Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 22, 2024
Pesticides
and
pharmaceuticals
enter
aquatic
ecosystems
as
complex
mixtures.
Various
processes
govern
their
dissipation
effect
on
the
sediment
surface
waters.
These
micropollutants
often
show
persistence
can
adversely
affect
microorganisms
even
at
low
concentrations.
We
investigated
effects
procaryotic
communities
of
metformin
(antidiabetic
drug),
metolachlor
(agricultural
herbicide),
terbutryn
(herbicide
in
building
materials).
contaminants
were
introduced
individually
or
a
mixture
(17.6
µM
per
micropollutant)
into
laboratory
microcosms
mimicking
sediment-water
interface.
Metformin
completely
dissipated
within
70
days,
whereas
persisted.
Dissipation
did
not
differ
whether
part
mixture.
Sequence
analysis
16S
rRNA
gene
amplicons
evidenced
distinct
responses
prokaryotic
both
water.
Prokaryotic
community
variations
mainly
driven
by
matrix
composition
incubation
time.
Micropollutant
exposure
played
secondary
but
influential
role,
with
pronounced
recalcitrant
micropollutant
Antagonistic
synergistic
non-additive
identified
for
specific
taxa
across
taxonomic
levels
response
to
This
study
underscores
importance
considering
diversity
interactions
between
micropollutants,
communities,
respective
environments
when
examining
interfaces
affected
multiple
contaminants.
Metformin
has
been
widely
detected
in
aquatic
ecosystems,
yet
the
knowledge
of
its
impact
on
organisms,
particularly
at
environmentally
relevant
concentrations,
remains
limited.
In
present
study,
we
characterized
developmental
toxicity
metformin
zebrafish,
utilizing
a
transcriptome-guided
toxicological
assessment
framework.
Transcriptomic
analysis
conducted
concentrations
within
μg/L
range
revealed
significant
disruptions
biological
processes
associated
with
nucleotide,
hydrocarbon,
and
amino
acid
metabolism,
suggesting
disturbance
energy
homeostasis.
This
observation
was
corroborated
by
energy-targeted
metabolomic
analysis,
wherein
considerable
number
metabolites
involved
purine
pyrimidine
citrate
cycle
displayed
alterations.
Notably,
most
intermediates
such
as
acetyl-CoA
exhibited
remarkable
decreases.
Additionally,
our
study
identified
impediments
zebrafish
embryonic
development,
including
decreased
yolk
extension
progress,
spontaneous
contraction
body
length,
increased
sac
area
yolk/while
lipid
content
ratio,
low
0.12
μg/L.
Furthermore,
disruption
homeostasis
observed
to
persist
into
adulthood
even
after
prolonged
recovery
period.
The
findings
highlighted
disruptive
effects
development
teleost
thereby
prompting
reevaluation
environmental
risk
nontarget
organisms.
Environmental Science & Technology,
Journal Year:
2025,
Volume and Issue:
59(5), P. 2765 - 2777
Published: Jan. 31, 2025
Large-scale
water
diversion
projects
are
essential
for
meeting
the
needs
of
water-stressed
regions,
necessitating
an
evaluation
their
impact
on
quality
and
aquatic
ecosystems.
This
study
provides
first
snapshots
organic
micropollutants
(OMPs)
along
1466
km
Eastern
Route
China's
South-to-North
Water
Diversion
Project.
Using
nontarget
analysis
with
ultrahigh-performance
liquid
chromatography
high-resolution
mass
spectrometry,
we
identified
quantified
357
OMPs
from
samples
collected
during
period
(WDP)
nonwater
(NWDP).
The
included
136
household
compounds,
112
agricultural
102
industrial
7
traffic
markers.
Significant
regional
variations
in
OMP
concentrations
compositions
were
observed
NWDP
due
to
diverse
local
pollution
sources
route.
However,
such
differences
reduced
WDP,
likely
transfer.
diversity
varied
substantially
but
was
more
stable
less
distance
decay
WDP.
Network
indicated
closer
relationships
between
suggesting
a
consistent
spatial
distribution.
source
overwhelmingly
influenced
These
findings
underscore
need
ongoing
assessments
Toxics,
Journal Year:
2025,
Volume and Issue:
13(4), P. 310 - 310
Published: April 16, 2025
Metformin
disinfection
byproducts
Y
and
C
have
emerged
as
pollutants
of
concern
in
drinking
water
systems
are
suspected
to
possess
significant
toxicity
mammals.
However,
effective
strategies
mitigate
the
effects
exposure
mammals
not
been
thoroughly
formulated.
This
study
aimed
investigate
characteristic
phenotypes
short-term,
high-dose
intestine
liver
mice
evaluate
protective
Dictyophora
rubrovolvata
extract
(DRE)
on
Y-
C-induced
intestinal
damage.
The
results
showed
that
exposure-induced
manifested
mainly
barrier
dysfunction,
induction
immune
response
oxidative
stress,
disruption
flora
homeostasis.
Hepatotoxicity
was
characterized
by
histopathological
changes
such
vacuolar
degeneration,
abnormal
function,
stress.
Additionally,
marked
gut
microbiota
biochemical
indicators
were
closely
related
hepatic
injuries
after
exposure.
DRE
effectively
alleviated
damage,
reshaped
microbiota,
maintained
gut–liver
axis
These
findings
provide
new
insights
into
toxic
byproduct
through
gut-liver
suggest
functional
food
extracts
may
serve
protect
against
these
adverse
health
outcomes.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 20, 2024
The
biguanide
drug
metformin
is
a
first-line
blood
glucose-lowering
medication
for
type
2
diabetes,
leading
to
its
presence
in
the
global
environment.
However,
little
known
about
fate
of
by
microbial
catabolism.
Here,
we
characterize
Ni
Environmental Science and Pollution Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
The
concentrations
of
135
pharmaceuticals
and
personal
care
products
(PPCPs)
were
determined
in
raw
influent,
final
effluent,
treated
biosolids
at
Canadian
wastewater
treatment
plants
(WWTPs)
to
evaluate
the
fate
PPCPs
through
liquid
solids
trains
typical
types
used
Canada
assess
changes
PPCP
matrices
between
2010-2013
2022.
dominant
influent
effluent
included
antidiabetic
metformin,
analgesics/anti-inflammatories
(acetaminophen,
ibuprofen,
2-hydroxy-ibuprofen),
caffeine
its
metabolite
(1,7
-
dimethylxanthine),
theophylline
(a
bronchodilator
caffeine),
an
insect
repellent
(N,N-diethyl-m-toluamide,
DEET),
iopamidol
contrast
media
for
X-rays).
differed
from
those
influent/effluent
antibiotics
(fluoroquinolones
doxycycline),
antidepressants
(sertraline,
citalopram,
amitriptyline),
a
preservative
antimicrobial
agent
(triclosan),
antihistamine
(diphenhydramine),
antifungal
(clotrimazole).
These
elevated
reflected
their
use
communities.
had
relatively
low
hydrophobicity
whereas
tended
be
more
hydrophobic,
or
electrostatic
forces
governed
sorption.
Higher
removal
was
generally
observed
WWTPs
that
biological
compared
primary
physical/chemical
treatment.
concentration
2022
influenced
by
risk
management
measures,
warnings,
development
new
pharmaceuticals,
COVID-19
pandemic,
other
factors.
time
trends
limited
information
available
on
Canada.
Continued
periodic
monitoring
is
recommended
fill
data
gaps
community
release
environment.
Environmental Science and Pollution Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
The
growing
introduction
of
pharmaceutical
compounds
into
waterways
is
a
contemporary
environmental
issue
in
the
Middle
East
and
North
Africa.
This
escalating
problem
necessitates
careful
examination
risks
associated
with
presence
pharmaceuticals
water
sources.
present
study
analysed
samples
from
eight
wastewater
treatment
plants
an
Arabian
Peninsula
nation.
Sixty-nine
percent
were
partially
or
fully
removed,
while
31%
showed
higher
effluent
concentrations,
indicating
potential
accumulation
post-treatment.
highest
detected
paracetamol
(1300
±
8
ng/L),
metformin
(1100
70
ng/L)
effluent,
mefenamic
acid
(630
3
captopril
(560
11
amitriptyline
(510
1
influents.
For
radiopharmaceuticals,
influent
activity
exceeded
that
effluents,
Ga-67
being
most
prominent
(influent,
0.28
0.07
Bq/L;
0.22
0.02
Bq/L).
Sludge
radioactivity
levels
than
samples,
primarily
I-131
at
5
2
Bq/kg.
data
obtained
this
will
enable
assessment
hazards
posed
by
mixtures
receiving
environment
hitherto
less
studied
region.
