Engineering nanobodies for next-generation molecular imaging DOI

Erpeng Yang,

Qiufang Liu,

Gang Huang

et al.

Drug Discovery Today, Journal Year: 2022, Volume and Issue: 27(6), P. 1622 - 1638

Published: March 21, 2022

Language: Английский

Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics DOI Creative Commons
Hidefumi Mukai, Koki Ogawa, Naoya Kato

et al.

Drug Metabolism and Pharmacokinetics, Journal Year: 2022, Volume and Issue: 44, P. 100450 - 100450

Published: Feb. 5, 2022

Language: Английский

Citations

59
Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11 DOI Creative Commons

Duanfeng Jiang,

Xin Wu,

Xiaoying Sun

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Jan. 10, 2022

Acute myeloid leukemia (AML) is a malignant clonal disease of hematopoietic stem- and progenitor-cell origin. AML features massive proliferation abnormal blasts cells in the bone marrow inhibition normal hematopoiesis at onset. Exosomes containing proteins or nucleic acids are secreted by cells; they participate intercellular communication serve as key modulators hematopoiesis. The purpose this study was to investigate effects exosomes derived from mesenchymal stem (BMSCs) on regulation underlying mechanisms mediated microRNA (miRNA).Dysregulated miR-7-5p patients identified using qRT-PCR its clinical significance explored. Bioinformatic analysis revealed target gene OSBPL11 that could be regulated miR-7-5p. findings were validated dual-luciferase reporter assay western blotting. functional genes PI3K/AKT/mTOR signaling pathway identified, determined recovery assay. co-cultured with originating BMSCs overexpressing determine cell-cell Exo-miR-7-5p, well vitro vivo validation via gain- loss-of-function methods.Expression decreased cells. Overexpression curbed cellular promoted apoptosis. reversed tumorigenic properties vitro. Exo-miR-7-5p induced formation prone apoptosis low survival rate, expression inhibited through pathway. exhibited tumor homing vivo, development.Exo-miR-7-5p negatively regulates suppressing phosphorylation pathway, thereby inhibiting promoting data will inform development therapies based BMSC-derived exosomes.

Language: Английский

Citations

58
GPC3-targeted immunoPET imaging of hepatocellular carcinomas DOI
Shuxian An, Di Zhang, You Zhang

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2022, Volume and Issue: 49(8), P. 2682 - 2692

Published: Feb. 11, 2022

Language: Английский

Citations

56
Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation DOI
Haonan Li, Qiang Luo, Hu Zhang

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 47 - 96

Published: Nov. 25, 2022

This review overviews the landscape of nanomedicine-aided cancer radio-immunotherapy in a “from bench to clinic” manner.

Language: Английский

Citations

47
Engineering nanobodies for next-generation molecular imaging DOI

Erpeng Yang,

Qiufang Liu,

Gang Huang

et al.

Drug Discovery Today, Journal Year: 2022, Volume and Issue: 27(6), P. 1622 - 1638

Published: March 21, 2022

Language: Английский

Citations

41