Numeric uptake drives nanoplastic toxicity: Size-effects uncovered by toxicokinetic-toxicodynamic (TKTD) modeling

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137105 - 137105

Published: Jan. 2, 2025

Language: Английский

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Microplastics in Indonesian land and aquatic environment: From research activities to regulation policies

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 206, P. 116813 - 116813

Published: Aug. 7, 2024

Language: Английский

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In vivo Bioaccumulation and Responses of Hemocytes of Mussels Perna viridis to Microplastics and Nanoplastics Exposure

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135939 - 135939

Published: Sept. 23, 2024

Language: Английский

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In Vivo Visualization of Microplastic Degradability and Intestinal Functional Responses in a Plastivore Insect

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137109 - 137109

Published: Jan. 5, 2025

Language: Английский

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Modeling the Vertical Transport of Copepod Fecal Particles under Nano/Microplastic Exposure

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Nano- and microplastics (NMPs) may significantly impact the marine carbon cycle, fecal pellets produced by copepods are crucial for vertical transport. In this study, we investigated effects of NMP size, concentration, diatom supply on production settling copepod Parvocalanus crassirostris. By employing an aggregation-induced emission fluorescence imaging technique, visualized distribution NMPs in pellets, measured their size rate, developed a fluid dynamic model to simulate process water column. Our results indicated that NPs MPs exhibited uniform nonuniform distributions materials, respectively. reduced both integrity pellets. Copepods ingested absence diatoms, but exposure 5000 μg/L decreased pellet 52% presence diatoms due feeding selectivity. The sinking rates varying sizes, as obtained from modeling simulations, ranged 10.9 103.1 m/day. When proportion participating polystyrene (PS) reached 50%, velocity 34%. study provides new insights into transport under pollution.

Language: Английский

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Marine Micro(nano)plastics Toxicology: Knowledge Gaps and Perspectives

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138086 - 138086

Published: March 1, 2025

Language: Английский

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Passing the Parcels: Intercellular Nanoplastics Transfer in Mussels Perna viridis with Activated Immunomodulation

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Nanoplastics (NPs) are generally considered to have a defined intracellular fate, being difficult excrete or transport due their stability. This study provides the first evidence of NPs intercellular transfer in hemocytes green mussels (Perna viridis), which subsequently activated immunomodulation process. were predominantly internalized by granulocytes, with portion translocated and deposited lysosomes, whereas those retained endosomes transferred new (mainly granulocytes). The direction was driven NP concentration gradients. Transfer kinetics size-dependent, smaller-sized exhibiting greater potential but lower rate, primarily specific extracellular vesicle-mediated pathway. Tunneling nanotubes provided most efficient pathway for NPs, as continuous membrane structure allowed direct substance exchange. Crucially, redistribution accompanied gradient-driven mitochondria injured hemocytes. process alleviated stress on overburdened regulated reactive oxygen species production, enhancing phagocytic activity promoting immune responses. These findings underscore that exhibit far more active behavior system than previously understood provide insights into how cells maintain health marine organisms face challenges.

Language: Английский

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Nanoplastics Transport in Zebrafish Brain: Molecular and Phenotypic Behavioral Impacts

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138548 - 138548

Published: May 1, 2025

Language: Английский

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Modeling the Differential Functional Responses and Selectivity of a Marine Copepod to Nano/Microplastics in Mixture

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135805 - 135805

Published: Sept. 10, 2024

Language: Английский

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Visible Combined Near-Infrared in Situ Imaging Revealed Dynamic Effects of Microplastic Fibers and Beads in Zebrafish

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(37), P. 16269 - 16281

Published: Aug. 30, 2024

Microplastics (MPs) as emerging contaminants are widely present in the environment and ubiquitously ingested accumulated by aquatic organisms. MPs may be quickly eliminated after a brief retention animals (such digestive tract); thus, understanding damage caused during this process whether can recovered is important. Here, we proposed use of visible light imaging to track combined with near-infrared (NIR) reveal

Language: Английский

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