Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12025 - 12048

Published: May 6, 2024

Cardiac interfacing devices are essential components for the management of cardiovascular diseases, particularly in terms electrophysiological monitoring and implementation therapies. However, conventional cardiac typically composed rigid bulky materials thus pose significant challenges effective long-term with curvilinear surface a dynamically beating heart. In this regard, recent development intrinsically soft bioelectronic using nanocomposites, which fabricated by blending conductive nanofillers polymeric elastomeric matrices, has shown great promise. The bioelectronics not only endure dynamic motion heart maintain stable performance but also enable conformal, reliable, large-area target tissue, allowing high-quality mapping, feedback electrical stimulations, even mechanical assistance. Here, we explore next-generation strategies based on that utilize elastic nanocomposites. We first discuss used to manage diseases explain their undesired limitations. Then, introduce restraint utilizing materials. After discussion fabrication functionalization nanomaterials, introduction nanocomposites application therapy follow. Finally, comments future prospects technologies discussed.

Language: Английский

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Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 70 - 70

Published: Jan. 7, 2025

Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis

Language: Английский

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Stretchable conductive nanocomposites and their applications in wearable devices

Applied Physics Reviews, Journal Year: 2022, Volume and Issue: 9(2)

Published: June 1, 2022

Recently, highly conductive polymer nanocomposites, particularly soft have received extensive attention as promising material candidates for wearable devices. Compared with the cases of devices based on conventional rigid electronic materials, nanocomposites exhibit excellent conformal contacts skin due to mechanical properties these nanocomposites; therefore, polymeric can be applied stretchable wirings, electrodes, and sensor units in various on-skin electronics. The types polymers nanofillers used synthesis are critical factors determining nanocomposites. overall physical depend type used, whereas electrical governed by nanofiller employed. Herein, we review latest studies constructed using different that We classified into non-elastic polymers, hydrogels, chemically crosslinked elastomers, physically elastomers C, liquid metal, Ag, Au, other emerging nanomaterials. Detailed characteristics, fabrication methods, applications, limitations reviewed. Finally, a brief outlook future research is provided.

Language: Английский

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Materials and design strategies for stretchable electroluminescent devices

Nanoscale Horizons, Journal Year: 2022, Volume and Issue: 7(8), P. 801 - 821

Published: Jan. 1, 2022

We discuss materials and design strategies for stretchable electroluminescent (EL) devices. categorize EL devices into two types: (i) structurally (ii) intrinsically

Language: Английский

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Multifunctional conductive hyaluronic acid hydrogels for wound care and skin regeneration

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(7), P. 2266 - 2276

Published: Jan. 1, 2023

Although the main function of skin is to act as a protective barrier against external factors, it indeed an extremely vulnerable tissue. Skincare, regardless wound type, requires effective treatments prevent bacterial infection and local inflammation. The complex biological roles displayed by hyaluronic acid (HA) during healing process have made this multifaceted polysaccharide alternative biomaterial prepare dressings. Therefore, herein, we present most advanced research undertaken engineer conductive interactive hydrogels based on HA dressings that enhance tissue regeneration either through electrical stimulation (ES) or displaying multifunctional performance. First, briefly introduce reader effect ES promoting why has become vogue agent. Then, selection systems, chosen according their relevance, presented. Special care been taken highlight those recently reported works (mainly from last 3 years) with enhanced scalability biomimicry. By doing that, turned critical eye field considering what major challenges must be overcome for these systems real commercial, clinical, other translational impact.

Language: Английский

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