Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: 88(2)
Published: March 20, 2024
SUMMARYThe genus
Language: Английский
Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(5)
Published: May 1, 2023
Several studies have shown a possible correlation between gut microbiota and COVID-19. However, the cause-and-effect relationship two has not been investigated. We conducted two-sample Mendelian randomization study (MR) using publicly available GWAS data. Inverse variance weighted (IVW) analysis was main MR technique supplemented with other sensitivity analyses. Forty-two bacterial genera were associated COVID-19 susceptibility, hospitalization, severity in IVW method. Among these microbiota, five (genus unknowngenus [id.1000005472], family unknownfamily [id.1000005471], genus Tyzzerella3, order MollicutesRF9.id.11579, phylum Actinobacteria) significantly hospitalization severity. Three (class Negativicutes, Selenomonadales, class while Negativicutes Selenomonadales) severity, susceptibility. Sensitivity did detect any heterogeneity horizontal pleiotropy. Our findings demonstrated that several microorganisms causally linked to COVID-19, improved our understanding of pathology.
Language: Английский
Citations
25
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: May 28, 2024
The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It over 2.47 million deaths through various syndromes such as distress, hypercoagulability, and multiple organ failure. viral invasion proceeds the ACE2 receptor, expressed in cell types, some patients serious damage to tissues, organs, immune cells, microbes that colonize gastrointestinal tract (GIT). Some who survived SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae COVID-19 (PASC). Diagnosis these revealed biological effects, none which are mutually exclusive. However, severity also depends on numerous comorbidities obesity, age, diabetes, hypertension care must be taken with respect other morbidities, host immunity. Gut microbiota relation immunopathology is considered evolve progression via mechanisms biochemical metabolism, exacerbation inflammation, intestinal mucosal secretion, cytokine storm, immunity regulation. Therefore, modulation gut microbiome equilibrium food supplements probiotics remains a hot topic current research debate. In this review, we discuss complications physio-pathological effects infection, GIT response, therapeutic pharmacological strategies. We summarize targets probiotics, their limitations, efficacy preclinical clinical drugs effectively inhibit spread SARS-CoV-2.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250
Published: July 28, 2024
The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications
Language: Английский
Citations
10
International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)
Published: Jan. 9, 2024
Abstract The human oral microbiome harbors one of the most diverse microbial communities in body, playing critical roles and systemic health. Recent technological innovations are propelling characterization manipulation microbiota. High-throughput sequencing enables comprehensive taxonomic functional profiling microbiomes. New long-read platforms improve genome assembly from complex samples. Single-cell genomics provides insights into uncultured taxa. Advanced imaging modalities including fluorescence, mass spectrometry, Raman spectroscopy have enabled visualization spatial organization interactions microbes with increasing resolution. Fluorescence techniques link phylogenetic identity localization. Mass spectrometry reveals metabolic niches activities while generates rapid biomolecular fingerprints for classification. Culturomics facilitates isolation cultivation novel fastidious taxa using high-throughput approaches. Ongoing integration these technologies holds promise transforming our understanding assembly, gene expression, metabolites, microenvironments, virulence mechanisms, microbe-host interfaces context health disease. However, significant knowledge gaps persist regarding community origins, developmental trajectories, homeostasis versus dysbiosis triggers, biomarkers, strategies to deliberately reshape therapeutic benefit. convergence sequencing, imaging, cultureomics, synthetic systems, biomimetic models will provide unprecedented offer opportunities predict, prevent, diagnose, treat associated diseases.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 15, 2024
Chimeric antigen receptor (CAR) -T cell therapy has achieved tremendous efficacy in the treatment of hematologic malignancies and represents a promising regimen for cancer. Despite striking response patients with malignancies, most solid tumors treated CAR-T cells have low rate experience major adverse effects, which indicates need biomarkers that can predict improve clinical outcomes future treatments. Recently, role gut microbiota cancer been established, growing evidence suggested signatures may be harnessed to personally therapeutic or effects optimizing therapy. In this review, we discuss current understanding microbiota, interplay between Above all, highlight potential strategies challenges harnessing as predictor modifier while attenuating toxicity.
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5083 - 5083
Published: May 7, 2024
Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum Porphyromonas (P.) gingivalis, two bacteria that cause periodontitis, are found in OSCC tissues as well premalignant lesions, where they exert pro-tumorigenic activities. Since present also endodontic diseases, playing a role their pathogenesis, here we analyze literature searching for information on impact infection by P. gingivalis or F. could have cellular molecular events involved carcinogenesis. Results from reviewed papers indicate and/or triggers production inflammatory cytokines growth factors dental pulp cells periodontal cells, affecting survival, proliferation, invasion, differentiation cells. addition, induce halt stimulate proliferation invasion stem populating periodontium. Although most confutes possibility bacteria-induced diseases carcinogenesis, analyzed discussed herein recommend further investigations topic.
Language: Английский
Citations
9
Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)
Published: June 3, 2024
Background Microbiomes are essential components of the human body, and their populations substantial. Under normal circumstances, microbiomes coexist harmoniously with but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved occurrence development many gastrointestinal This review focuses on relationship between upper diseases, therapeutic strategies aiming provide valuable insights for clinical prevention treatment.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 16, 2024
The prevalence rate of acute respiratory distress syndrome (ARDS) is estimated at approximately 10% in critically ill patients worldwide, with the mortality ranging from 17% to 39%. Currently, ARDS usually higher COVID-19, giving another challenge for treatment. However, treatment efficacy far satisfactory. relationship between gut microbiota and has been substantiated by relevant scientific studies. not only changes distribution microbiota, but also influences intestinal mucosal barrier through alteration microbiota. modulation can impact onset progression triggering dysfunctions inflammatory response immune cells, oxidative stress, cell apoptosis, autophagy, pyroptosis, ferroptosis mechanisms. Meanwhile, may influence metabolic products In this review, we focus on how further function, cellular functions related signaling pathways during ARDS. roles microbiota-derived metabolites development occurrence are discussed.
Language: Английский
Citations
8
Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 33 - 33
Published: Jan. 17, 2025
A significant proportion of patients who sustain a concussion/mild traumatic brain injury endorse persisting, lingering symptoms. The symptoms associated with concussion are nonspecific, and many other medical conditions present similar Medical that overlap symptomatically include anxiety, depression, insomnia, chronic pain, fatigue, fibromyalgia, cervical strain injuries. One the factors may account for these similarities is all disturbances in optimal functioning autonomic nervous system its intricate interactions endocrine immune system—the three primary regulatory systems body. When clinicians working presenting persisting after concussion, evidence-based treatment options drawn from literature limited. We framework assessment following based on available evidence (treatment trials), neuroanatomical principles (research into physiology concussion), clinical judgment. review research supporting premise behavioral interventions designed to stabilize optimize body have potential reduce improve patients. Foundational rehabilitation strategies areas sleep stabilization, fatigue management, physical exercise, nutrition, relaxation protocols, activation outlined along practical implementing intervention modules
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 709 - 736
Published: Jan. 1, 2025
Language: Английский
Citations
1