Biomacromolecules,
Journal Year:
2023,
Volume and Issue:
24(6), P. 2618 - 2632
Published: May 4, 2023
Peptoids
(N-substituted
glycines)
are
a
group
of
highly
controllable
peptidomimetic
polymers.
Amphiphilic
diblock
peptoids
have
been
engineered
to
assemble
crystalline
nanospheres,
nanofibrils,
nanosheets,
and
nanotubes
with
biochemical,
biomedical,
bioengineering
applications.
The
mechanical
properties
peptoid
nanoaggregates
their
relationship
the
emergent
self-assembled
morphologies
relatively
unexplored
critical
for
rational
design
nanomaterials.
In
this
work,
we
consider
family
amphiphilic
consisting
prototypical
tube-former
(Nbrpm6Nc6,
NH2-capped
hydrophobic
block
six
N-((4-bromophenyl)methyl)glycine
residues
conjugated
polar
NH3(CH2)5CO
tail),
sheet-former
(Nbrpe6Nc6,
where
comprises
N-((4-bromophenyl)ethyl)glycine
residues),
an
intermediate
sequence
that
forms
mixed
structures
((NbrpeNbrpm)3Nc6).
We
combine
all-atom
molecular
dynamics
simulations
atomic
force
microscopy
determine
2D
nanosheets
relate
these
observed
morphologies.
find
good
agreement
between
our
computational
predictions
experimental
measurements
Young's
modulus
nanosheets.
A
analysis
bending
along
two
axes
planar
reveals
be
more
favorable
axis
in
which
stack
by
interdigitation
side
chains
compared
they
form
columnar
crystals
π-stacked
chains.
construct
models
Nbrpm6Nc6
tube-forming
predict
stability
optimum
measurements.
theoretical
model
nanotube
suggests
is
free
energy
minimum
corresponding
"Goldilocks"
tube
radius
at
capillary
wave
fluctuations
wall
minimized.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
2(1)
Published: Dec. 30, 2023
Abstract
Intelligent
materials
with
responsive
behaviors
toward
external
stimuli,
such
as
light,
temperature,
pH,
redox,
and
solvent
have
been
increasingly
fascinating.
Reversible
noncovalent
interactions
provide
an
efficient
way
to
construct
stimuli‐responsive
materials.
Macrocyclic
compounds,
cyclodextrins,
cucurbit[
n
]urils,
calix[
]arenes,
crown
ethers,
related
macrocycles,
are
useful
skeletons
for
constructing
through
host–guest
interactions.
Pillar[
]arenes
pillar‐shaped
macrocyclic
hosts
developed
by
our
groups
in
2008,
which
the
repeated
1,4‐dialkoxybenzene
units
connected
methylene
bridges
at
para
position.
The
versatile
functionality,
easy
modification,
excellent
size‐dependent
complexation,
adjustable
electron
density
of
cavity
endow
pillar[
properties
compared
other
cyclic
host
molecules.
Moreover,
unique
planar
chirality
inversion
generated
unit
rotation
make
ideal
platforms
investigating
inversion,
induction,
transformation.
In
this
review,
we
describe
topological,
optical,
chiroptical,
supramolecular
assemblies,
solid‐state
based
on
complexation
structural
regulation
]arenes.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(8), P. 2975 - 2983
Published: Jan. 1, 2024
This
study
illustrates
that
a
carefully
designed
bifunctional
linker
can
steer
the
construction
of
various
protein
heterooligomers
without
extensive
sequence
optimizations,
expanding
structural
and
functional
diversity
architectures.
Chem,
Journal Year:
2024,
Volume and Issue:
10(4), P. 1225 - 1239
Published: Feb. 23, 2024
Supramolecular
polymers
(SPs)
formed
by
strong
directional
noncovalent
interactions
among
molecular
subunits
possess
high
degrees
of
internal
order,
making
them
promising
candidates
for
the
construction
one-dimensional
(1D)
sophisticated
architectures.
However,
packing
subunits,
in
turn,
may
limit
processability
their
overall
shape
and
dimensionality,
which
play
significant
roles
determining
properties
nanomaterials.
How
to
realize
topological
engineering
SPs
beyond
dimensionality
remains
a
challenging
task.
Here,
we
demonstrate
that
1D
crystalline
positively
charged
organometallic
complexes
can
be
tailored
into
multidimensional
loops
adding
oppositely
block
copolymers
(BCPs),
thereby
triggering
dynamic
structural
reconfiguration
preformed
SPs.
The
kinetics
finely
modulated,
enabling
one
rationally
fabricate
heterostructures
containing
both
rigid
flexible
constituent
parts
with
unprecedented
topologies
(i.e.,
tri-block,
penta-block,
hepta-block,
multi-segment,
rod-loop,
etc.),
as
well
spatially
distinct
features.
Biomacromolecules,
Journal Year:
2023,
Volume and Issue:
24(6), P. 2618 - 2632
Published: May 4, 2023
Peptoids
(N-substituted
glycines)
are
a
group
of
highly
controllable
peptidomimetic
polymers.
Amphiphilic
diblock
peptoids
have
been
engineered
to
assemble
crystalline
nanospheres,
nanofibrils,
nanosheets,
and
nanotubes
with
biochemical,
biomedical,
bioengineering
applications.
The
mechanical
properties
peptoid
nanoaggregates
their
relationship
the
emergent
self-assembled
morphologies
relatively
unexplored
critical
for
rational
design
nanomaterials.
In
this
work,
we
consider
family
amphiphilic
consisting
prototypical
tube-former
(Nbrpm6Nc6,
NH2-capped
hydrophobic
block
six
N-((4-bromophenyl)methyl)glycine
residues
conjugated
polar
NH3(CH2)5CO
tail),
sheet-former
(Nbrpe6Nc6,
where
comprises
N-((4-bromophenyl)ethyl)glycine
residues),
an
intermediate
sequence
that
forms
mixed
structures
((NbrpeNbrpm)3Nc6).
We
combine
all-atom
molecular
dynamics
simulations
atomic
force
microscopy
determine
2D
nanosheets
relate
these
observed
morphologies.
find
good
agreement
between
our
computational
predictions
experimental
measurements
Young's
modulus
nanosheets.
A
analysis
bending
along
two
axes
planar
reveals
be
more
favorable
axis
in
which
stack
by
interdigitation
side
chains
compared
they
form
columnar
crystals
π-stacked
chains.
construct
models
Nbrpm6Nc6
tube-forming
predict
stability
optimum
measurements.
theoretical
model
nanotube
suggests
is
free
energy
minimum
corresponding
"Goldilocks"
tube
radius
at
capillary
wave
fluctuations
wall
minimized.
