Toward Microbial Recycling and Upcycling of Plastics: Prospects and Challenges DOI Creative Commons
Jo-Anne Verschoor, Hadiastri Kusumawardhani, Arthur F. J. Ram

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: March 23, 2022

Annually, 400 Mt of plastics are produced which roughly 40% is discarded within a year. Current plastic waste management approaches focus on applying physical, thermal, and chemical treatments polymers. However, these methods have severe limitations leading to the loss valuable materials resources. Another major drawback rapid accumulation into environment causing one biggest environmental threats twenty-first century. Therefore, complement current novel routes toward degradation upcycling need be developed. Enzymatic conversion present promising approach sustainable recycling building blocks. quest for enzymes that efficiently operate in cost-effective, large-scale poses many challenges. To date, wide range experimental set-ups has been reported, cases lacking detailed investigation microbial species exhibiting degrading properties as well their corresponding enzymes. The apparent lack consistent compromises necessary discovery In this review, we discuss prospects possibilities efficient enzymatic degradation, recycling, plastics, correlation with diversity broad utilization. identification optimization compared discussed. We framework standardized workflow, allowing transparent future.

Language: Английский

Bioplastics for Food Packaging: Environmental Impact, Trends and Regulatory Aspects DOI Creative Commons
Rui M.S. Cruz, Victoria Krauter, Simon Krauter

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(19), P. 3087 - 3087

Published: Oct. 5, 2022

The demand to develop and produce eco-friendly alternatives for food packaging is increasing. huge negative impact that the disposal of so-called “single-use plastics” has on environment propelling market search new solutions, requires initiatives drive faster responses from scientific community, industry, governmental bodies adoption implementation materials. Bioplastics are an alternative group materials partly or entirely produced renewable sources. Some bioplastics biodegradable even compostable under right conditions. This review presents different properties these materials, mechanisms biodegradation, their environmental impact, but also a holistic overview most important available in potential application packaging, consumer perception bioplastics, regulatory aspects, future challenges.

Language: Английский

Citations

84
Synthetic dioxygenase reactivity by pairing electrochemical oxygen reduction and water oxidation DOI
Md Asmaul Hoque, James B. Gerken, Shannon S. Stahl

et al.

Science, Journal Year: 2024, Volume and Issue: 383(6679), P. 173 - 178

Published: Jan. 11, 2024

The reactivity of molecular oxygen is crucial to clean energy technologies and green chemical synthesis, but kinetic barriers complicate both applications. In dioxygen should be able undergo atom transfer two organic molecules with perfect economy, such rare. Monooxygenase enzymes commonly reductively activate by sacrificing one the atoms generate a more reactive oxidant. Here, we used manganese-tetraphenylporphyrin catalyst pair electrochemical reduction water oxidation, generating manganese-oxo at electrodes. This process supports thioether substrate molecules, equivalents sulfoxide single equivalent dioxygen. net dioxygenase consumes no electrons uses overcome barriers.

Language: Английский

Citations

37
Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity DOI Creative Commons
Ruijie K. Zhang, Xiongyi Huang, Frances H. Arnold

et al.

Current Opinion in Chemical Biology, Journal Year: 2018, Volume and Issue: 49, P. 67 - 75

Published: Oct. 18, 2018

Language: Английский

Citations

132
Nitrene Transfer Reactions for Asymmetric C–H Amination: Recent Development DOI
Hiroki Hayashi, Tatsuya Uchida

European Journal of Organic Chemistry, Journal Year: 2019, Volume and Issue: 2020(8), P. 909 - 916

Published: Dec. 18, 2019

C–H bonds are ubiquitous and abundant in organic molecules. If could be directly converted to desired functional groups a chemo‐, site‐, stereoselective manner, functionalization would strong useful tool for synthesis. Recent developments catalytic enzymatic chemistry have achieved highly sustainable selective nitrene insertion. Initially, amination was inspired by model studies on oxidation used iminoiodinanes, nitrogen analogs of iodosobenzene, as precursors. Transition‐metal/iminoiodinane systems well studied established. These can introduce sulfonamide with excellent stereoselectivity, albeit co‐production iodobenzene waste material. Fortunately, the atom economics this methodology were improved introducing sources such azide compounds 1,2,4‐dioxazol‐5‐one derivatives. In review, we present details these respect their catalysts sources.

Language: Английский

Citations

121
Broadening the scope of biocatalytic C–C bond formation DOI
Lara Zetzsche, Alison R. H. Narayan

Nature Reviews Chemistry, Journal Year: 2020, Volume and Issue: 4(7), P. 334 - 346

Published: June 3, 2020

Language: Английский

Citations

106
Rhodium(III)‐Catalyzed Enantio‐ and Diastereoselective C−H Cyclopropylation of N‐Phenoxylsulfonamides: Combined Experimental and Computational Studies DOI
Guangfan Zheng, Zhi Zhou, Guoxun Zhu

et al.

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(7), P. 2890 - 2896

Published: Dec. 9, 2019

Cyclopropane rings are a prominent structural motif in biologically active molecules. Enantio- and diastereoselective construction of cyclopropanes through C-H activation arenes coupling with readily available cyclopropenes is highly appealing but remains challenge. A dual directing-group-assisted strategy was used to realize mild redox-neutral RhIII -catalyzed cyclopropylation N-phenoxylsulfonamides enantioselective, diastereoselective, regioselective fashion cyclopropenyl secondary alcohols as cyclopropylating reagent. Synthetic applications demonstrated highlight the potential developed method. Integrated experimental computational mechanistic studies revealed that reaction proceeds via RhV nitrenoid intermediate, Noyori-type outer sphere concerted proton-hydride transfer from alcohol Rh=N bond produces observed trans selectivity.

Language: Английский

Citations

88
The relationships between cytochromes P450 and H 2 O 2 : Production, reaction, and inhibition DOI
Matthew E. Albertolle, F. Peter Guengerich

Journal of Inorganic Biochemistry, Journal Year: 2018, Volume and Issue: 186, P. 228 - 234

Published: May 23, 2018

Language: Английский

Citations

87
Origin and evolution of the CYP4G subfamily in insects, cytochrome P450 enzymes involved in cuticular hydrocarbon synthesis DOI
René Feyereisen

Molecular Phylogenetics and Evolution, Journal Year: 2019, Volume and Issue: 143, P. 106695 - 106695

Published: Dec. 2, 2019

Language: Английский

Citations

87
Cleaving arene rings for acyclic alkenylnitrile synthesis DOI
Xu Qiu,

Yue‐Qian Sang,

Hao Wu

et al.

Nature, Journal Year: 2021, Volume and Issue: 597(7874), P. 64 - 69

Published: July 19, 2021

Language: Английский

Citations

86
Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate DOI Creative Commons

Savvas Louka,

Sarah M. Barry, Derren J. Heyes

et al.

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(37), P. 15764 - 15779

Published: Aug. 19, 2020

The cytochromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body related to biodegradation and biosynthesis. They typically act as mono-oxygenases; however, recently discovered subfamily TxtE utilizes O2 NO nitrate aromatic substrates such L-tryptophan. A direct selective nitration may be useful biotechnology for synthesis of drugs or small molecules. Details catalytic mechanism unknown, it has been suggested should proceed through either an iron(III)-superoxo iron(II)-nitrosyl intermediate. To resolve this controversy, we used stopped-flow kinetics provide evidence a cycle where dioxygen binds prior generate active iron(III)-peroxynitrite species is able l-Trp efficiently. We show rate binding faster than also leads nitration, while little product formation observed from complex. support experimental studies, performed density functional theory studies on large site cluster models. suggest involving splits homolytically form iron(IV)-oxo heme (Compound II) free NO2 radical via energy activation. latter activates substrate ring, compound II picks up ipso-hydrogen product. calculations give barriers most steps and, therefore, predict fast These findings first detailed insight into by member highlight how enzyme facilitates novel chemistry.

Language: Английский

Citations

81