Piezoelectric Amplification of Cascade Enzymatic Catalysis and Nanomotor Propulsion for Synergistic Electrodynamic‐Starvation Tumor Therapy DOI

Zhanlin Zhang,

Kun Wei,

Jie Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation constrained insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling potential‐amplified activities synergistic PEDT‐starvation tumor therapy. Here hollow barium titanate (hBT) NPs synthesized using SiO 2 templates, followed partial Au deposition via the Pickering emulsion‐masking method create hBT@Au NPs, which then conjugated with GOx CAT on opposing sides yield C‐hBT@Au‐G NPs. The structure hBT enhances flexibility deformation under ultrasonication, Schottky heterojunctions layers promote charge carrier transfer, amplifying effects free electron transfer boost Piezoelectric field‐enhances selective cell internalization PEDT generation reactive oxygen species (ROS), coupled self‐propagated GOx/CAT cascades, intensify cytotoxicities deplete intracellular adenosine triphosphate. architecture, ultrasonic cavitation, O collaboratively drive robust propulsion for efficient NP accumulation deep ROS penetration into tissues, thereby achieving full suppression negligible systemic toxicity. This design overcomes delivery barriers accumulation, intratumoral penetration, cellular uptake synergizes

Language: Английский

Vanadium Pentoxide Nanobelts for Lactose Oxidase-Like and Peroxidase-Like Cascade Reactions for Colorimetric Detection of Lactose in Milk DOI
Huihui Su,

Ruobo Chen,

Yi Fan

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

Citations

1
Advanced materials for cancer treatment and beyond DOI Creative Commons
Lei Zhang, Yanan Wang,

Yang‐Jia Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

Conservative anti-cancer treatment represented by chemotherapy and surgery lacks tumor-specificity could hardly resolve the problems associated with multidrug resistance (MDR) in cancers. Novel therapeutic materials cancer treatment, such as those anti-MDR or controllable features, represent a significant trend due to their advantages of high specific efficacy timely intervention progress. In addition excellent biocompatibility specificity, they can be utilized therapies that require ease operation, provided are designed detection sensitivity. this review, we summarize series recently developed exhibit these advantages, including immune-enhancing tumor microenvironment (TME)- responsive materials, integrated imaging capabilities. We also introduce advanced modification approaches impart essential targeting functionalities materials.

Language: Английский

Citations

0
Redox-driven hybrid nanoenzyme dynamically activating ferroptosis and disulfidptosis for hepatocellular carcinoma theranostics DOI Creative Commons

Qiao-Mei Zhou,

Yuan‐Fei Lu,

Xiaoyan Yang

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137611 - 137611

Published: April 15, 2025

Language: Английский

Citations

0
Rationally constructing the theranostics hydrogels for targeted CT imaging and healing of inflammatory bowel disease DOI

Zongling Xiong,

Feng Cai, Jingyi Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162986 - 162986

Published: April 1, 2025

Language: Английский

Citations

0
Piezoelectric Amplification of Cascade Enzymatic Catalysis and Nanomotor Propulsion for Synergistic Electrodynamic‐Starvation Tumor Therapy DOI

Zhanlin Zhang,

Kun Wei,

Jie Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation constrained insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling potential‐amplified activities synergistic PEDT‐starvation tumor therapy. Here hollow barium titanate (hBT) NPs synthesized using SiO 2 templates, followed partial Au deposition via the Pickering emulsion‐masking method create hBT@Au NPs, which then conjugated with GOx CAT on opposing sides yield C‐hBT@Au‐G NPs. The structure hBT enhances flexibility deformation under ultrasonication, Schottky heterojunctions layers promote charge carrier transfer, amplifying effects free electron transfer boost Piezoelectric field‐enhances selective cell internalization PEDT generation reactive oxygen species (ROS), coupled self‐propagated GOx/CAT cascades, intensify cytotoxicities deplete intracellular adenosine triphosphate. architecture, ultrasonic cavitation, O collaboratively drive robust propulsion for efficient NP accumulation deep ROS penetration into tissues, thereby achieving full suppression negligible systemic toxicity. This design overcomes delivery barriers accumulation, intratumoral penetration, cellular uptake synergizes

Language: Английский

Citations

0