Hemostatic patch with ultra-strengthened mechanical properties for efficient adhesion to wet surfaces DOI Creative Commons
Yuting Zheng, Kaavian Shariati, Mahsa Ghovvati

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122240 - 122240

Published: July 12, 2023

Controlling traumatic bleeding from damaged internal organs while effectively sealing the wound is critical for saving lives of patients. Existing bioadhesives suffer blood incompatibility, insufficient adhesion to wet surfaces, weak mechanical properties, and complex application procedures. Here, we engineered a ready-to-use hemostatic bioadhesive with ultra-strengthened properties fatigue resistance, robust tissues within few seconds gentle pressing, deformability accommodate physiological function action, ability stop efficiently. The hydrogel, which demonstrated high elasticity (>900%) toughness (>4600 kJ/m3), was formed by fine-tuning series molecular interactions crosslinking mechanisms involving N-hydroxysuccinimide (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), Fe3+ ions. Dual adhesive moieties including mussel-inspired pyrogallol/catechol NHS synergistically enhanced tissue (>400 kPa in closure test). In conjunction physical sealing, affinity TA/Fe3+ could further augment hemostasis. excellent vitro vivo biocompatibility as well improved efficacy compared commercial Surgicel®. Overall, hydrogel design strategy described herein holds great promise overcoming existing obstacles impeding clinical translation bioadhesives.

Language: Английский

Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment DOI Creative Commons
Reihaneh Haghniaz, Han‐Jun Kim, Hossein Montazerian

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 23, P. 314 - 327

Published: Nov. 24, 2022

Blood loss by hemorrhaging wounds accounts for over one-third of ∼5 million trauma fatalities worldwide every year. If not controlled in a timely manner, exsanguination can take lives within few minutes. Developing new biomaterials that are easy to use non-expert patients and promote rapid blood coagulation is an unmet medical need. Here, biocompatible, biodegradable microneedle arrays (MNAs) based on gelatin methacryloyl (GelMA) biomaterial hybridized with silicate nanoplatelets (SNs) developed hemorrhage control. The SNs render the MNAs hemostatic, while needle-shaped structure increases contact area blood, synergistically accelerating clotting time from 11.5 min 1.3

Language: Английский

Citations

57

Smart aligned multi-layered conductive cryogels with hemostasis and breathability for coagulopathy epistaxis, nasal mucosal repair and bleeding monitoring DOI
Meng Li,

Guoying Pan,

Yutong Yang

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 48, P. 101720 - 101720

Published: Dec. 7, 2022

Language: Английский

Citations

50

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms DOI Creative Commons
Chen‐Yu Zou, Qianjin Li, Juanjuan Hu

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100468 - 100468

Published: Oct. 18, 2022

Uncontrolled bleeding remains as a leading cause of death in surgical, traumatic, and emergency situations. Management the hemorrhage development hemostatic materials are paramount for patient survival. Owing to their inherent biocompatibility, biodegradability bioactivity, biopolymers such polysaccharides polypeptides have been extensively researched become focus next-generation materials. The construction novel requires in-depth understanding physiological process, fundamental mechanisms, effects material chemistry/physics. Herein, we recapitulated common strategies status biopolymer-based Furthermore, mechanisms various molecular structures (components chemical modifications) summarized from microscopic perspective, design based on them introduced. From macroscopic forms materials, e.g., powder, sponge, hydrogel gauze, is compared, which may provide an enlightenment optimization hemostat design. It has also highlighted current challenges proposed future directions chemistry design, advanced form clinical application.

Language: Английский

Citations

45

A Choline Phosphoryl-Conjugated Chitosan/Oxidized Dextran Injectable Self-Healing Hydrogel for Improved Hemostatic Efficacy DOI

Ziran Zhu,

Kaiwen Zhang,

Yiwen Xian

et al.

Biomacromolecules, Journal Year: 2022, Volume and Issue: 24(2), P. 690 - 703

Published: Dec. 19, 2022

The development of injectable hydrogels with good biocompatibility, self-healing, and superior hemostatic properties is highly desirable in emergency clinical applications. Herein, we report an situ self-healing hydrogel based on choline phosphoryl functionalized chitosan (CS-g-CP) oxidized dextran (ODex). CP groups were hypothesized to accelerate hemostasis by facilitating erythrocyte adhesion aggregation. Our results reveal that the CS-g-CP/ODex exhibit enhanced blood clotting adhesion/aggregation capacities compared those CS/ODex hydrogels. CS-g-CP50/ODex75 presents rapid gelation time, mechanical strength tissue adhesiveness, satisfactory bursting pressure, favorable biocompatibility. ability was significantly improved commercial fibrin sealant rat tail amputation liver/spleen injury models. study highlights positive synergistic effects strongly supports as a promising adhesive for hemorrhage control.

Language: Английский

Citations

43

Hemostatic patch with ultra-strengthened mechanical properties for efficient adhesion to wet surfaces DOI Creative Commons
Yuting Zheng, Kaavian Shariati, Mahsa Ghovvati

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122240 - 122240

Published: July 12, 2023

Controlling traumatic bleeding from damaged internal organs while effectively sealing the wound is critical for saving lives of patients. Existing bioadhesives suffer blood incompatibility, insufficient adhesion to wet surfaces, weak mechanical properties, and complex application procedures. Here, we engineered a ready-to-use hemostatic bioadhesive with ultra-strengthened properties fatigue resistance, robust tissues within few seconds gentle pressing, deformability accommodate physiological function action, ability stop efficiently. The hydrogel, which demonstrated high elasticity (>900%) toughness (>4600 kJ/m3), was formed by fine-tuning series molecular interactions crosslinking mechanisms involving N-hydroxysuccinimide (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), Fe3+ ions. Dual adhesive moieties including mussel-inspired pyrogallol/catechol NHS synergistically enhanced tissue (>400 kPa in closure test). In conjunction physical sealing, affinity TA/Fe3+ could further augment hemostasis. excellent vitro vivo biocompatibility as well improved efficacy compared commercial Surgicel®. Overall, hydrogel design strategy described herein holds great promise overcoming existing obstacles impeding clinical translation bioadhesives.

Language: Английский

Citations

41