Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Functional
biomaterials
composed
of
multiple
biomacromolecules
have
significant
advantages
over
those
made
from
a
single
type.
However,
harmoniously
integrating
various
remains
challenging.
Neutrophil
extracellular
traps
(NETs),
an
emerging
biological
structure
released
neutrophils,
serve
as
natural
prototype
worth
investigating
and
learning
from.
NETs
consist
intricate
exhibit
web‐like
microstructure,
endowing
them
with
multifaceted
roles
in
both
physiological
pathological
processes.
In
this
review,
research
progress
is
systematically
examined
on
materials
science
perspective.
First,
the
origin
transformation
are
introduced,
their
functional
mechanisms
NET
components
thoroughly
dissected
rather
than
conventionally
treating
entity.
Second,
given
complex
functions,
revealed
potential
biomarker
for
disease
prediction.
Third,
typical
characterization
technologies
analysis
summarized.
Fourth,
artificial
inspired
by
discussed.
addition,
regulatory
processes
provide
bio‐inspired
prototypes
design
advanced
materials.
Finally,
perspectives
opportunities
challenges
advancing
presented
biomarkers
models
development
Advanced Electronic Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Abstract
Microfluidic‐based
wearable
electrochemical
sensors
represent
a
transformative
approach
to
non‐invasive,
real‐time
health
monitoring
through
continuous
biochemical
analysis
of
body
fluids
such
as
sweat,
saliva,
and
interstitial
fluid.
These
systems
offer
significant
potential
for
personalized
healthcare
disease
management
by
enabling
detection
key
biomarkers.
However,
challenges
remain
in
optimizing
microfluidic
channel
design,
ensuring
consistent
biofluid
collection,
balancing
high‐resolution
fabrication
with
scalability,
integrating
flexible
biocompatible
materials,
establishing
standardized
validation
protocols.
This
review
explores
advancements
techniques,
integrated
that
have
improved
sensitivity,
selectivity,
durability.
Conventional
photolithography,
3D
printing,
laser‐based
methods
are
compared,
highlighting
their
mechanisms,
advantages,
trade‐offs
production.
The
application
section
summarizes
strategies
overcome
variability
composition,
sensor
drift,
user
adaptability
innovative
solutions
hybrid
material
integration,
self‐powered
systems,
AI‐assisted
data
analysis.
By
analyzing
recent
breakthroughs,
this
paper
outlines
critical
pathways
expanding
technologies
achieving
seamless
operation
diverse
real‐world
settings,
paving
the
way
new
era
digital
health.
Accurate,
precise
detection
of
Salmonella
typhimurium
(Salmonella)
is
crucial
for
maintaining
water
safety
and
preventing
outbreaks
foodborne
diseases.
Bacterial
culture,
the
gold
standard
detection,
time-consuming
cumbersome.
Herein,
a
novel
ratiometric
electrochemical
biosensing
platform
was
constructed
based
on
combining
signals
DNAzyme
metal-organic
framework
(MOF)
programmed
DNA
assembly
amplification
by
target-specific
cleavage
catalyzed
hairpin
(CHA).
used
to
identify
detect
S.
(ST)
due
its
release
RNase
H2
(STH2)
which
specifically
cleaves
rA
site
in
DNAzyme,
causing
subsequent
reaction.
To
achieve
proportional
dual
signaling
strategy,
tag,
ferrocene
(Fc),
modified
onto
sequence
H1,
Fe-MOF,
an
indicator
with
high
redox
potential
separation,
selected
as
probe.
The
prepared
biosensor
analyzed
via
alternating
current
voltammetry
(ACV).
urban
source
samples
using
yielded
essentially
same
results
commercial
test
strips,
even
higher
sensitivity,
confirming
accuracy
usefulness
this
sensing
strategy.
This
study
describes
valuable
highly
specific,
ultrasensitive
aqueous
environments.
Chinese Journal of Chromatography,
Journal Year:
2025,
Volume and Issue:
43(4), P. 297 - 308
Published: April 1, 2025
Aptamers
obtained
through
systematic
evolution
of
ligands
by
exponential
enrichment
(SELEX)
techniques
are
single
stranded
deoxyribonucleic
acid
(ssDNA)
or
RNA
molecules
capable
specifically
recognizing
target
molecules.
Such
aptamers
easily
chemically
synthesized
and
modified,
highly
thermally
stable,
low
toxicity
immunogenicity.
that
small
have
broad
applications
prospects
for
the
development
new
drugs,
treating
tumors,
diagnosing
diseases,
monitoring
environmental
pollution,
detecting
in
ultrafast
sensitive
detection
applications.
However,
simple
structures
molecular
masses
molecules,
along
with
limited
number
binding
groups
available
interacting
nucleic
acids
lead
to
unstable
aptamer-small
molecule
binding,
which
poses
significant
challenges
aptamer
screening
sensor
development.
Efficient
crucial
identifying
excellent
performance
characteristics.
At
present,
suitable
small-molecule
targets
mainly
divided
into
three
categories:
target-immobilized-based
technique,
library-immobilized-based
target-non-immobilized
technique.
Among
them,
technique
require
fewer
rounds
result
superior
(typically
nmol/L
level)
affinities.
This
paper
summarized
non-immobilized
targets,
including
principle,
advantages,
disadvantages
application
progress
associated
graphene
oxide
(GO)-SELEX,
capillary
electrophoresis
(CE)-SELEX,
gold
nanoparticle-assisted
(GNP)-SELEX
techniques.
In
addition,
strategies
selecting
control
aptamer-specific
evaluation
were
summarized.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Functional
biomaterials
composed
of
multiple
biomacromolecules
have
significant
advantages
over
those
made
from
a
single
type.
However,
harmoniously
integrating
various
remains
challenging.
Neutrophil
extracellular
traps
(NETs),
an
emerging
biological
structure
released
neutrophils,
serve
as
natural
prototype
worth
investigating
and
learning
from.
NETs
consist
intricate
exhibit
web‐like
microstructure,
endowing
them
with
multifaceted
roles
in
both
physiological
pathological
processes.
In
this
review,
research
progress
is
systematically
examined
on
materials
science
perspective.
First,
the
origin
transformation
are
introduced,
their
functional
mechanisms
NET
components
thoroughly
dissected
rather
than
conventionally
treating
entity.
Second,
given
complex
functions,
revealed
potential
biomarker
for
disease
prediction.
Third,
typical
characterization
technologies
analysis
summarized.
Fourth,
artificial
inspired
by
discussed.
addition,
regulatory
processes
provide
bio‐inspired
prototypes
design
advanced
materials.
Finally,
perspectives
opportunities
challenges
advancing
presented
biomarkers
models
development
