Activatable Near-Infrared Fluorescence Probe for Hypochlorous Acid Detection in Early Diagnosis of Keloids

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(42), P. 16964 - 16970

Published: Oct. 8, 2024

Keloids represent pathologic conditions characterized by the presence of hyalinized collagen bundles and chronic inflammatory reactions. Recently, increased ROS production disrupted apoptosis mechanisms in keloids have been reported, although detailed remain unclear. Herein, we developed a specific fluorescence probe,

Language: Английский

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Advanced Applications of Nanomaterials in Atherosclerosis Diagnosis and Treatment: Challenges and Future Prospects

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58072 - 58099

Published: Oct. 21, 2024

Atherosclerosis-induced coronary artery disease is a major cause of cardiovascular mortality. Clinically, conservative treatment strategies for atherosclerosis still focus on lifestyle interventions and the use lipid-lowering anticoagulant medications. Despite achieving some therapeutic effects, these approaches are limited by low bioavailability, long intervention periods, significant side effects. With advancement nanotechnology, nanomaterials have demonstrated extraordinary potential in biomedical field. Their excellent biocompatibility, surface modifiability, high targeting capability not only enable efficient diagnosis plaque progression but also allow precise drug delivery within atherosclerotic plaques, significantly enhancing bioavailability reducing systemic Here, we systematically review current research progress field to summarize types their applications both atherosclerosis. Notably, context therapy, provide comprehensive overview nanomaterial based targeted systems different cell plaques. Additionally, address persistent challenge clinical translation summarizing issues providing directions innovation improvement design. Overall, believe that this summarizes challenges thereby offering insights references development materials

Language: Английский

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Frontiers in Fluorescence imaging: Tools for the In-Situ Sensing of Disease Biomarkers

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

A comprehensive overview of recent advancements in fluorescence imaging techniques for situ sensing various biomarkers, emphasizing the transformative potential artificial intelligence shaping future bioimaging.

Language: Английский

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Recent Advances in Indocyanine Green-Based Probes for NIR-II Fluorescence Imaging and Therapy

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred as shortwave infrared, has received substantial attention because of its markedly reduced autofluorescence, deeper tissue penetration, and enhanced spatiotemporal resolution compared traditional (NIR) imaging. Indocyanine green (ICG), US Food Drug Administration-approved NIR fluorophore, long been used in applications, including blood vessel angiography, vascular perfusion monitoring, tumor detection. Recent advancements NIR-II technology have revitalized interest ICG, revealing extended tail fluorescence beyond nm reaffirming potential clinically translatable fluorophore for vivo theranostic applications diagnosing various diseases. This review emphasizes notable advances use ICG derivatives image-guided therapy from both fundamental perspectives. We provide concise conclusion discuss challenges future opportunities with using approved fluorophores.

Language: Английский

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A Novel Fluorescent Probe for Rapid and Selective Detection of Fluoride Ions in Living Cells

Analytical Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

DTP specifically recognizes F − and allows for quantitative analysis in buffer solutions. In cellular imaging, releases red fluorescence upon recognition, enabling the visualization of fluoride within HepG2 cells.

Language: Английский

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Development of an efficient “turn-on” fluorescent probe for the detection of formaldehyde in cellular and environmental contexts

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112672 - 112672

Published: Jan. 1, 2025

Language: Английский

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A novel near-infrared fluorescent probe with large Stokes shift for monitoring γ-glutamyltranspeptidase in tumor and liver injury mice

Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112668 - 112668

Published: Jan. 4, 2025

Language: Английский

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Hypochlorous Acid-Activatable NIR Fluorescence/Photoacoustic Dual-Modal Probe with High Signal-to-Background Ratios for Imaging of Liver Injury and Plasma Diagnosis of Sepsis

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Hypochlorous acid can be employed as a biomarker for blood infection (such sepsis) and tissue damage drug-induced liver injury, DILI), the diagnosis of or achieved through detection hypochlorous in relevant biological samples. Considering complex environment diverse interferences living organisms plasma, developing new methods HClO with high signal-to-background ratios is particularly important, it improve accuracy quality imaging based on higher contrast, which makes clearer more accurate. Here, advantages NIR fluorescence/photoacoustic dual-modal probe, we reported acid-activatable probe (NIRF-PA-HClO) spirolactam ring-opening strategy this paper. NIRF-PA-HClO showed excellent NIRF/PA responses SBRs solution, cells, mice. Moreover, was successfully applied high-contrast DILI. Finally, plasma sepsis satisfactory results. In summary, above results proved that would potentially useful tool study physiological pathological roles HClO, investigation pathology therapeutic mechanisms hepatotoxicity, infection. Also, development provides design mentality constructing other analyte-activatable probes SBRs.

Language: Английский

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Advances in phototheranostic agents: From imaging to targeted therapy

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102516 - 102516

Published: Jan. 1, 2025

Language: Английский

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Chemiluminescent Probe for Enhanced Visualization of Renal Ischemia-Reperfusion Injury via Pyroglutamate Aminopeptidase-1 Activation

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The absence of an effective imaging tool for diagnosing renal ischemia-reperfusion injury (RIRI) severely delays its treatment, and currently, no definitive clinical interventions are available. Pyroglutamate aminopeptidase-1 (PGP-1), a potential inflammatory cytokine, has shown considerable as biomarker tracing the process in vivo. However, exact role enhanced visualization RIRI complex biological systems yet to be fully established. Chemiluminescence (CLI) proven one most promising diagnostic methods due ultrahigh-contrast capabilities compared fluorescence imaging. In this study, we developed activatable Schaap's dioxetane chemiluminescent probe (PGP-PD) explore PGP-1 marker CLI following ischemia-reperfusion, with goal achieving high-contrast situ diagnostics RIRI. vitro, PGP-PD exhibited exceptional selectivity exogenous remarkable sensitivity, detection limit low 2.244 ng/mL. Moreover, vivo studies successfully demonstrated positive correlation between level. Notably, generated significant signal within RIRI-kidney, providing exceptionally high contrast injured normal kidney tissue (∼9.4-fold) mouse model. We anticipate that work may offer valuable (PGP-1) powerful improving diagnosis, thereby aiding treatment planning surgical outcomes patients.

Language: Английский

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