Advancing Toxicity Predictions: A Review on in Vitro to in Vivo Extrapolation in Next-Generation Risk Assessment DOI Creative Commons

Peiling Han,

Xuehua Li, Jingyuan Yang

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: 2(7), P. 499 - 513

Published: May 9, 2024

As a key step in next-generation risk assessment (NGRA), vitro to vivo extrapolation (IVIVE) aims mobilize mechanism-based understanding of toxicology translate bioactive chemical concentrations obtained from assays corresponding exposures likely induce bioactivity vivo. This conversion can be achieved via physiologically-based toxicokinetic (PBTK) models and machine learning (ML) algorithms. The last 5 years have witnessed period rapid development IVIVE, with the number IVIVE-related publications increasing annually. Review (1) provide comprehensive overview origin IVIVE initiatives undertaken by multiple national agencies promote its development; (2) compile sort out perform clustering analysis their high-frequency keywords capture research hotspots; (3) comprehensively review PBTK ML model-based studies published understand directions methodology developments; (4) propose future perspectives for two aspects: expanding scope application integrating new technologies. former includes focusing on metabolite toxicity, conducting susceptible populations, advancing ML-based quantitative models, extending ecological effects. latter combining systems biology, multiomics, adverse outcome networks aiming at more microscopic, mechanistic, toxicity prediction. highlights important value NGRA, goal providing confidence routine use prioritization, hazard assessment, regulatory decision making.

Language: Английский

Multifunctional Manganese–Nucleotide Laccase-Mimicking Nanozyme for Degradation of Organic Pollutants and Visual Assay of Epinephrine via Smartphone DOI

Qiaorong Tang,

Caihong Zhou,

Lu Shi

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(11), P. 4736 - 4744

Published: March 11, 2024

As a natural green catalyst, laccase has extensive application in the fields of environmental monitoring and pollutant degradation. However, susceptibility to influences poor reusability seriously hinder its application. To address these concerns, for first time, manganese ion replaced copper as active center coordinate with guanosine monophosphate (GMP) synthesizing mimic high catalytic activity. Compared laccase, laccase-like nanozyme (Mn–GMPNS) demonstrated superior thermal stability, acid–base resistance, salt tolerance, reusability, substrate universality. Benefiting from activity Mn–GMPNS, epinephrine, significant neurotransmitter hormone associated numerous diseases, was visually detected within 10 min portable assay by smartphone. More encouragingly, Mn–GMPNS can efficiently degrade dye pollutants, achieving decolorization rate over 70% 30 min. Thus, coordination between nucleotide potential rational design nanozymes activity, low cost, good biocompatibility.

Language: Английский

Citations

27
High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage DOI Creative Commons
Yunjia Lai, Jeremy P. Koelmel, Douglas G. Walker

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 12784 - 12822

Published: July 10, 2024

In the modern "omics" era, measurement of human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics metabolomics, has emerged as leading technology to broadly profile chemical exposure agents related biomolecules for accurate measurement, high sensitivity, rapid data acquisition, increased resolution space. Non-targeted approaches are increasingly accessible, supporting shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical computational infrastructures needed expand analysis coverage through streamlined, scalable, harmonized workflows pipelines that permit longitudinal tracking, retrospective validation, multi-omics integration meaningful health-oriented inferences. this article, we survey literature on state-of-the-art technologies, review current informatic pipelines, provide an up-to-date reference exposomic chemists, toxicologists, epidemiologists, care providers, stakeholders health sciences medicine. We propose efforts benchmark fit-for-purpose platforms expanding space, including gas/liquid chromatography-HRMS (GC-HRMS LC-HRMS), discuss opportunities, challenges, strategies advance burgeoning field exposome.

Language: Английский

Citations

22
Lignin-based support for metal catalysts: Synthetic strategies, performance boost, and application advances DOI

Tairan Pang,

Guanhua Wang,

Wenjie Sui

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216426 - 216426

Published: Jan. 10, 2025

Language: Английский

Citations

13
Integrating photocatalytic hydrogen evolution with antibiotic degradation over a dual Z-scheme heterojunction DOI

Churu Zhang,

Shuai Hu, Weigang Cui

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160317 - 160317

Published: Feb. 1, 2025

Language: Английский

Citations

4
Trophic transfer and interfacial impacts of micro(nano)plastics and per-and polyfluoroalkyl substances in the environment DOI
Muhammad Junaid, Shulin Liu, Qiang Yue

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133243 - 133243

Published: Dec. 13, 2023

Language: Английский

Citations

26
Recent advances of mass spectrometry-based analytical methods for endocrine disrupting chemicals in human matrices DOI

Mengjie Yue,

Xiaolu Zhou,

Jiatong Fan

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 171, P. 117523 - 117523

Published: Jan. 5, 2024

Language: Английский

Citations

16
Environmental factors in public health: A review of global challenges and solutions DOI Creative Commons

Tolulope O Olorunsogo,

Jane Osareme Ogugua,

Muridzo Muonde

et al.

World Journal of Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 21(1), P. 1453 - 1466

Published: Jan. 20, 2024

Environmental factors play a pivotal role in shaping public health outcomes on global scale. This paper provides succinct overview of the review exploring intricate relationship between environmental elements and health, highlighting challenges faced worldwide proposing solutions for healthier future. The begins by dissecting diverse range that significantly impact health. From air water pollution to climate change, scope encompasses both traditional pollutants emerging threats. interconnectedness ecosystems human is underscored, emphasizing need comprehensive understanding determinants. Amidst challenges, navigates through innovative strategies mitigate adverse effects factors. Initiatives addressing reduction, sustainable urban planning, ecosystem preservation emerge as key components. exploration extends incorporation advanced technologies, data-driven interventions, international collaborations tackle issues at level. Furthermore, delves into importance awareness education fostering practices. Empowering communities understand reciprocal their environment identified crucial aspect long-term solutions. policymakers advocacy promoting policies prioritize also emphasized. encapsulates web posed envisions future where proactive measures collaborative efforts lead harmonious coexistence populations surroundings. proposed aim inspire paradigm shift towards practices, ensuring resilient community.

Language: Английский

Citations

14
One‐Step Electrochemical Synthesis of Multiyolk–Shell Nanocoils for Exceptional Photocatalytic Performance DOI
Jun Hwan Moon, Eunsoo Oh, Thomas Myeongseok Koo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 8, 2024

Multiyolk-shell (mYS) nanostructures have garnered significant interest in various photocatalysis applications such as water splitting and waste treatment. Nonetheless, the complexity rigorous conditions for synthesis hindered their widespread implementation. This study presents a one-step electrochemical strategy synthesizing multiyolk-shell nanocoils (mYSNC), wherein multiple cores of noble metal nanoparticles, Au, are embedded within hollow coil-shaped FePO

Language: Английский

Citations

13
Fragmentation Pattern-Based Screening Strategy Combining Diagnostic Ion and Neutral Loss Uncovered Novel para-Phenylenediamine Quinone Contaminants in the Environment DOI Creative Commons
Wei Wang, Guodong Cao, Jing Zhang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(13), P. 5921 - 5931

Published: March 21, 2024

Identifying transformed emerging contaminants in complex environmental compartments is a challenging but meaningful task. Substituted para-phenylenediamine quinones (PPD-quinones) are originating from rubber antioxidants and have been proven to be toxic the aquatic species, especially salmonids. The emergence of multiple PPD-quinones various matrices evidence their specific hazards underscore need understand occurrences. Here, we introduce fragmentation pattern-based nontargeted screening strategy combining full MS/All ion fragmentation/neutral loss-ddMS2 scans identify potential unknown different matrices. Using diagnostic fragments m/z 170.0600, 139.0502, characteristic neutral losses 199.0633, 138.0429 Da, six known three novel were recognized air particulates, surface soil, tire tissue. Their structures confirmed, concentration composition profiles clarified with self-synthesized standards. N-(1-methylheptyl)-N′-phenyl-1,4-benzenediamine quinone (8PPD-Q) N,N′-di(1,3-dimethylbutyl)-p-phenylenediamine (66PD-Q) identified quantified for first time, median concentrations found 0.02–0.21 μg·g–1 tissue, 0.40–2.76 pg·m–3 particles, 0.23–1.02 ng·g–1 soil. This work provides new presence environment, showcasing environment.

Language: Английский

Citations

11
Triggering nanoconfinement effect in advanced oxidation processes (AOPs) for boosted degradation of organic contaminants: A review DOI
Junsuo Li,

Yongshuo Wang,

Ziqian Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158428 - 158428

Published: Dec. 9, 2024

Language: Английский

Citations

11