Embryonic Exposure to the Benzotriazole Ultraviolet Stabilizer 2‐(2H‐benzotriazol‐2‐yl)‐4‐methylphenol Decreases Fertility of Adult Zebrafish (Danio rerio)

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 43(2), P. 385 - 397

Published: Nov. 17, 2023

Benzotriazole ultraviolet stabilizers (BUVSs) are emerging contaminants of concern. They added to a variety products, including building materials, personal care paints, and plastics, prevent degradation caused by (UV) light. Despite widespread occurrence in aquatic environments, little is known regarding the effects BUVSs on organisms. The aim present study was characterize exposure 2-(2H-benzotriazol-2-yl)-4-methylphenol (UV-P) reproductive success zebrafish (Danio rerio) following embryonic exposure. Embryos were exposed, use microinjection, UV-P at <1.5 (control), 2.77, 24.25 ng/g egg, reared until sexual maturity, when performance assessed, which molecular biochemical endpoints analyzed. Exposure did not have significant effect fecundity. However, there fertilization success. Using UV-P-exposed males females, fertility decreased 8.75% low treatment group 15.02% high relative control. In reproduction assay with control 11.47% Embryonic might perturbed male sex steroid synthesis as indicated small changes blood plasma concentrations 17β-estradiol 11-ketotestosterone, statistically nonsignificant decreases mRNA abundances cyp19a1a, cyp11c1, hsd17b3. addition, transcript genes involved spermatogenesis, such nanos2 dazl, observed. Decreases later stages sperm development observed, suggesting that impaired spematogenesis, resulting quantity. first demonstrate latent BUVSs, specifically fish reproduction. Environ Toxicol Chem 2024;43:385-397. © 2023 Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC behalf SETAC.

Language: Английский

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Degradation of Uv328 by Ozone/Peroxymonosulfate System: Performance and Mechanisms

Published: Jan. 1, 2024

Language: Английский

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Evaluating the embryotoxicity of benzophenone-based photoinitiators in stem cells and zebrafish embryos

Toxicology, Journal Year: 2024, Volume and Issue: 508, P. 153930 - 153930

Published: Aug. 17, 2024

Benzophenones (BPs) are widely used as photoinitiators (PIs) or printing inks in food packaging, which may migrate into foods. However, the toxicity information of some BP analogues, such 4,4'-bis(diethylamino)-benzophenone (DEAB), 4-phenylbenzophenone (4-PBP), 4 (hydroxymethyl)benzophenone (4-HMBP), those PIs is lacking. Developmental a health concern associated with exposure. Recently, alternative non-in vivo methods have been proposed to evaluate concerned chemicals better understand modes action certain toxicological endpoints. In this study, using silico methods, we predicted that BP, DEAB, 4-PBP and 4-HMBP might exhibit developmental toxicity. found only DEAB strong embryotoxic disturbs early differentiation mouse embryonic stem cells three germ layers cardiomyocytes. treatment also prevented cardiomyocyte human induced pluripotent (hiPSCs) on day 10. had no similar effects Transcriptomic analysis revealed significantly decreased mRNA levels differentiation-related transcription factors SOX17 FOXA1, hiPSCs 4. Furthermore, caused tail malformations yolk sac edema zebrafish embryos. To conclude, be because it cells. Further studies warranted

Language: Английский

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Elevated Levels of Photoinitiators in Nail Salon Workers’ Hand Wipes and Occupational Risk Estimation

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(10), P. 1082 - 1089

Published: Sept. 4, 2024

Language: Английский

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Decision: Monitoring to conservation: The science–policy nexus of plastics and seabirds — R0/PR4

Published: April 17, 2023

Seabirds have been the messengers of marine plastics pollution since 1950s, not long after began to be commercially manufactured. In decades since, a number multilateral agreements emerged address that informed by research and monitoring on plastic ingestion in seabirds. continue serve as effective monitors for oceans, increasingly chemical contamination from environment additives chemicals can adsorb accumulate seabirds' tissues. Plastics has far-reaching ecological impacts, but motivation addressing issue escalated rapidly at international level. are also most globally threatened group birds require concerted conservation actions mitigate population declines multiple pressures. However, policy mechanisms focus mitigation anthropogenically induced stressors, using seabird data, often fail include conserve messengers. this review, we discuss how impacts seabirds is used inform highlight competing interests emerge approach. Finally, opportunities ensure indicators ocean health simultaneously achieve goals.

Language: Английский

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