The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

et al.

Developmental medico-life-sciences, Journal Year: 2024, Volume and Issue: 1(10), P. 4 - 22

Published: Dec. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Language: Английский

Diagnostic accuracy of ultrasound in hyperthyroidism: A comprehensive review of recent studies DOI

Dawei Wang,

Chao Xie,

Xuena Zheng

et al.

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101370 - 101370

Published: Feb. 26, 2025

Language: Английский

Citations

0
Editing Benzotrithiophene-Based Covalent Organic Frameworks for Developing New Sonosensitizers DOI
Chunyuan Hou,

Nan Han,

Bin Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent therapeutic effect. Particularly, because enhanced D-A effect that promotes charge separation transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight great potential elaborate editing configurations as suitable candidates advanced sonosensitizers.

Language: Английский

Citations

0
Precision diagnosis of burn injuries using imaging and predictive modeling for clinical applications DOI Creative Commons
Pramod Rangaiah, B. P. Pradeep Kumar, Fredrik Huss

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Burns represents a serious clinical problem because the diagnosis and assessment are very complex. This paper proposes methodology that combines use of advanced medical imaging with predictive modeling for improvement burn injury assessment. The proposed framework makes Adaptive Complex Independent Components Analysis (ACICA) Reference Region (TBSA) methods in conjunction deep learning techniques precise estimation depth Total Body Surface Area analysis. It also allows burns high accuracy, calculation TBSA, non-invasive analysis 96.7% accuracy using an RNN model. Extensive experimentation on DCE-LUV samples validates enhanced diagnostic precision detailed texture These technologies provide nuanced insights into severity, improving treatment planning. Our results demonstrate potential these to revolutionize care optimize patient outcomes.

Language: Английский

Citations

0
Near-infrared light-triggered in situ self-assembly nanomedicine for treating antibiotic-resistant bacterial infection DOI
Yu Zhang,

Chunhua Ren,

Huayang Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161303 - 161303

Published: March 1, 2025

Language: Английский

Citations

0
Well‐Defined Nanostructures: Concept, Impact and Perspective DOI Creative Commons

Ningxiang Wu,

Weidong Shi, Wenxin Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Well-defined nanostructures (WDNSs) represent a transformative frontier in nanotechnology, enabling precise control over material properties through nanoscale engineering. The connectivity of building blocks is increasingly critical defining the and applications WDNSs. Traditional dimensionality-based classifications provide foundational insights but overlook delicate influence architectures on functionality. This perspective introduces supplementary classification framework based modes, including discrete connections, serial 2.5D 3D interpenetrations. Each category defines specific structural configurations that decide spatial arrangement, interaction dynamics, functional integration components. establishes unique for understanding WDNSs, linking their design with diverse catalysis, energy storage, biomedicine, beyond. By regulating strategies emerging demands, WDNSs offer considerable opportunities designing multifunctional materials, providing foundation advancing nanotechnology addressing complex scientific societal challenges. Finally, advanced rational design, accurate synthesis, comprehensive deployment, sustainable development remain to bottlenecks development.

Language: Английский

Citations

0
Coated microbubble oscillation using a coupling model at varied ultrasonic parameters and bubble properties for biomedical application DOI Creative Commons
Yuxuan Song, Shanshan Qin, Ye Yu

et al.

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(3)

Published: March 1, 2025

Ultrasound-mediated techniques are very promising tools, and efforts needed to investigate ultrasound-responsive microbubbles (MBs) for medical applications. Serving a crucial role in optimizing the therapeutic effect, dynamics of MBs have been particular focus present studies. Because often exist form bubble clusters ultrasonic field, precise understanding interaction between ultrasound propagation oscillations should be paid attention to. In this paper, model coupling multi-bubble with nonlinear acoustic wave equations is proposed, oscillation coated analyzed under different circumstances. general agreement experimental results, numerical studies indicate that MB vary due bubble's initial radius, property, concentration. The promotion or suppression concentration on varies alternately larger changes resonance frequency. stable cavitation dose (SCD) increases increasing peak negative pressure pulse length. Moreover, SCD initially increased then decreased rapidly as further increased. This study presents an opportunity interplay cavitation, parameters biological effects future research from laboratory bench patient bedside.

Language: Английский

Citations

0
Development of Electrostatic Dual‐Carbon‐Fiber Microgrippers for Precise 2D Patterning and 3D Stacking of Single Microparticles DOI Open Access

MinMing Zai,

Tursunay Yibibulla,

Mohsin Shah

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract This study presents the development of electrostatic dual‐carbon‐fiber (CF) microgrippers for precise manipulation single SiO 2 microparticles (diameters >3 µm) at low operating voltages 5 to 15 V. Theoretical calculations and finite element analysis (FEA) simulations demonstrate that utilize a non‐uniform electric field generated by dual CF electrodes create dielectrophoresis force pick‐and‐place microparticle. After removal turning off voltage, particle release is facilitated van der Waals forces from substrate surface. approach eliminates need additional corona discharge fields or vibrational separators release, ensuring accurate 2D patterning 3D stacking microparticles. The show significant potential applications in individual separation assembly microparticles, such as lunar soil interstellar dust, well single‐cell extraction positioning. Additionally, developed offer broad utility micro/nano‐manufacturing, micro/nano‐electronic circuits, physics, chemistry, biomedicine.

Language: Английский

Citations

0
Disrupt Mitochondrial Proton Gradients via Flexoelectric Catalysis to Deplete Tumor Energy and Enhance Immunotherapy DOI Open Access

Yihan Fu,

Zichuang Xu,

H. F. Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Mitochondria, recognized as the cellular powerhouse, provide a continuous stream of energy essential for rapid proliferation and elevated metabolic demands tumor cells. Herein, flexoelectric nanocatalyst, SrTiO₃/RGD/TPP (SRT), is engineered to disrupt mitochondrial proton gradients ionic balance through ultrasound‐induced catalysis. This interference impedes production, resulting in cell apoptosis due an inadequate supply. Upon ultrasound stimulation, SRT experiences polarization stress gradient, separation positive negative charges, thereby generating local electric field. The charges interact with protons (H⁺) intermembrane space produce hydrogen (H₂), reducing concentration disrupting subsequently inhibiting ATP synthesis. Concurrently, field modifies membrane potential (MMP), opening calcium uniporter (MCU) channels facilitating influx ions, overload dysfunction, ultimately severing supply disruption energy, when combined immunotherapy, demonstrates significant inhibition both vitro vivo models. Through integration catalysis this study potent anti‐tumor effects proposes new research directions nanomedicine.

Language: Английский

Citations

0
A nanocatalytic membrane with sono-responsive antibacterial therapy (SRAT) for rapid sterilization and enhanced chronic wound healing DOI
Shuai He,

Lu Xie,

Daiquan Zhang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel PN-bioHJ membrane combining black phosphorus and barium titanate on a PLGA platform achieves >99% antibacterial efficiency under ultrasound, with excellent biocompatibility for infected tissue regeneration.

Language: Английский

Citations

0
X-ray/γ-ray/Ultrasound-Activated Persistent Luminescence Phosphors for Deep Tissue Bioimaging and Therapy DOI

Yurong Wei,

Jie Wang

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56519 - 56544

Published: Oct. 14, 2024

Persistent luminescence phosphors (PLPs) can remain luminescent after excitation ceases and have been widely explored in bioimaging therapy since 2007. In bioimaging, PLPs efficiently avoid tissue autofluorescence light scattering interference by collecting persistent signals the end of excitation. Outstanding signal-to-background ratios, high sensitivity, resolution achieved with PLPs. therapy, continuously produce therapeutic molecules such as reactive oxygen species removing sources, which realizes sustained activity a single dose stimulation. However, most are activated ultraviolet or visible light, makes it difficult to reactivate vivo, particularly deep tissues. recent years, sources penetration activate PLPs, including X-ray, γ-ray, ultrasound. Researchers found that various inorganic organic be ultrasound, making these valuable imaging deep-seated tumors. These X-ray/γ-ray/ultrasound-activated not systematically introduced previous reviews. this review, we summarize recently developed ultrasound luminescence. The biomedical applications deep-tissue also discussed. This review provide instructions for design deep-tissue-renewable further promote phototheranostics, noninvasive biosensing devices, energy harvesting.

Language: Английский

Citations

3