Biomaterials,
Journal Year:
2023,
Volume and Issue:
301, P. 122240 - 122240
Published: July 12, 2023
Controlling
traumatic
bleeding
from
damaged
internal
organs
while
effectively
sealing
the
wound
is
critical
for
saving
lives
of
patients.
Existing
bioadhesives
suffer
blood
incompatibility,
insufficient
adhesion
to
wet
surfaces,
weak
mechanical
properties,
and
complex
application
procedures.
Here,
we
engineered
a
ready-to-use
hemostatic
bioadhesive
with
ultra-strengthened
properties
fatigue
resistance,
robust
tissues
within
few
seconds
gentle
pressing,
deformability
accommodate
physiological
function
action,
ability
stop
efficiently.
The
hydrogel,
which
demonstrated
high
elasticity
(>900%)
toughness
(>4600
kJ/m3),
was
formed
by
fine-tuning
series
molecular
interactions
crosslinking
mechanisms
involving
N-hydroxysuccinimide
(NHS)
conjugated
alginate
(Alg-NHS),
poly
(ethylene
glycol)
diacrylate
(PEGDA),
tannic
acid
(TA),
Fe3+
ions.
Dual
adhesive
moieties
including
mussel-inspired
pyrogallol/catechol
NHS
synergistically
enhanced
tissue
(>400
kPa
in
closure
test).
In
conjunction
physical
sealing,
affinity
TA/Fe3+
could
further
augment
hemostasis.
excellent
vitro
vivo
biocompatibility
as
well
improved
efficacy
compared
commercial
Surgicel®.
Overall,
hydrogel
design
strategy
described
herein
holds
great
promise
overcoming
existing
obstacles
impeding
clinical
translation
bioadhesives.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
23, P. 314 - 327
Published: Nov. 24, 2022
Blood
loss
by
hemorrhaging
wounds
accounts
for
over
one-third
of
∼5
million
trauma
fatalities
worldwide
every
year.
If
not
controlled
in
a
timely
manner,
exsanguination
can
take
lives
within
few
minutes.
Developing
new
biomaterials
that
are
easy
to
use
non-expert
patients
and
promote
rapid
blood
coagulation
is
an
unmet
medical
need.
Here,
biocompatible,
biodegradable
microneedle
arrays
(MNAs)
based
on
gelatin
methacryloyl
(GelMA)
biomaterial
hybridized
with
silicate
nanoplatelets
(SNs)
developed
hemorrhage
control.
The
SNs
render
the
MNAs
hemostatic,
while
needle-shaped
structure
increases
contact
area
blood,
synergistically
accelerating
clotting
time
from
11.5
min
1.3
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
17, P. 100468 - 100468
Published: Oct. 18, 2022
Uncontrolled
bleeding
remains
as
a
leading
cause
of
death
in
surgical,
traumatic,
and
emergency
situations.
Management
the
hemorrhage
development
hemostatic
materials
are
paramount
for
patient
survival.
Owing
to
their
inherent
biocompatibility,
biodegradability
bioactivity,
biopolymers
such
polysaccharides
polypeptides
have
been
extensively
researched
become
focus
next-generation
materials.
The
construction
novel
requires
in-depth
understanding
physiological
process,
fundamental
mechanisms,
effects
material
chemistry/physics.
Herein,
we
recapitulated
common
strategies
status
biopolymer-based
Furthermore,
mechanisms
various
molecular
structures
(components
chemical
modifications)
summarized
from
microscopic
perspective,
design
based
on
them
introduced.
From
macroscopic
forms
materials,
e.g.,
powder,
sponge,
hydrogel
gauze,
is
compared,
which
may
provide
an
enlightenment
optimization
hemostat
design.
It
has
also
highlighted
current
challenges
proposed
future
directions
chemistry
design,
advanced
form
clinical
application.
Biomacromolecules,
Journal Year:
2022,
Volume and Issue:
24(2), P. 690 - 703
Published: Dec. 19, 2022
The
development
of
injectable
hydrogels
with
good
biocompatibility,
self-healing,
and
superior
hemostatic
properties
is
highly
desirable
in
emergency
clinical
applications.
Herein,
we
report
an
situ
self-healing
hydrogel
based
on
choline
phosphoryl
functionalized
chitosan
(CS-g-CP)
oxidized
dextran
(ODex).
CP
groups
were
hypothesized
to
accelerate
hemostasis
by
facilitating
erythrocyte
adhesion
aggregation.
Our
results
reveal
that
the
CS-g-CP/ODex
exhibit
enhanced
blood
clotting
adhesion/aggregation
capacities
compared
those
CS/ODex
hydrogels.
CS-g-CP50/ODex75
presents
rapid
gelation
time,
mechanical
strength
tissue
adhesiveness,
satisfactory
bursting
pressure,
favorable
biocompatibility.
ability
was
significantly
improved
commercial
fibrin
sealant
rat
tail
amputation
liver/spleen
injury
models.
study
highlights
positive
synergistic
effects
strongly
supports
as
a
promising
adhesive
for
hemorrhage
control.
Biomaterials,
Journal Year:
2023,
Volume and Issue:
301, P. 122240 - 122240
Published: July 12, 2023
Controlling
traumatic
bleeding
from
damaged
internal
organs
while
effectively
sealing
the
wound
is
critical
for
saving
lives
of
patients.
Existing
bioadhesives
suffer
blood
incompatibility,
insufficient
adhesion
to
wet
surfaces,
weak
mechanical
properties,
and
complex
application
procedures.
Here,
we
engineered
a
ready-to-use
hemostatic
bioadhesive
with
ultra-strengthened
properties
fatigue
resistance,
robust
tissues
within
few
seconds
gentle
pressing,
deformability
accommodate
physiological
function
action,
ability
stop
efficiently.
The
hydrogel,
which
demonstrated
high
elasticity
(>900%)
toughness
(>4600
kJ/m3),
was
formed
by
fine-tuning
series
molecular
interactions
crosslinking
mechanisms
involving
N-hydroxysuccinimide
(NHS)
conjugated
alginate
(Alg-NHS),
poly
(ethylene
glycol)
diacrylate
(PEGDA),
tannic
acid
(TA),
Fe3+
ions.
Dual
adhesive
moieties
including
mussel-inspired
pyrogallol/catechol
NHS
synergistically
enhanced
tissue
(>400
kPa
in
closure
test).
In
conjunction
physical
sealing,
affinity
TA/Fe3+
could
further
augment
hemostasis.
excellent
vitro
vivo
biocompatibility
as
well
improved
efficacy
compared
commercial
Surgicel®.
Overall,
hydrogel
design
strategy
described
herein
holds
great
promise
overcoming
existing
obstacles
impeding
clinical
translation
bioadhesives.
