Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 303 - 326

Published: April 18, 2023

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable delivery, diverse cargo loading capacity. Although microneedles are initially designed penetrate stratum corneum of skin for transdermal they, recently, have been used promote wound healing regeneration tissues organs the results promising. Despite there reviews about microneedles, few them focus on tissue regeneration. Here, we review recent advances in this field. We first give an overview microneedle system terms potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs multidrug structures, adhesive structures), material selection, release mechanisms. Then briefly summarize different fabrication methods, including their advantages limitations. finally progress microneedle-assisted skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, uterine tissues). expect that our article would serve guideline readers design systems according applications, structure design, achieving better efficacy.

Language: Английский

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A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers

Advanced Science, Journal Year: 2021, Volume and Issue: 8(24)

Published: Nov. 1, 2021

Abstract Detection of biomarkers associated with body conditions provides in‐depth healthcare information and benefits to disease management, where the key challenge is develop a minimally invasive platform ability directly detect multiple in fluid. Dermal tattoo biosensor holds potential simultaneously health‐related skin interstitial fluid because features minimal invasion, easy operation, equipment‐free result reading. Herein, colorimetric dermal fabricated by four‐area segmented microneedle patch developed for multiplexed detection biomarkers. The exhibits color changes response change biomarker concentration (i.e., pH, glucose, uric acid, temperature), which can be read naked eyes or captured camera semi‐quantitative measurement. It demonstrated that vitro, ex vivo, monitor at least 4 days, showing its great long‐term health monitoring.

Language: Английский

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Recent Advances in Intelligent Wearable Medical Devices Integrating Biosensing and Drug Delivery

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(27)

Published: Jan. 10, 2022

Abstract The primary roles of precision medicine are to perform real‐time examination, administer on‐demand medication, and apply instruments continuously. However, most current therapeutic systems implement these processes separately, leading treatment interruption limited recovery in patients. Personalized healthcare smart medical have greatly promoted research on development biosensing drug‐delivery integrated systems, with intelligent wearable devices (IWMDs) as typical which received increasing attention because their non‐invasive customizable nature. Here, the latest progress IWMDs is reviewed, including mechanisms integrating drug delivery. challenges future directions also discussed.

Language: Английский

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Carbon-based nanomaterials for the detection of volatile organic compounds: A review

Carbon, Journal Year: 2021, Volume and Issue: 180, P. 274 - 297

Published: May 12, 2021

Language: Английский

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Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 458, P. 214438 - 214438

Published: Feb. 3, 2022

Language: Английский

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