Ecological criteria for antibiotics in aquatic environments based on species sensitivity distribution

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 287, P. 117261 - 117261

Published: Oct. 31, 2024

Due to the substantial production and use of antibiotics, they inevitably remain in aquatic environments, posing a serious threat ecosystems. However, there are currently no criteria antibiotics for ecological risk water environment. In present study, three types (tetracyclines, sulfonamides quinolones) that often detected environments were investigated. Toxicity data regarding bacteria, algae, plants, invertebrates vertebrates selected, species sensitivity distribution was used obtain organisms. Animals least sensitive antibiotics. The overall toxicity is most bacteria cyanobacteria, followed by green algae plants. recommended tetracyclines, quinolones, 22, 17, 94 μg/L, respectively. Ofloxacin needs be with caution because it has small acute predicted no-effect concentration (PNEC) 0.6 μg/L. criterion chronic total determined 1.4 PNECs measured quinolone, tetracycline, sulfonamide 0.5, 2.2, 2.4 Norfloxacin had highest zone 353, indicating poisoning likely occur. Moreover, an exponential correlation between PNEC PNEC. addition, quantitative structure-activity relationship model constructed These findings can expand threshold on effects organisms, provide theoretical basis environmental assessment

Language: Английский

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Slow-Release Pharmaceutical Implants in Ecotoxicology: Validating Functionality across Exposure Scenarios

ACS Environmental Au, Journal Year: 2024, Volume and Issue: 5(1), P. 69 - 75

Published: Nov. 25, 2024

Pharmaceutical contaminants have spread in natural environments across the globe, endangering biodiversity, ecosystem functioning, and public health. Research on environmental impacts of pharmaceuticals is growing rapidly, although a majority studies are still conducted under controlled laboratory conditions. As such, there an urgent need to understand pharmaceutical exposures wildlife complex, real-world scenarios. Here, we validate performance slow-release implants-a recently developed tool field-based ecotoxicology that allows for chemical dosing free-roaming aquatic species-in terms accumulation distribution interest tissues. Across two years, directly exposed 256 Atlantic salmon (Salmo salar) smolts one four treatments: clobazam (50 μg g-1 implant), tramadol g-1), each), control (0 g-1). Fish dosed with implants containing or tramadol, their mixture, accumulated these all sampled tissues: brain, liver, muscle. Concentrations both peaked tissues at 1 day post-implantation, before reaching relatively stable, slowly declining concentrations remainder 30-day sampling period. Generally, highest were detected followed by brain then muscle, observed each being higher single-exposure treatments relative mixture exposure. Taken together, our findings underscore utility as ecotoxicology, which research priority given current lack knowledge wildlife.

Language: Английский

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Synergistic interactions of zeolite, stocking density, and water exchange: A holistic approach to optimizing aquaculture performance of juvenile European seabass (Dicentrarchus labrax)

Scientific African, Journal Year: 2023, Volume and Issue: 23, P. e02043 - e02043

Published: Dec. 21, 2023

Effective water management is an essential component of sustainable fish farming practices, particularly in the context global scarcity. The accumulation ammonium ions (NH4+) from metabolism necessitates frequent changes, posing a challenge to sustainability operations. Zeolite materials have emerged as promising solution, offering enhanced cation removal compared conventional nitrifying bacteria. This innovative approach alleviates pressure on resources and promotes environmental farming. Over 75 days, this study examined how zeolite, stocking density, exchange affected European seabass quality growth. 250 kg seabass, 25.61±2.39 g/fish. Three factors: zeolite levels (Z: 0, 10, 15 ppt), density (D: 1, 2.5, 5 kg/m3), (W: 10%, 25%, 50%), using 81 hapas with 0.5 m3 volume each (triplicates for treatment) fixed concrete ponds, were randomly distributed among experimental 27 ponds. research illuminates potential benefits various therapies. culture improved quality. It reduced ammonia derivatives, improving Adjusting low or high measures. change kept dissolved oxygen within target range, providing good home farmed fish. supplements, optimum growth, along improvements. These interventions feed consumption growth rates. approaches promoted stress by limiting negative effects density. also immune-related, hematobiochemical, plasma biochemical characteristics after interventions. supplementation, these characteristics. They strengthened seabass' immune system preserved healthy hematobiochemical parameters. In conclusion, optimizing (15 (1 (50%) enhances quality, performance, physiological contributes aquaculture efficiency. Further required fully elucidate molecular mechanisms those factors that affect health practices.

Language: Английский

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Exposure Effects of Environmentally Relevant Concentrations of the Tricyclic Antidepressant Amitriptyline in Early Life Stage Zebrafish

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Antidepressants are one of the most globally prescribed classes pharmaceuticals, and drug target conservation across phyla means that nontarget organisms may be at risk from effects exposure. Here, we address knowledge gap for chronic exposure (28 days) to tricyclic antidepressant amitriptyline (AMI) on fish, including concentrations with environmental relevance, using zebrafish (Danio rerio) as our experimental model. AMI was found bioconcentrate in zebrafish, readily transformed its major active metabolite nortriptyline, induced a pharmacological effect (downregulation gene encoding serotonin transporter; slc6a4a) environmentally relevant (0.03 μg/L above). Exposures higher accelerated hatch rate reduced locomotor activity, latter which abolished after 14 day period depuration. The lack any response features physiology behavior measured environment would indicate poses relatively low level fish populations. pseudopersistence likely presence multiple drugs acting via same mechanism action, however, together global trend increased prescription rates, mean this underestimated current ecotoxicological assessment paradigms.

Language: Английский

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Pharmacokinetics, optimal dosages and withdrawal time of amoxicillin in Nile tilapia ( Oreochromis niloticus ) reared at 25 and 30 °C

Veterinary Quarterly, Journal Year: 2024, Volume and Issue: 44(1), P. 1 - 9

Published: Aug. 27, 2024

Knowledge of amoxicillin (AMX) pharmacokinetics (PK) and tissue residues in fish, which is necessary for prudent drug use, remains limited. The study aimed to explore the PK characteristics AMX Nile tilapia (

Language: Английский

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