Engineered Bdellovibrio bacteriovorus enhances antibiotic penetration and biofilm eradication

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 283 - 296

Published: Feb. 6, 2025

Language: Английский

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A Review on Recent Trends in Bacteriophages for Post-Harvest Food Decontamination

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 515 - 515

Published: Feb. 27, 2025

Infectious diseases resulting from unsafe food consumption are a global concern. Despite recent advances and control measures in the industry aimed at fulfilling growing consumer demand for high-quality safe products, infection outbreaks continue to occur. This review stands out by providing an overview of post-harvest decontamination methods against some most important bacterial foodborne pathogens, with particular focus on advantages challenges using phages, including their applications directly integration into active packaging systems, highlighting potential safer healthier products. The already approved commercial phage products numerous available studies demonstrate antibacterial efficacy problematic pathogens different reinforcing possible use future as current practice decontamination. Moreover, incorporation phages materials holds promise, protection harsh conditions enabling controlled continuous release matrix. effectiveness phage-added reducing growth systems has been well-demonstrated. However, there still associated development phage-based that need be addressed research.

Language: Английский

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Bacteriophage-Based Therapies in Oral Cancer: A New Frontier in Oncology

Cancer Pathogenesis and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Reviving hope: Phage therapy application for antimicrobial resistance in farm animal production over the past decade

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116333 - 116333

Published: April 1, 2025

Language: Английский

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Photosensitive materials armed bacteriophages: Latest advances and prospects

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162429 - 162429

Published: April 1, 2025

Language: Английский

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Epidemiological and genomic features of clinical isolates of the Elizabethkingia genus in Taizhou City, China

Journal of Global Antimicrobial Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Elizabethkingia species usually exhibit resistance to multiple antibiotics, and inappropriate antimicrobial therapy is a major cause of mortality in patients with infection. Our study aimed comprehensively analyze compare the genomic clinical features three species. Matrix-assisted laser desorption/ionization-time flight mass spectrometry whole-genome sequencing were used identify 88 isolates from past 6 years. Phylogenetic tree Sankey diagram analysis strains metallo-β-lactamase genes 49 miricola evolutionary relationships. The identified included anophelis (65/88,73.9%), meningoseptica (8/88, 9.1%), (15/88, 17.0%). Multivariate showed that co-isolated Pseudomonas aeruginosa (odds ratio: 40.83, 95% confidence interval: 3.05-546.29, p = 0.005) exposure carbapenems 5.76, 1.00-248.32, 0.050) independent risk factors for in-hospital mortality. Whole-genome phylogenetic revealed all 22 BlaBlaB 19 BlaGOB variants. In particular, specific combinations BlaB GOB subtypes differed All harbored drug-resistance adeF, vanT, vanW shared 32 virulence-associated genes. Global evolution E. dispersal Chinese did not display outbreak possibility. Variations virulence are associated natural pathogenicity Elizabethkingia. Increased monitoring recommended deeper understanding pathogenic mechanisms spp.

Language: Английский

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Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 469 - 469

Published: April 29, 2025

Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins nucleic acids, coupled modifiable biologically unique properties, enables them serve efficient safe delivery systems. Unlike conventional nanocarriers, which face limitations such non-specific targeting, cytotoxicity, reduced transfection efficiency vivo, engineered phages exhibit promising potential overcome these hurdles improve outcomes. This review highlights bacteriophage-based systems innovative for delivering therapeutic agents. It explores strategies engineering bacteriophage, categorizes principal types employed delivery, evaluates applications disease therapy. provides intriguing details use natural therapy diseases cancer, bacterial viral infections, veterinary diseases, neurological disorders, well phage display technology generating monoclonal antibodies against various human diseases. Additionally, CRISPR-Cas9 genetically is elucidated. Furthermore, it critical analysis challenges associated phage-based systems, offering insights overcoming obstacles. By showcasing advancements integration into nanotechnology, this study underscores revolutionize approaches inspire future innovations medicine.

Language: Английский

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Bimetallic organic framework-derived multifunctional signal marker-driven ultra-magnetic nanoplatform for sensitive detection and efficient sterilization of methicillin-resistant Staphylococcus aureus

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 514, P. 163250 - 163250

Published: May 1, 2025

Language: Английский

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