Metal–organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy–photodynamic therapy
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
novel
folic
acid-conjugated,
iron-based
metal
framework
MIL-101
(Fe)
MOF
loaded
with
1,8-acridinediones
(DO8)
was
developed
for
targeted
photodynamic
therapy
(PDT).
Language: Английский
Engineered Photoactivatable Nanomicelles for Ferroptosis-like Combinational Tumor Therapy In Vitro and In Vivo
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Nitric
oxide
(NO)-based
gas
therapy
has
attracted
increasing
attention
as
a
promising
approach
for
tumor
treatment,
but
elevated
levels
of
glutathione
(GSH)
in
the
microenvironment
significantly
limit
their
therapeutic
effectiveness.
In
this
study,
type
engineered
photoactivatable
nanomicelles
Ce6/NI@PEP@HA
(CNPH)
were
developed
combinational
photodynamic
and
NO
therapy.
CNPH
was
capable
targeted
accumulation
to
tumors,
where
it
depleted
GSH
released
effectively
produce
reactive
oxygen
species
(ROS)
with
oxidative
damage
under
laser
irradiation
at
660
nm.
The
consumption
induced
deactivation
peroxidase
activity,
leading
enhanced
toxic
lipid
peroxide
enabled
ferroptosis-like
outcome.
Additionally,
effective
production
ROS
resulted
mitochondrial
dysfunction,
characterized
by
disruption
membrane
potential
decreased
adenosine
triphosphate
concentration.
vivo
animal
experiments
indicated
that
achieved
inhibition
89.1%,
proven
be
more
strategy
contrast
any
single
modality.
consequence,
opened
up
new
horizon
cutting-edge
noninvasive
paradigm
advanced
treatments.
Language: Английский
Deciphering the tumor immune microenvironment: Microscale measurements for precision detection and multidimensional analysis
Lu Wang,
No information about this author
Fan Yin,
No information about this author
Rongping Luo
No information about this author
et al.
View,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
The
precision
of
cancer
immunotherapy
is
critically
dependent
on
accurately
characterizing
the
tumor
immune
microenvironment
(TIME),
which
represents
a
complex
interplay
cellular
components,
cytokines,
and
metabolic
factors.
Traditional
diagnostic
methods
lack
resolution
to
capture
dynamic
molecular
interactions
within
TIME
at
microscale
level.
This
review
focuses
recent
advancements
in
measurements
for
identifying
novel
immune‐oncology
biomarkers
therapeutic
targets
TIME,
emphasizing
importance
high‐fidelity
data
infiltrates
significance
longitudinal
high‐dimensional
analysis
predicting
treatment
responses.
Furthermore,
discusses
impact
reprogramming
potential
new
responses
immunotherapy.
role
nanotechnology
enhancing
detection
checkpoints
development
AI‐based
sensors
real‐time
predictive
modeling
also
explored,
highlighting
these
advanced
technologies
revolutionize
field
Language: Английский
Fe3O4@Bi2S3 Nanoparticles Mediated MRI-Guided Precision Radiosensitization for Orthotopic Glioblastoma via External Magnetism
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Radioresistance
in
tumors
and
the
excess
damage
normal
tissues
during
radiotherapy
(RT)
restrict
clinical
application
of
glioblastoma
RT.
Image-guided
radiosensitization
is
hopefully
adopted
to
achieve
precision
Nevertheless,
therapeutic
effect
radiosensitizers
unsatisfactory
due
limitations
blood–brain
barrier
poor
tumor
targeting.
Herein,
Fe3O4@Bi2S3
nanoparticles
coated
with
a
cell
membrane
(denoted
as
FBM)
have
been
designed
sensitize
FBM
accumulates
precisely
within
via
external
magnetism
homologous
adhesion
capability.
Afterward,
releases
high-Z
atoms
(Bismuth)
ionizing
radiation
micro
acidic
environments
that
interact
generate
high
densities
secondary
radiation,
which
leads
enhanced
dose
deposits.
Simultaneously,
generates
reactive
oxygen
species,
lipid
peroxidation
Fe2+,
depletes
glutathione,
downregulates
glutathione
peroxidase
4
activate
ferroptosis.
Notably,
growth
inhibition
rate
FBM-mediated
RT
increases
75.49%
orthotopic
model.
Besides,
magnetic
resonance
imaging
performance
shows
potential
diagnosis
therapy
surveillance,
thereby
reducing
adjacent
realizing
MRI-guided
Hence,
novel
multifunctional
nanoplatform
offers
for
image-guided
induced
by
activating
ferroptosis,
thus
presenting
an
efficient
radiotherapeutic
approach
glioblastoma.
Language: Английский
Manganese(III)-containing ionic liquids with liquid crystalline properties: Synthesis, structural insights, and functional applications
Next Materials,
Journal Year:
2025,
Volume and Issue:
8, P. 100682 - 100682
Published: May 9, 2025
Language: Английский
Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 16, 2025
Abstract
The
rapidly
advancing
field
of
theranostics
aims
to
integrate
therapeutic
and
diagnostic
functionalities
into
a
single
platform
for
precision
medicine,
enabling
the
simultaneous
treatment
monitoring
diseases.
Photo‐energy
conversion‐based
nanomaterials
have
emerged
as
versatile
that
utilizes
unique
properties
light
activate
with
high
spatial
temporal
precision.
This
review
provides
comprehensive
overview
recent
developments
in
photo‐energy
conversion
using
nanomaterials,
highlighting
their
applications
disease
theranostics.
discussion
begins
by
exploring
fundamental
principles
including
types
materials
used
various
light‐triggered
mechanisms,
such
photoluminescence,
photothermal,
photoelectric,
photoacoustic,
photo‐triggered
SERS,
photodynamic
processes.
Following
this,
delves
broad
spectrum
emphasizing
role
diagnosis
major
diseases,
cancer,
neurodegenerative
disorders,
retinal
degeneration,
osteoarthritis.
Finally,
challenges
opportunities
technologies
are
discussed,
aiming
advance
personalized
medicine.
Language: Английский
Smart nanomaterials for multimodal theranostics and tissue regeneration
Coordination Chemistry Reviews,
Journal Year:
2025,
Volume and Issue:
541, P. 216801 - 216801
Published: May 17, 2025
Language: Английский
Promising biomedical applications using superparamagnetic nanoparticles
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: June 2, 2025
Abstract
Magnetic
nanoparticles
(MNPs)
have
emerged
as
powerful
tools
in
biomedicine
due
to
their
distinct
physicochemical
characteristics,
including
a
high
surface-area-to-volume
ratio,
adjustable
size,
magnetic
sensitivity,
and
compatibility
with
biological
systems.
These
properties
enable
precise
control
through
external
fields,
making
MNPs
highly
effective
targeted
therapeutic
diagnostic
applications.
Although
not
inherently
intelligent,
they
can
exhibit
programmable
responsive
behavior
under
influence,
enhancing
utility
drug
delivery
hyperthermia-based
treatments.
In
the
medical
field,
been
extensively
explored
for
role
resonance
imaging
(MRI)
enhancement,
selective
transport,
hyperthermia
cancer
therapy,
biomolecular
separation.
Within
oncology,
facilitate
direct
of
compounds
tumors,
reducing
systemic
side
effects
increasing
treatment
specificity.
Additionally,
capacity
produce
localized
heat
when
exposed
alternating
fields
makes
them
instrumental
where
malignant
cells
are
selectively
eradicated.
A
key
advantage
is
adaptable
surface
chemistry,
which
allows
functionalization
biocompatible
polymers,
ligands,
other
stabilizing
agents.
modifications
enhance
stability,
minimize
immune
responses,
optimize
performance
physiological
environments.
Functionalized
contributed
significantly
improving
MRI
contrast,
refining
mechanisms,
effectiveness
This
review
examines
recent
breakthroughs
MNP-based
technologies,
an
emphasis
on
tumor
targeting,
across
blood–brain
barrier,
Language: Английский
Nanostructured Bubble Thin Films—From Simple Fabrication to Scalable Applications: A Review
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(11), P. 868 - 868
Published: June 4, 2025
Several
applications
for
nanotechnology
necessitate
the
assembly
of
nanomaterials
over
large
areas
with
precise
orientation
and
density.
Some
techniques,
such
as
Langmuir–Blodgett,
contact
printing,
electric
field
directed
assembly,
flow-assisted
alignment,
have
been
used
to
meet
a
requirement.
However,
it
remains
uncertain
whether
these
techniques
can
be
scaling
up
nanomaterial
thin
films
onto
solid
flexible
substrates.
Accordingly,
this
review
paper
addresses
an
issue
by
reviewing
two
recent
scalable
methods:
blown
bubble
(BBFs)
deposition
method
(BDM).
It
specifically
offers
comprehensive
account
film
methods
along
their
applications.
also
discusses
how
are
made
fabricate
devices.
finally
provides
some
recommendations
further
research
Language: Английский