Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
259, P. 115039 - 115039
Published: May 24, 2023
Growing
evidence
links
long-term
air
pollution
exposure
with
renal
function.
However,
little
research
has
been
conducted
on
the
combined
effects
of
pollutant
mixture
function
and
multiple
mediation
metabolic
risk
factors.
This
study
enrolled
8996
adults
without
chronic
kidney
disease
(CKD)
at
baseline
from
CHCN-BTH
cohort
study.
Three-year
to
pollutants
[particulate
matter
≤
2.5
µm
(PM2.5),
PM10,
PM1,
ozone
(O3),
nitrogen
dioxide
(NO2),
sulfur
(SO2)
carbon
monoxide
(CO)]
PM2.5
components
[black
(BC),
ammonium
(NH4+),
nitrate
(NO3-),
sulfate
(SO42-)
organic
(OM)]
were
assessed
using
well-validated
machine
learning
methods.
Linear
mixed
models
applied
investigate
associations
between
estimated
glomerular
filtration
rate
(eGFR).
Quantile
G-computation
was
used
assess
mixtures.
Causal
analysis
Bayesian
employed
estimate
An
interquartile
range
increases
in
BC
(-0.256,
95
%CI:
-0.331,
-0.180)
OM
(-0.603,
-0.810,
-0.397)
significantly
associated
eGFR
decline;
while
O3
(1.151,
0.813,
1.489),
PM10
(0.721,
0.309,
1.133),
NH4+
(0.990,
0.638,
1.342),
NO3-
(0.610,
0.405,
0.815)
higher
eGFR.
The
effect
component
found
be
lower
(-1.147,
%
CI:
-1.456,
-0.839),
contributing
72.4
negative
effect.
Univariate
analyses
showed
that
high-density
lipoprotein
(HDL)
mediated
7.1
%,
6.9
6.1
O3,
BC,
OM,
respectively.
these
not
significant
analysis.
These
findings
suggest
decline
strong
contribution
OM.
Metabolic
factors
may
mediate
pollutants.
Further
is
warranted
clarify
potential
mechanisms
involved.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(20), P. 8675 - 8684
Published: May 10, 2024
Pregnant
women
are
physiologically
prone
to
glucose
intolerance,
while
the
puerperium
represents
a
critical
phase
for
recovery.
However,
how
air
pollution
disrupts
homeostasis
during
gestational
and
early
postpartum
periods
remains
unclear.
This
prospective
cohort
study
conducted
an
oral
tolerance
test
measured
insulin
levels
of
834
pregnant
in
Guangzhou,
with
follow-up
443
puerperae
at
6-8
weeks
postpartum.
Residential
PM
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
259, P. 115039 - 115039
Published: May 24, 2023
Growing
evidence
links
long-term
air
pollution
exposure
with
renal
function.
However,
little
research
has
been
conducted
on
the
combined
effects
of
pollutant
mixture
function
and
multiple
mediation
metabolic
risk
factors.
This
study
enrolled
8996
adults
without
chronic
kidney
disease
(CKD)
at
baseline
from
CHCN-BTH
cohort
study.
Three-year
to
pollutants
[particulate
matter
≤
2.5
µm
(PM2.5),
PM10,
PM1,
ozone
(O3),
nitrogen
dioxide
(NO2),
sulfur
(SO2)
carbon
monoxide
(CO)]
PM2.5
components
[black
(BC),
ammonium
(NH4+),
nitrate
(NO3-),
sulfate
(SO42-)
organic
(OM)]
were
assessed
using
well-validated
machine
learning
methods.
Linear
mixed
models
applied
investigate
associations
between
estimated
glomerular
filtration
rate
(eGFR).
Quantile
G-computation
was
used
assess
mixtures.
Causal
analysis
Bayesian
employed
estimate
An
interquartile
range
increases
in
BC
(-0.256,
95
%CI:
-0.331,
-0.180)
OM
(-0.603,
-0.810,
-0.397)
significantly
associated
eGFR
decline;
while
O3
(1.151,
0.813,
1.489),
PM10
(0.721,
0.309,
1.133),
NH4+
(0.990,
0.638,
1.342),
NO3-
(0.610,
0.405,
0.815)
higher
eGFR.
The
effect
component
found
be
lower
(-1.147,
%
CI:
-1.456,
-0.839),
contributing
72.4
negative
effect.
Univariate
analyses
showed
that
high-density
lipoprotein
(HDL)
mediated
7.1
%,
6.9
6.1
O3,
BC,
OM,
respectively.
these
not
significant
analysis.
These
findings
suggest
decline
strong
contribution
OM.
Metabolic
factors
may
mediate
pollutants.
Further
is
warranted
clarify
potential
mechanisms
involved.
