Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(44)
Published: Oct. 7, 2024
Abstract
The
treatment
of
infected
bone
defects
(IBDs)
needs
simultaneous
elimination
infection
and
acceleration
regeneration.
One
mechanism
that
hinders
the
regeneration
IBDs
is
iron
competition
between
pathogens
host
cells,
leading
to
an
deficient
microenvironment
impairs
innate
immune
responses.
In
this
work,
in
situ
modification
strategy
proposed
for
printing
iron‐active
multifunctional
scaffolds
with
homeostasis
regulation
ability
treating
IBDs.
As
a
proof‐of‐concept,
ultralong
hydroxyapatite
(HA)
nanowires
are
modified
through
growth
layer
gallate
(FeGA)
followed
by
incorporation
poly(lactic‐co‐glycolic
acid)
(PLGA)
matrix
print
biomimetic
PLGA
based
composite
containing
FeGA
HA
(FeGA‐HA@PLGA).
photothermal
effect
endows
excellent
antibacterial
activity.
released
ions
from
FeGA‐HA@PLGA
help
restore
microenvironment,
thereby
promoting
anti‐inflammatory,
angiogenesis
osteogenic
differentiation.
transcriptomic
analysis
shows
exert
anti‐inflammatory
pro‐osteogenic
differentiation
activating
NF‐κB,
MAPK
PI3K‐AKT
signaling
pathways.
Animal
experiments
confirm
repair
performance
IBDs,
suggesting
promising
prospect
therapy
future
clinical
applications.
Global Change Biology,
Journal Year:
2024,
Volume and Issue:
30(7)
Published: July 1, 2024
Abstract
Microplastic
(MP)
pollution
likely
affects
global
soil
carbon
(C)
dynamics,
yet
it
remains
uncertain
how
and
to
what
extent
MP
influences
respiration.
Here,
we
report
on
a
meta‐analysis
determine
the
effects
of
microbiome
CO
2
emission.
We
found
that
significantly
increased
contents
organic
C
(SOC)
(21%)
dissolved
(DOC)
(12%),
activity
fluorescein
diacetate
hydrolase
(FDAse)
(10%),
microbial
biomass
(17%),
but
led
decrease
in
diversity
(3%).
In
particular,
increases
components
further
promote
emission
(25%)
from
soil,
with
much
higher
effect
MPs
these
emissions
than
biomass.
The
could
be
attributed
opposite
vs.
diversity,
as
accumulation
recruited
some
functionally
important
bacteria
provided
additional
substrates
for
specific
heterotrophic
microorganisms,
while
inhibiting
growth
autotrophic
taxa
(e.g.,
Chloroflexi
,
Cyanobacteria
).
This
study
reveals
can
increase
by
causing
shifts
microbiome.
These
results
underscore
potential
importance
plastic
terrestrial
fluxes,
thus
climate
feedbacks.
Eco-Environment & Health,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100136 - 100136
Published: Jan. 1, 2025
Microplastics
(MPs)
and
antibiotic
resistance
genes
(ARGs)
pose
significant
challenges
to
the
One
Health
framework
due
their
intricate
multifaceted
ecological
environmental
impacts.
However,
understanding
of
how
MP
properties
influence
ARG
prevalence
in
mariculture
sediments
remains
limited.
Herein,
polystyrene
(PS)
polyvinyl
chloride
(PVC)
MPs
with
different
sizes
(20-120
μm
0.5-2.0
mm)
were
selected
evaluate
impacts
underlying
mechanisms
driving
ARGs
dissemination.
The
results
showed
that
PS
PVC
increased
relative
abundance
by
1.41-2.50-fold
2.01-2.84-fold,
respectively,
compared
control,
particularly
high-risk
genes.
polymer
type
effect
was
identified
as
more
influential
than
size
sediment
resistome
evolution.
shifted
microbial
community
assembly
from
stochastic
deterministic
processes,
thus
enriching
host
pathogens.
Furthermore,
highly
hydrophobic
not
only
recruited
bacteria
colonization
but
also
facilitated
exchange
within
plastisphere.
exogenous
additives
released
(e.g.,
heavy
metals,
bisphenol
A,
tridecyl
ester)
particles
synergistically
promoted
conjugative
transfer
inducing
oxidative
stress
enhancing
cell
membrane
permeability.
These
findings
revealed
characteristics
spread
marine
benthic
ecosystems,
underscoring
importance
mitigating
pollution
maintain
ecosystem
health,
prevent
zoonotic
diseases,
balance
global
health.
Water Research,
Journal Year:
2025,
Volume and Issue:
274, P. 123092 - 123092
Published: Jan. 4, 2025
Chlorine,
the
most
widely
utilized
disinfectant
for
drinking
water
globally,
has
recently
been
implicated
in
facilitating
spread
of
antibiotic
resistance
genes
(ARGs),
raising
concerns
about
its
underestimated
environmental
and
ecological
risks.
However,
given
current
fragmented
research
focus
results,
a
comprehensive
understanding
potential
mechanisms
influencing
factors
behind
chlorination-promoted
ARGs
transmission
systems
is
crucial.
This
work
first
to
systematically
review
variations
abundance,
mechanisms,
factors,
mitigation
strategies
related
during
chlorination
process.
The
results
indicated
that
could
induce
genetic
mutations
promote
horizontal
gene
transfer
through
multiple
pathways,
including
increased
reactive
oxygen
species,
enhanced
membrane
permeability,
stimulation
SOS
response,
activation
efflux
pumps.
In
addition,
this
delves
into
significant
discoveries
regarding
affecting
ARG
water,
such
as
chlorine
concentration,
reaction
time,
disinfection
byproducts,
pipe
materials,
biofilms,
matrix.
A
series
effective
from
source
point-of-use
were
proposed
aimed
at
mitigating
risks
system.
Finally,
we
address
existing
challenges
outline
future
directions
overcome
these
bottlenecks.
Overall,
aims
advance
our
role
dissemination
inspire
innovative
ideas
optimizing
techniques,
minimizing
transmission,
enhancing
safety
water.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(33), P. 12137 - 12152
Published: Aug. 14, 2023
Microorganisms
colonizing
the
surfaces
of
microplastics
form
a
plastisphere
in
environment,
which
captures
miscellaneous
substances.
The
plastisphere,
owning
to
its
inherently
complex
nature,
may
serve
as
"Petri
dish"
for
development
and
dissemination
antibiotic
resistance
genes
(ARGs),
adding
layer
complexity
tackling
global
challenge
both
ARGs.
Increasing
studies
have
drawn
insights
into
extent
proliferation
ARGs
occurred
presence
micro/nanoplastics,
thereby
increasing
antimicrobial
(AMR).
However,
comprehensive
review
is
still
lacking
consideration
current
increasingly
scattered
research
focus
results.
This
focuses
on
spread
mediated
by
microplastics,
especially
challenges
perspectives
determining
contribution
AMR.
accumulates
biotic
abiotic
materials
persistent
surfaces,
which,
turn,
offers
preferred
environment
gene
exchange
within
across
boundary
plastisphere.
Microplastics
breaking
down
smaller
sizes,
such
nanoscale,
can
possibly
promote
horizontal
transfer
environmental
stressors
inducing
overgeneration
reactive
oxygen
species.
Additionally,
we
also
discussed
methods,
quantitatively
comparing
ARG
profiles
among
different
samples
this
emerging
field
that
multidimensional
parameters
are
great
necessity
systematically
determine
risk
Finally,
based
biological
sequencing
data,
offered
framework
assess
AMR
risks
micro/nanoplastics
biocolonizable
microparticles
leverage
AMR-associated
messages,
including
ARGs'
abundance,
mobility,
potential
acquisition
pathogens.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(17), P. 7291 - 7301
Published: April 16, 2024
The
environmental
dissemination
of
extracellular
antibiotic
resistance
genes
(eARGs)
in
wastewater
and
natural
water
bodies
has
aroused
growing
ecological
concerns.
coexisting
chemical
pollutants
are
known
to
markedly
affect
the
eARGs
transfer
behaviors
microbial
community,
but
detailed
interactions
specific
impacts
remain
elusive
so
far.
Here,
we
revealed
a
concentration-dependent
impact
dimethyl
phthalate
(DMP)
several
other
types
esters
(common
released
from
plastics)
on
transformation
eARGs.
DMP
exposure
at
an
environmentally
relevant
concentration
(10
μg/L)
resulted
4.8-times
raised
frequency
Acinetobacter
baylyi
severely
suppressed
high
(1000
μg/L).
promotion
by
low-concentration
was
attributed
multiple
mechanisms,
including
increased
bacterial
mobility
membrane
permeability
facilitate
uptake
improved
DMP-bounded
(via
noncovalent
interaction)
enzymatic
degradation
(with
DNase
activity).
Similar
promoting
effects
were
also
found
real
biofilm
systems.
In
contrast,
higher-concentration
disrupting
DNA
structure.
Our
findings
highlight
potentially
underestimated
spreading
aquatic
environments
due
deepen
our
understanding
risks
biological-chemical
combined
pollution
bodies.
