Copper-catalyzed highly switchable defluoroborylation and hydrodefluorination of 1-(trifluoromethyl)alkynes DOI Creative Commons
Jun Xu,

Zhao-Cheng Yan,

Li Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 17, 2024

CF2-containing compounds hold significant potential in drug discovery, organic synthesis, and materials science. However, synthesizing various building blocks from a single compound remains challenging. Here, we present Cu-catalyzed, switchable defluoroborylation hydrodefluorination of trifluoromethylated alkynes, yielding four types compounds. The chemo- regio-selective sp2/sp3 1,2-diborylation sp2 monoborylation 1-(trifluoromethyl)alkynes are controlled by adjusting the solvent ligand quantity. Additionally, altering base allows selective generation gem-difluoroalkenes or difluoromethylalkenes. Notably, our method prevents over-defluorination CF3 group on unsaturated C-C bonds during nucleophilic additions, preserving pharmaceutically valuable CF2 group. Experimental data density functional theory (DFT) calculations elucidate regioselectivities Cu-Bpin addition regulatory role deborylation processes. Achieving modular synthesis formidable challenge. Herein, authors Cu-catalyzed affording synthetically challenging

Language: Английский

Polymer-Based Drug Delivery Systems for Cancer Therapeutics DOI Open Access
Ling Ding, Prachi Agrawal, Sandeep Kumar Singh

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(6), P. 843 - 843

Published: March 19, 2024

Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, off-target effects of chemotherapy known to produce side and dose-limiting toxicities. Novel delivery platforms based on natural synthetic polymers enhanced pharmacokinetic potential treatment cancer have grown tremendously over past 10 years. Polymers can facilitate selective targeting, enhance prolong circulation, improve delivery, provide controlled release cargos through various mechanisms, including physical adsorption, chemical conjugation, internal loading. Notably, that biodegradable, biocompatible, physicochemically stable considered be ideal carriers. This biomimetic bio-inspired system offers a bright future effective drug overcome obstacles encountered. review focuses barriers impact success as well recent developments improving

Language: Английский

Citations

26
Understanding the Selective Removal of Perfluoroalkyl and Polyfluoroalkyl Substances via Fluorine–Fluorine Interactions: A Critical Review DOI
Kaixing Fu,

Jinjing Huang,

Fang Luo

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

As regulatory standards for per- and polyfluoroalkyl substances (PFAS) become increasingly stringent, innovative water treatment technologies are urgently demanded effective PFAS removal. Reported sorbents often exhibit limited affinity frequently hindered by competitive background substances. Recently, fluorinated (abbreviated as fluorosorbents) have emerged a potent solution leveraging fluorine-fluorine (F···F) interactions to enhance selectivity efficiency in This review delves into the designs applications of fluorosorbents, emphasizing how F···F improve binding affinity. Specifically, existence results removal efficiencies orders magnitude higher than other counterpart sorbents, particularly under conditions. Furthermore, we provide detailed analysis fundamental principles underlying elucidate their synergistic effects with sorption forces, which contribute enhanced efficacy selectivity. Subsequently, examine various fluorosorbents synthesis fluorination techniques, underscore importance accurately characterizing through advanced analytical methods, emphasize significance this interaction developing selective sorbents. Finally, discuss challenges opportunities associated employing techniques guide design advocate further research development sustainable cost-effective interactions.

Language: Английский

Citations

14
Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives DOI
Jiyuan Liu, Fan Yang, Jinqu Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

Citations

12
2D and 3D Self‐Assembly of Fluorine‐Free Pillar‐[5]‐Arenes and Perfluorinated Diacids at All‐Aqueous Interfaces DOI
Lawrence W. Honaker, Tu‐Nan Gao, Kelsey Rianne de Graaf

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: May 24, 2024

Abstract The interaction of perfluorinated molecules, also known as “forever chemicals” due to their pervasiveness, with environment remains an important yet poorly understood topic. In this work, the self‐assembly molecules multivalent hosts, pillar‐[5]‐arenes, is investigated. It found that perfluoroalkyl diacids and pillar‐[5]‐arenes rapidly strongly complex each other at aqueous interfaces, forming solid interfacially templated films. Their complexation shown be driven primarily by fluorophilic aggregation assisted electrostatic interactions, supported crystal structure complexes, leads formation quasi‐2D phase‐separated This process can further manipulated using two‐phase system microdroplets, enabling controlled 3D micro‐scaffolds.

Language: Английский

Citations

9
Controlled Radical Copolymerization toward Tailored F/N Hybrid Polymers by Using Light‐Driven Organocatalysis DOI
Yufei Chen, Shantao Han,

Kaixuan Chen

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)

Published: June 24, 2024

Controlled radical copolymerizations present attractive avenues to obtain polymers with complicated compositions and sequences. In this work, we report the development of a visible-light-driven organocatalyzed controlled copolymerization fluoroalkenes acyclic N-vinylamides for first time. The approach enables on-demand synthesis broad scope amide-functionalized main-chain fluoropolymers via novel fluorinated thiocarbamates, facilitating regulations over chemical alternating fractions by rationally selecting comonomer pairs ratios. This method allows temporally chain-growth external light, maintains high chain-end fidelity that promotes facile preparation block Notably, obtained F/N hybrid polymers, upon hydrolysis, afford free amino-substituted versatile post modifications toward various functionalities (e.g., amide, sulfonamide, carbamide, thiocarbamide). We further demonstrate in situ formation polymer networks desirable properties as protective layers on lithium metal anodes, presenting promising avenue advancing batteries.

Language: Английский

Citations

4
Continuous and selective recovery of fluorobenzene from complex water emulsion by superhydrophobic wood mimetic cryogel DOI
Xinqi Wang, Jiani Xu, Xiaoli Huang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159710 - 159710

Published: Jan. 1, 2025

Language: Английский

Citations

0
Synthesis of Degradable Mainchain Semifluorinated Polyester by CuAAC with Reaction‐Enhanced Reactivity of Intermediate (RERI) Mechanism DOI

Jiasheng Wu,

Zheqi Li,

Zhuo Zhou

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Quantitative insertion of functionality into polymer chains via step-growth polymerization is challenging due to the random bimolecular reaction and relatively low extent reaction. Herein, a copper-catalyzed azide-alkyne cycloaddition (CuAAC) with reaction-enhanced reactivity intermediates (RERI) mechanism applied for precise degradable functions mainchain semifluorinated endowed it controlled degradability. In this CuAAC polymerization, bis-alkynyl-terminated (A2) monomer can be quantitatively consumed when slightly excess 2,2-bis(azidomethyl)propane-1,3-diyl bis(2-methylpropanoate) (BiAz, B2) RERI effect employed. The copolymerization o-nitrobenzyl ester-derived A2 (A2-ONB), fluorinated (A2-F), B2 monomers produced copolymers tunable chemical composition high molecular weight, along quantitative [A2-ONB] units. These are capable degradation profile under ultraviolet radiation undergo complete basic condition. This work provided simple approach preparing polymers

Language: Английский

Citations

0
FluoBase: a fluorinated agents database DOI Creative Commons

Rafal Mulka,

Dan Su,

Wen-Shuo Huang

et al.

Journal of Cheminformatics, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 11, 2025

Organofluorine compounds, owing to their unique physicochemical properties, play an increasingly crucial role in fields such as medicine, pesticides, and advanced materials. Fluorinated reagents are indispensable for developing efficient synthetic methods organofluorine compounds serve the cornerstone of chemistry. Equally important fluorinated functional molecules, which contribute specific properties necessary applications pharmaceuticals, agrochemicals, materials science. However, information about these agents' structure, functions is scattered throughout vast literature, making it inconvenient chemists access utilize them effectively. Recognizing need a dedicated organized resource, we present FluoBase—a comprehensive agents database designed streamline key agents. FluoBase aims become premier resource related fluorine chemistry, serving scientific community anyone interested chemistry machine learning property predictions. freely available at https://fluobase.siochemdb.com . Scientific contribution provide on structures, molecules.

Language: Английский

Citations

0
Large-Area Deposition of Hydrophobic Poly(hexafluorobutyl Acrylate) Thin Films on Wetting-Sensitive and Flexible Substrates via Plasma-Enhanced Chemical Vapor Deposition DOI Open Access
Kurtuluş Yılmaz, Mehmet Gürsoy, Mustafa Karaman

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(6), P. 791 - 791

Published: March 17, 2025

In this study, hydrophobic poly(hexafluorobutyl acrylate) (PHFBA) thin films were successfully deposited over a large area of 25 × 50 cm using plasma-enhanced chemical vapor deposition (PECVD). Key parameters, including plasma power and the distance between antenna substrate, optimized to achieve highest rate while ensuring uniformity defect-free coatings. The optimal conditions determined as 5 W 9 antenna–substrate distance, yielding maximum 11.3 nm/min. PHFBA’s low fluorine content makes it more environmentally biologically friendly alternative compared heavily fluorinated polymers, addressing concerns about toxicity environmental impact. coatings applied flexible wetting-sensitive paper towel which was coated without any visible defects. contact angle measurements confirmed nature films, with water 131.9° after PHFBA. This study highlights potential PECVD an efficient scalable method for producing coatings, combining high-performance properties improved considerations. results not only validate precise film fabrication but also open new possibilities its use in applications requiring durable functional surface modifications.

Language: Английский

Citations

0
Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications DOI
Shuai Liu, Jun Zhou, Lu Yu

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, material sciences. Although fluorine-nitrogen chemistry has long rich history, this field received increasing interest made remarkable progress over the past two decades, driven by recent advancements transition metal organocatalysis photochemistry. This review, emphasizing contributions from 2015 to 2023, aims update state of art synthesis applications nitrogen-based organofluorine functional molecules chemistry. In dedicated sections, we first focus on fluorine-containing reagents organized according type groups attached nitrogen, including N-F, N-RF, N-SRF, N-ORF. review also covers nitrogen-linked building blocks, catalysts, pharmaceuticals, agrochemicals, underlining these components' broad applicability growing importance modern

Language: Английский

Citations

0