Tissue Engineering Part B Reviews,
Journal Year:
2020,
Volume and Issue:
27(5), P. 486 - 513
Published: Oct. 29, 2020
Methylcellulose
(MC)
is
an
attractive
material
used
to
produce
thermo-responsive
hydrogels.
They
undergo
sol-gel
transition
when
a
critical
temperature
reached,
thus
modifying
their
properties
(e.g.,
physicochemical
and
mechanical)
in
response
changes.
This
behavior
particularly
the
body
acts
as
trigger
modulate
of
MC
In
this
regard,
exciting
advances
have
been
achieved
field
cell
drug
delivery,
tissue
engineering,
regenerative
medicine,
making
very
versatile
biomaterial.
review
aims
present
hydrogels,
examining
preparation,
physical
properties,
tunability
thermal
response,
lastly
moving
comprehensive
depiction
both
conventional
innovative
applications
for
regeneration
purposes.
particular,
three
main
families
are
introduced:
(1)
situ
gelling
systems,
which
upon
delivery
into
target
site
or
organ),
assisting
latter
presence
absence
loading
components
cells,
biomolecules,
inorganic
materials);
(2)
three-dimensional
(3D)
(bio)printing,
where
induced
by
heating
MC-based
(bio)inks
after
printing,
obtaining
3D
tissue-engineered
substitutes
with
defined
geometries
high
shape
fidelity;
(3)
smart
culture
surfaces,
hydrophilic/hydrophobic
exploited
reach
selective
attachment/detachment
offering
possibility
obtain
sheets
bodies
reconstruction
without
need
any
proteolytic
enzyme.
The
limitations
hydrogels
will
be
then
examined,
together
current
solutions
overcome
them.
Moreover,
overview
future
directions
given,
particular
focus
on
design
multiresponsive
systems
capable
respond
multiple
stimuli
chemical
biological
stimuli),
toward
development
more
patient-specific
treatments.
Finally,
patents
clinical
trials
describing
use
retracing
abovementioned
application.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 345 - 345
Published: Jan. 19, 2023
Tissue
engineering
(TE)
is
a
rapidly
expanding
field
aimed
at
restoring
or
replacing
damaged
tissues.
In
spite
of
significant
advancements,
the
implementation
TE
technologies
requires
development
novel,
highly
biocompatible
three-dimensional
tissue
structures.
this
regard,
use
peptide
self-assembly
an
effective
method
for
developing
various
structures
and
surface
functionalities.
Specifically,
arginine–glycine–aspartic
acid
(RGD)
family
peptides
known
to
be
most
prominent
ligand
extracellular
integrin
receptors.
Due
their
specific
expression
patterns
in
human
tissues
tight
association
with
pathophysiological
conditions,
RGD
are
suitable
targets
regeneration
treatment
as
well
organ
replacement.
Therefore,
RGD-based
ligands
have
been
widely
used
biomedical
research.
This
review
article
summarizes
progress
made
application
development.
Furthermore,
we
examine
effect
structure
sequence
on
efficacy
clinical
preclinical
studies.
Additionally,
outline
recent
advancement
functionalized
biomaterials
tissues,
including
corneal
repair,
artificial
neovascularization,
bone
TE.
Three-dimensional
(3D)
printing
is
emerging
as
a
transformative
technology
for
biomedical
engineering.
The
3D
printed
product
can
be
patient-specific
by
allowing
customizability
and
direct
control
of
the
architecture.
trial-and-error
approach
currently
used
developing
composition
printable
inks
time-
resource-consuming
due
to
increasing
number
variables
requiring
expert
knowledge.
Artificial
intelligence
has
potential
reshape
ink
development
process
forming
predictive
model
printability
from
experimental
data.
In
this
paper,
we
constructed
machine
learning
(ML)
algorithms
including
decision
tree,
random
forest
(RF),
deep
(DL)
predict
biomaterials.
A
total
210
formulations
16
different
bioactive
smart
materials
4
solvents
were
printed,
their
was
assessed.
All
ML
methods
able
learn
variety
based
on
biomaterial
formulations.
particular,
RF
algorithm
achieved
highest
accuracy
(88.1%),
precision
(90.6%),
F1
score
(87.0%),
indicating
best
overall
performance
out
3
algorithms,
while
DL
recall
(87.3%).
Furthermore,
have
predicted
window
biomaterials
guide
development.
map
generated
with
finer
granularity
than
other
algorithms.
proven
an
effective
novel
strategy
desired
engineering
applications.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
240, P. 112853 - 112853
Published: March 19, 2024
3D
bioprinting
techniques
have
emerged
as
a
flexible
tool
in
tissue
engineering
and
regenerative
medicine
to
fabricate
or
pattern
functional
bio-structures
with
precise
geometric
designs,
bridging
the
divergence
between
engineered
natural
constructs.
A
significantly
increasing
development
has
been
achieved
understanding
relationship
3D-printing
process
structures,
properties,
applications
of
objects
created.
The
ongoing
advancement
novel
biomaterial
inks
enabled
manufacturing
models
vitro
implants
capable
achieving
some
level
success
preclinical
trials.
Remarkable
progress
cell
biology
biology-inspired
computational
design
assisted
latest
milestone
planned
tissue-
organ-like
constructs
having
specific
levels
functionality.
However,
biofabricated
still
long
way
go
before
reaching
clinics.
This
review
presents
picture
context
medicine,
focus
on
biomaterials-related
design-centred
aspects.
Biomedical
are
described
detail
relation
major
tissues
organs
considered
human
body.
Current
technical
limitations,
challenges,
future
prospects
improvements
critically
outlined
discussed.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 348 - 377
Published: April 23, 2024
Setting
time
as
the
fourth
dimension,
4D
printing
allows
us
to
construct
dynamic
structures
that
can
change
their
shape,
property,
or
functionality
over
under
stimuli,
leading
a
wave
of
innovations
in
various
fields.
Recently,
smart
biomaterials,
biological
components,
and
living
cells
into
3D
constructs
with
effects
has
led
an
exciting
field
bioprinting.
bioprinting
gained
increasing
attention
is
being
applied
create
programmed
cell-laden
such
bone,
cartilage,
vasculature.
This
review
presents
overview
on
for
engineering
tissues
organs,
followed
by
discussion
approaches,
technologies,
biomaterials
design,
bioink
requirements,
applications.
While
much
progress
been
achieved,
complex
process
facing
challenges
need
be
addressed
transdisciplinary
strategies
unleash
full
potential
this
advanced
biofabrication
technology.
Finally,
we
present
future
perspectives
rapidly
evolving
bioprinting,
view
its
potential,
increasingly
important
roles
development
basic
research,
pharmaceutics,
regenerative
medicine.
Advances in healthcare information systems and administration book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 132 - 152
Published: Feb. 14, 2024
Among
the
various
manufacturing
processes
currently
in
use
by
industry,
3D
printing
stands
out
as
a
unique
additive
technique.
It
enables
creation
of
three-dimensional
solid
objects
virtually
any
shape
from
digital
model.
Initially
considered
an
ambitious
concept,
medical
has
become
reality
thanks
to
substantial
time
and
investment.
This
chapter
delves
into
recent
advancements
within
modern
field,
offering
concise
overview
how
why
is
transforming
practices,
education,
research.
serves
introduction
subject,
followed
demonstration
state-of-the-art
through
industry
developments.
The
significance
this
lies
its
comprehensive
coverage
evolving
role
healthcare,
highlighting
not
only
current
applications
challenges
but
also
underscoring
potential
revolutionize
aspects
science
patient
care.
Smart Materials in Medicine,
Journal Year:
2024,
Volume and Issue:
5(2), P. 183 - 195
Published: Jan. 12, 2024
Since
the
need
for
vascular
networks
to
supply
oxygen
and
nutrients
while
expelling
metabolic
waste,
most
cells
can
only
survive
within
200
μm
of
blood
vessels;
thus,
construction
well-developed
vessel
is
essential
manufacture
artificial
tissues
organs.
Three-dimensional
(denoted
as
3D)
printing
a
scalable,
reproducible
high-precision
manufacturing
technology.
In
past
several
years,
there
have
been
many
breakthroughs
in
building
various
vascularized
tissues,
greatly
promoting
development
biological
tissue
engineering.
This
paper
highlights
latest
progress
3D
printed
organs,
including
heart,
liver,
lung,
kidney,
penis.
We
also
discuss
application
status
potential
above
prospect
further
requirement
technology
clinically
useable
tissues.
Discover Materials,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 9, 2025
Achieving
the
ideal
replacement
for
robust
biological
tissues
requires
biocompatible
materials
with
a
nuanced
blend
of
characteristics,
including
organ
specific
toughness,
durability,
self-repairing
capability,
and
well-defined
structure.
Hydrogels,
structured
high
water
containing
3D-crosslinked
polymeric
networks,
present
promising
avenue
in
biomedical
applications
due
to
their
close
resemblance
natural
tissues.
However,
mechanical
performance
often
falls
short,
limiting
clinical
applications.
Recent
research
has
been
focused
on
developing
hydrogel
therapeutic
advancements
have
spurred
researchers
develop
hydrogels
having
acceptable
toughness.
While
it
is
now
possible
tailor
properties
synthetic
gels
mimic
those
tissues,
critical
aspects
such
as
biocompatibility
crosslinking
strategies
are
frequently
neglected.
This
review
scrutinizes
structural
techniques
designed
improve
toughness
hydrogels,
focusing
especially
innovative
efforts
integrate
these
enhancements
into
natural-based
hydrogels.
By
thoroughly
examining
methodologies,
sheds
light
complexities
strengthening
will
propose
valuable
insights
development
next-generation
tissue
substitutes.
