Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100682 - 100682
Published: May 9, 2025
Language: Английский
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A novel folic acid-conjugated, iron-based metal framework MIL-101 (Fe) MOF loaded with 1,8-acridinediones (DO8) was developed for targeted photodynamic therapy (PDT).
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Nitric oxide (NO)-based gas therapy has attracted increasing attention as a promising approach for tumor treatment, but elevated levels of glutathione (GSH) in the microenvironment significantly limit their therapeutic effectiveness. In this study, type engineered photoactivatable nanomicelles Ce6/NI@PEP@HA (CNPH) were developed combinational photodynamic and NO therapy. CNPH was capable targeted accumulation to tumors, where it depleted GSH released effectively produce reactive oxygen species (ROS) with oxidative damage under laser irradiation at 660 nm. The consumption induced deactivation peroxidase activity, leading enhanced toxic lipid peroxide enabled ferroptosis-like outcome. Additionally, effective production ROS resulted mitochondrial dysfunction, characterized by disruption membrane potential decreased adenosine triphosphate concentration. vivo animal experiments indicated that achieved inhibition 89.1%, proven be more strategy contrast any single modality. consequence, opened up new horizon cutting-edge noninvasive paradigm advanced treatments.
Language: Английский
Citations
0
View, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Abstract The precision of cancer immunotherapy is critically dependent on accurately characterizing the tumor immune microenvironment (TIME), which represents a complex interplay cellular components, cytokines, and metabolic factors. Traditional diagnostic methods lack resolution to capture dynamic molecular interactions within TIME at microscale level. This review focuses recent advancements in measurements for identifying novel immune‐oncology biomarkers therapeutic targets TIME, emphasizing importance high‐fidelity data infiltrates significance longitudinal high‐dimensional analysis predicting treatment responses. Furthermore, discusses impact reprogramming potential new responses immunotherapy. role nanotechnology enhancing detection checkpoints development AI‐based sensors real‐time predictive modeling also explored, highlighting these advanced technologies revolutionize field
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.
Language: Английский
Citations
0
Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100682 - 100682
Published: May 9, 2025
Language: Английский
Citations
0