Young’s
moduli
orders
of
magnitude
higher
than
soft
bio-tissues,
which
limit
their
conformability
long-term
biocompatibility.
Here,
we
present
a
design
strategy
interlayer
allowing
use
existing
relatively
high
to
versatilely
realize
devices
ultralow
tissue-level
moduli.
We
demonstrated
transistor
arrays
active-matrix
circuits
below
10
kPa—over
two
lower
current
state
art.
Benefiting
from
increased
irregular
dynamic
surfaces,
ultrasoft
device
created
realizes
electrophysiological
recording
on
an
isolated
heart
adaptability,
spatial
stability,
minimal
influence
ventricle
pressure.
In
vivo
biocompatibility
tests
also
demonstrate
benefit
suppressing
foreign-body
responses
implantation.
With
its
general
applicability
diverse
this
soft-interlayer
overcomes
material-level
limitation
imparting
softness
variety
bioelectronic
devices.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(4), P. 1535 - 1648
Published: Feb. 19, 2024
Over
the
years,
researchers
have
made
significant
strides
in
development
of
novel
flexible/stretchable
and
conductive
materials,
enabling
creation
cutting-edge
electronic
devices
for
wearable
applications.
Among
these,
porous
textiles
(PCTs)
emerged
as
an
ideal
material
platform
electronics,
owing
to
their
light
weight,
flexibility,
permeability,
wearing
comfort.
This
Review
aims
present
a
comprehensive
overview
progress
state
art
utilizing
PCTs
design
fabrication
wide
variety
integrated
systems.
To
begin
with,
we
elucidate
how
revolutionize
form
factors
electronics.
We
then
discuss
preparation
strategies
PCTs,
terms
raw
processes,
key
properties.
Afterward,
provide
detailed
illustrations
are
used
basic
building
blocks
fabricate
intrinsically
flexible
or
stretchable
devices,
including
sensors,
actuators,
therapeutic
energy-harvesting
storage
displays.
further
describe
techniques
systems
either
by
hybridizing
conventional
off-the-shelf
rigid
components
with
integrating
multiple
fibrous
PCTs.
Subsequently,
highlight
some
important
application
scenarios
healthcare,
sports
training,
converging
technologies,
professional
specialists.
At
end
Review,
challenges
perspectives
on
future
research
directions
give
overall
conclusions.
As
demand
more
personalized
interconnected
continues
grow,
PCT-based
wearables
hold
immense
potential
redefine
landscape
technology
reshape
way
live,
work,
play.
