The
deleterious
health
implications
of
perfluoroalkyl
and
polyfluoroalkyl
substances
(PFAS)
are
widely
recognized.
Females,
in
contrast
to
males,
exhibit
unique
pathways
for
PFAS
exposure
excretion,
leading
complex
outcomes.
status
females
is
largely
influenced
by
hormone-related
processes.
have
been
reported
be
associated
with
various
aspects
female
health,
including
reproductive
system
disorders
pregnancy-related
diseases.
In
this
article,
we
provide
insights
into
the
correlations
between
female-prevalent
Current
epidemiological
toxicological
evidence
has
demonstrated
that
adverse
effects
on
primarily
attributed
disruption
hypothalamic-pituitary-gonadal
(HPG)
axis
hormonal
homeostasis.
However,
these
findings
do
not
sufficiently
elucidate
intricate
associations
specific
Furthermore,
autoimmune
disorders,
another
category
more
prevalent
women
compared
men,
require
additional
investigation.
Immune
biomarkers
pertinent
observed
exposure,
although
insufficient
substantiate
relations.
Further
thorough
exploration
encompassing
studies
essential
elucidating
inherent
influence
human
pathologies.
Additionally,
comprehensive
investigations
issues
beyond
their
functions
essential.
TrAC Trends in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
173, P. 117653 - 117653
Published: March 12, 2024
This
review
describes
a
wide
variety
of
analytical
approaches
for
the
assessment
human
exposure
to
organic
chemicals
associated
with
plastic
additives,
focusing
on
works
published
in
last
decade
plasticisers,
bisphenols,
flame
retardants
and
antioxidants.
Physiologically
based
extraction
tests
serve
as
preliminary
in-vitro
assays
determine
bioaccessibility
these
compounds
from
micro/nanoplastics
body
fluids
gastrointestinal
tract,
skin,
or
lung.
Whenever
plastic-laden
become
bioavailable,
metabolism
is
be
monitored
through
phase
I
II
metabolites.
In
this
regard,
methods
chromatography
mass
spectrometry
biomonitoring
parent
their
metabolites
biological
samples
(mostly
urine
plasma)
are
discussed
depth.
also
covers
role
wastewater-based
epidemiology
determining
overall
given
population
plastic-related
species.
Although
epidemiological
studies
have
explored
the
association
between
poly-
and
perfluoroalkyl
substances
(PFAS)
concentrations
semen
quality,
existing
findings
are
often
inconsistent.
Our
work
aimed
to
explore
of
PFAS
in
plasma
with
repeated
measures
quality
parameters
healthy
adults.
Plasma
was
collected
at
initial
recruitment
least
once
within
five
predetermined
intervals
during
an
approximately
3-month
period.
Semen
volume,
concentration,
motility,
total
sperm
count
were
measured
each
specimen.
individual
samples
(n
=
1252)
pooled
1019)
from
multiple
collections
(or
a
single
sample
if
no
collection
available).
The
results
reveal
seminal
perfluorooctanoic
acid,
perfluorooctanesulfonic
perfluorohexanesulfonic
6:2
chlorinated
polyfluoroalkyl
ether
sulfonate
significantly
associated
decreased
progressive
motility
while
positively
concentration
count.
By
contrast,
null
associations
observed
quality.
study
provides
evidence
that
exposure
may
affect
male
fertility
should
be
for
precise
assessment
impact
on
reproductive
performances.
The
human
exposome
remains
limited
due
to
the
challenging
analytical
strategies
used
reveal
low-level
endocrine-disrupting
chemicals
(EDCs)
and
their
metabolites
in
serum
urine.
This
limits
integrity
of
EDC
exposure
assessment
hinders
understanding
cumulative
health
effects.
In
this
study,
we
propose
an
enhanced
protocol
based
on
multi-solid-phase
extraction
(multi-SPE)
expand
with
polar
EDCs
train
a
machine
learning
(ML)
model
for
methodology
prediction
molecular
descriptors.
measurement
70
(25%)
34
(12%)
out
295
well-acknowledged
urine
compared
hydrophilic–lipophilic
balance
sorbent
alone.
nontarget
analysis
from
20
women
childbearing
age
cohort
498,
controlling
occupational
factors
daily
behaviors
high
chemical
potential,
multi-SPE
increased
10
(40%)
16
(53%)
target
identification
17
(77%)
(36%)
(confidence
≥
level
3)
urine,
respectively.
Interestingly,
ML
predicted
that
could
identify
additional
38%
most
bioactive
chemicals.
conclusion,
advances
by
expanding
profiles.
Chinese Journal of Chromatography,
Journal Year:
2025,
Volume and Issue:
43(1), P. 13 - 21
Published: Jan. 1, 2025
Industrialization
has
led
to
significant
increases
in
the
types
and
quantities
of
pollutants,
with
environmental
pollutants
widely
present
various
media,
including
air,
food,
everyday
items.
These
can
enter
human
body
via
multiple
pathways,
ingestion
through
food
absorption
skin;
this
intrusion
disrupt
production,
release,
circulation
hormones
body,
resulting
a
range
illnesses
that
affect
reproductive,
endocrine,
nervous
systems.
Consequently,
these
pose
substantial
risks
health.
In
particular,
fetuses
are
highly
sensitive
during
critical
stages
development,
exposure
periods
growth
development
result
more-obvious
severe
health
hazards
lead
preterm
birth,
low
birth
weight,
fetal
malformations.
The
placenta
acts
as
barrier
between
mother
fetus,
selectively
filters
certain
pollutants.
While
some
remain
maternal
bloodstream,
others
cross
placental
into
umbilical
blood
passive
diffusion,
transport
proteins,
or
endocytosis.
transplacental
transfer
efficiency
(TTE)
is
ratio
level
pollutant
blood,
valuable
metric
for
evaluating
ability
breach
barrier.
A
higher
TTE
implies
larger
proportion
transferred
from
thereby
amplifying
potential
fetus.
Mass
spectrometry-based
detection
methods
extensively
used
chemical
sciences
because
they
exceptionally
resolving.
This
analytical
technique
involves
ionizing
compounds
within
sample
identifying
them
based
on
their
distinct
mass-to-charge
ratios;
it
enables
both
qualitative
quantitative
analyses
Current
methodologies
examining
include
in-vitro
experiments,
animal
studies,
epidemiologic
model
calculation;
approaches
help
evaluate
fetus
placenta.
Analyzing
TTEs
different
chemicals
high-risk
be
identified
provides
an
understanding
abilities
Research
focused
mainly
per-
polyfluoroalkyl
substances
(PFASs),
polybrominated
diphenyl
ethers
(PBDEs),
polychlorinated
biphenyls
(PCBs),
organochlorine
pesticides
(OCPs),
relatively
few
studies
other
reported.
Pollutant
complex
process
influenced
by
factors
physical
properties
(e.g.,
molecular
mass,
solubility,
lipophilicity),
lifestyle,
genetics,
conditions,
socioeconomic
status),
characteristics
maturity,
flow,
metabolic
enzymes).
review
summarizes
recent
advances
research
focusing
methods,
PFASs,
PBDEs,
PCBs,
OCPs,
pivotal
influence
TTEs.
Studying
elucidated,
providing
support
data
exposure,
transfer,
accumulation
well
theoretical
framework
mechanism
expected
play
vital
role
assessing
impact
pregnant
women
fetuses.
