Mechanoadaptive Bioelectronics for Deep Tissue Sensing DOI Open Access
Xueyang Ren,

Yuehui Yuan,

Jianqing Li

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Comprehensive Summary Deep‐tissue physiological signals are critical for accurate disease diagnosis. Current clinical equipment, however, often falls short of enabling continuous, long‐term monitoring. Wearable and implantable flexible electronics offer a promising avenue addressing this limitation, allowing in vivo signal collection paving the way early diagnosis personalized treatment. A major challenge lies ensuring that these devices seamlessly integrate with diverse microenvironments throughout human body. Mechanoadaptive bioelectronics is emerging as key solution to optimize acquisition device robustness. This review provides comprehensive overview characteristics various organs types they generate. Furthermore, it explores recent advancements mechanoadaptive bioelectronics, systematically categorizes their strategies, underscores potential revolutionize healthcare. Finally, we delve into ongoing challenges field highlight directions advance adaptability further. Key Scientists In 2017, researchers developed an ionic skin enhanced mechanical compatibility through strain‐hardening properties. [1] Three years later, neural interface platform called adaptive self‐healing electronic epineurium (A‐SEE) was reported. [2] minimized stress on tissue by dynamically relaxing stress. 2021, hydrogel hybrid probe tracking isolated neuroelectric activity, optogenetics, behavioral studies circuits. also utilized hydration‐induced softening minimize foreign body response. [3] same year, shape‐adaptive imager Kirigami design proposed. [4] following morphing (MorphE) reported, which exhibited attractive viscoelasticity minimal growing nerve during implantation. [5] 2023, standardized tissue‐electronic developed, can be implanted minimally invasive cardiac procedures rapidly beating heart. [6] Recently, needle‐like microfiber based biphasic liquid metal created. reach target site simply puncturing enable multifunctional sensing. [7] At about time, amalgamated living synthetic components studying treating inflammatory disease. [8] enables real‐time digital updates potentially treatment non‐resolving inflammation, enlightening new generation bioelectronics.

Language: Английский

Breaking the Saturation of Sensitivity for Ultrawide Range Flexible Pressure Sensors by Soft‐Strain Effect DOI
Yue Li, Weijie Zhang, Cheng Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract The flexible pressure sensors with a broad range and unsaturated sensitivity are highly desired in practical applications. However, by piezoresistive effect always limited the compressibility of sensing layers, resulting theoretically decreasing less than 100%. Here, unique strategy is proposed that utilizes strain effect, simultaneously achieving trade‐off between wider detection sensitivity. Ascribed to layers induced interlaced microdomes, possess an increased (5.22–70 MPa −1 ) over ultrawide (45 Pa–4.1 MPa), high‐pressure resolution (5 Pa), fast response/recovery time (30/45 ms), robust response under loading 3.5 for more 5000 cycles. These superior performances allow sensor monitor large pressure. array can assist doctors restoring neutral mechanical axis, tracking knee flexion angles, extracting gait features. Moreover, be integrated into joint motion surveillance system map balance medial–lateral contact forces on metal compartments real time, demonstrating potential further development precise medical human–machine interfaces during total replacement surgery.

Language: Английский

Citations

24

Advances in bio-integrated wearable and implantable optoelectronic devices for cardiac healthcare DOI Creative Commons
Cheng Li,

Yangshuang Bian,

Zhiyuan Zhao

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous comfortable for patients. Recently, wearable implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological in an imperceptible spatiotemporally unconstrained manner, opening countless possibilities intelligent healthcare paradigm. To achieve biointegrated cardiac healthcare, researchers have focused on novel strategies construction flexible/stretchable systems. Here, we overview progress flexible stretchable optoelectronics devices. Firstly, device design addressed, including mechanical design, interface adhesion, encapsulation strategies. Next, practical applications monitoring, optogenetics, nongenetic stimulation are presented. Finally, outlook systems discussed.

Language: Английский

Citations

17

From lab to wearables: Innovations in multifunctional hydrogel chemistry for next-generation bioelectronic devices DOI

Hin Kiu Lee,

Ye Ji Yang,

Gyan Raj Koirala

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 310, P. 122632 - 122632

Published: May 28, 2024

Language: Английский

Citations

14

Nanomaterials for Flexible Neuromorphics DOI

Guanglong Ding,

Hang Li,

Jiyu Zhao

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(22), P. 12738 - 12843

Published: Nov. 5, 2024

The quest to imbue machines with intelligence akin that of humans, through the development adaptable neuromorphic devices and creation artificial neural systems, has long stood as a pivotal goal in both scientific inquiry industrial advancement. Recent advancements flexible electronics primarily rely on nanomaterials polymers owing their inherent uniformity, superior mechanical electrical capabilities, versatile functionalities. However, this field is still its nascent stage, necessitating continuous efforts materials innovation device/system design. Therefore, it imperative conduct an extensive comprehensive analysis summarize current progress. This review highlights applications neuromorphics, involving inorganic (zero-/one-/two-dimensional, heterostructure), carbon-based such carbon nanotubes (CNTs) graphene, polymers. Additionally, comparison summary structural compositions, design strategies, key performance, significant these are provided. Furthermore, challenges future directions pertaining materials/devices/systems associated neuromorphics also addressed. aim shed light rapidly growing attract experts from diverse disciplines (e.g., electronics, science, neurobiology), foster further for accelerated development.

Language: Английский

Citations

12

Synergistic Structural Construction of Strain Sensors with Low Baseline Drift and High Sensitivity for Continuous Dynamic Monitoring DOI

Tingkang Yuan,

Ruilin Yin,

Chengwei Li

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Strain sensors based on conductive elastomers face challenges like baseline drift and noise due to inherent viscoelasticity weak electrode interfaces under dynamic strains. Herein, a synergistic structure with biphasic hierarchical networks stable is proposed address these issues. The sensor employs multilayer polydimethylsiloxane (PDMS) substrate, carbon nanotube-doped PDMS (CNT-PDMS), Ag film. Electrodes are fixed using rigid island reinforced mortise tenon joint formed CNT-PDMS. film dominates resistance during release, significantly reducing drift. Strain-insensitive further reduce noise. This optimized design ensures 99.999% recovery without delay, even at high-speed (800 mm/min) large (80%) exhibits high gauge factor of 55442, low detection limit (0.02%), excellent stability (5000 cycles). With the designed algorithms, single-channel achieves 98.2% decoding accuracy for various gestures, demonstrating great potential wearable electronics.

Language: Английский

Citations

1

A mechanically Robust, Damping, and High‐Temperature Tolerant Ion‐Conductive Elastomer for Noise‐Free Flexible Electronics DOI

Shengtao Shen,

Zehang Du,

Piaopiao Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(46)

Published: July 18, 2024

Abstract Ion‐conductive elastomers capable of damping can significantly mitigate the interference caused by mechanical noise during data acquisition in wearable and biomedical devices. However, currently available often lack robust properties have a narrow temperature range for effective damping. Here, precise modulation weak to strong ion‐dipole interactions plays crucial role bolstering network stability tuning relaxation behavior supramolecular ion‐conductive (SICEs). The SICEs exhibit impressive properties, including modulus 13.2 MPa, toughness 65.6 MJ m −3 , fracture energy 74.9 kJ −2 . Additionally, they demonstrate remarkable capabilities, with capacity 91.2% peak tan δ 1.11. Furthermore, entropy‐driven rearrangement ensures SICE remain stable even at elevated temperatures (18–200 °C, > 0.3), making it most thermally resistant elastomer reported date. Moreover, proves filtering out various noises physiological signal detection strain sensing, highlighting its vast potential flexible electronics.

Language: Английский

Citations

6

Functional Hydrogels for Wearable Electronics DOI

Adnan Zameer,

Yanxia Qin, Hongmei Xu

et al.

Macromolecular Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Functional‐hydrogel‐based wearable sensors are a rapidly evolving field in the modern era due to their various attractive features. Functional hydrogels have great ability for multiple applications because of unusual combination biocompatibility, flexibility, and responsiveness different stimuli. Wearable electronics illustrate next‐generation technology, seamlessly incorporating sophisticated features into everyday accessories provide continuous health monitoring, real‐time data collecting, improved human–computer interactions. This review provides an extensive summary state functional electronics. The basic ideas behind first introduced, emphasizing how they work together harmoniously. types synthesis methods hydrogels, including chemical physical cross‐linking methods, highlighted. A comprehensive investigation is carried out intrinsic properties conductivity, mechanical strength, stimuli‐responsiveness. Subsequently, explored electronics, motion sensors, electrophysiological respiratory gas body fluid biomarker wound healing monitoring. Recent developments valuable used show these materials can revolutionize design technology. researchers traversing interdisciplinary fields polymer, bioelectronics, chemistry.

Language: Английский

Citations

0

Engineered Living Energy Materials DOI Creative Commons
Xinyi Yuan, Haiyi Xu, Xingwu Liu

et al.

Interdisciplinary materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

ABSTRACT To foster sustainable development, a pivotal trend lies in harnessing energy supplies that propel modern economic and societal progress. Recent advancements living materials for applications have sparked groundbreaking research area: engineered (ELEMs), which seamlessly integrate biological artificial systems efficient conversion storage. consolidate this area, herein, we summarize delve into the evolution of ELEMs. Firstly, provide an overview structural features mechanisms employed by bio‐modules spanning proteins, organelles, entire organisms. They can be directly used as components constructing ELEMs or inspirations design such entities. Then, comprehensively review latest strides based on their distinct modes. Finally, discuss challenges confronting envision future trajectories. The progress holds immense potential to catalyze interdisciplinary endeavors encompassing medicine, environmental science, technologies.

Language: Английский

Citations

0

Ear‐Area Soft Electronics for Advanced Healthcare Monitoring DOI
Yue Yu, Haoyu Zhang, Xiaosen Pan

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Abstract The ear harbors a wealth of critical physiological and pathological information, positioning it as an ideal site for healthcare monitoring. However, the intricate geometry sensitivity pose formidable technical hurdles to effective Soft electronics, renowned their mechanical deformability, excellent skin conformability, biocompatibility, offer compelling advantages, particularly within emerging contexts fifth‐generation technology Internet Things. These innovations provide essential support achieving comprehensive monitoring via ear‐area soft electronics. This review comprehensively outlines recent advancements in electronics advanced authors begin by elucidating properties external, middle, inner from clinical perspectives. Subsequently, leveraging these anatomical insights, state‐of‐the‐art bioelectric, biophysical, biochemical, multimodal are explored. Furthermore, insights offered into enduring challenges prospective directions systematic sensor design, data processing methodologies, translational applications. As whole, will new paradigms shift evolution wearable implantable thereby fostering rapid high‐quality development systems.

Language: Английский

Citations

0

Smart Bioelectronics for Real-Time Diagnosis and Therapy of Body Organ Functions DOI
Lili Guo,

Hin Kiu Lee,

Suyoun Oh

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Noncommunicable diseases (NCDs) associated with cardiovascular, neurological, and gastrointestinal disorders remain a leading cause of global mortality, sounding the alarm for urgent need better diagnostic therapeutic solutions. Wearable implantable biointegrated electronics offer groundbreaking solution, combining real-time, high-resolution monitoring innovative treatment capabilities tailored to specific organ functions. In this comprehensive review, we focus on affecting brain, heart, organs, bladder, adrenal gland, along their physiological parameters. Additionally, provide an overview characteristics these parameters explore potential bioelectronic devices in situ sensing applications highlight recent advancements deployment across organs. Finally, analyze current challenges prospects implementing closed-loop feedback control systems integrated sensor-therapy applications. By emphasizing organ-specific advocating systems, review highlights future bioelectronics address needs serves as guide researchers navigating interdisciplinary fields diagnostics, therapeutics, personalized medicine.

Language: Английский

Citations

0