Antibiotics in the global river system arising from human consumption DOI Creative Commons
Heloisa Ehalt Macedo, Bernhard Lehner, Jim A. Nicell

et al.

PNAS Nexus, Journal Year: 2025, Volume and Issue: 4(4)

Published: March 27, 2025

Abstract The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due their toxicity influence on antimicrobial resistance. After consumption partial metabolism, antibiotic residues are excreted undergo complex accumulation decay processes along pathway from wastewater natural river systems. Here, we use a global contaminant fate model estimate that the annual 40 most used (29,200 tonnes), 8,500 tonnes (29%) released into system 3,300 (11%) reach world's oceans or inland sinks. Even when only domestic sources considered (i.e. not including veterinary industrial sources), 6 million km rivers worldwide subject total concentrations excess thresholds protective resistance promotion during low streamflow conditions, with dominant contributors being amoxicillin, ceftriaxone, cefixime. Therefore, it is concern alone represents significant risk for across all continents, largest extents found Southeast Asia. Global has grown rapidly over last 15 years continues increase, particularly low- middle-income countries, requiring new strategies safeguard water quality protect ecosystem health.

Language: Английский

Unraveling the Composition Profile and Ecological Risk of Triazine Herbicides and Their Transformation Products in Urban Sewage Discharge DOI

Yingying Yang,

Qing Zhang, Adrian Covaci

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Triazine herbicides (THs) are used globally to control weeds in urban environments, but their transformation products (TPs) rarely considered due the lack of reference standards. In this study, a total 41 TPs were found wastewater influents and effluents 28 municipal treatment plants (MWWTPs) from six cities China by integrating suspect screening (36 TPs), molecular networking (9 diagnostic fragment searching (12 TPs). Among these, 36 detected for first time aquatic reported environments. Polar THs only partially removed aqueous phase process. Concentrations present ranged 107 435 ng/L. Thus, discharged pose medium risk freshwater algae receiving waters. Moreover, 4 (ametryne, atrazine, terbutryn, prometryne) 3 (atrazine-desisopropyl, TP247, TP258) significant risks several effluents. Considering persistent mobile properties ecological TPs, these contaminants should be specifically further environmental monitoring included regulation.

Language: Английский

Citations

0
Transformation products of antibiotics: overlooked drivers for enhancing the environmental spread of antibiotic resistance DOI Open Access

Yuan Zhang,

Jiayan Jiang, Mingbao Feng

et al.

Journal of Environmental Exposure Assessment, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 10, 2025

Humans have released thousands of antibiotics into the environment, which is a primary driver global dissemination bacterial resistance. Parent compounds can generate various transformation products (TPs), many remain unidentified and lack comprehensive microbial risk assessments. The TPs formed during process may exhibit structural similarities to parent compounds, they induce antibiotic-like resistance transmission despite lacking bactericidal/antibacterial properties compounds. However, assessments antimicrobial hazards predominantly emphasize while largely neglecting their TPs. Here, we highlight that warrant greater attention regarding chemical structure identification transmission. This perspective summarizes TPs’ potential, mechanisms, challenges in triggering

Language: Английский

Citations

0
Unveiling the overlooked silent threat: High-throughput suspect screening of antibiotics and multidimensional heterogeneity in aquatic ecosystems of megacity DOI
Tong Guo,

Qin Yan Yue,

Yu Hou

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138193 - 138193

Published: April 1, 2025

Language: Английский

Citations

0
Unveiling the mechanism and driving factors of pharmaceutical and personal care product (PPCP) removal in wastewater treatment plants DOI
S. Li,

Zhen Gao,

Tianyi Chen

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 383, P. 125358 - 125358

Published: April 21, 2025

Language: Английский

Citations

0
Antibiotics in the global river system arising from human consumption DOI Creative Commons
Heloisa Ehalt Macedo, Bernhard Lehner, Jim A. Nicell

et al.

PNAS Nexus, Journal Year: 2025, Volume and Issue: 4(4)

Published: March 27, 2025

Abstract The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due their toxicity influence on antimicrobial resistance. After consumption partial metabolism, antibiotic residues are excreted undergo complex accumulation decay processes along pathway from wastewater natural river systems. Here, we use a global contaminant fate model estimate that the annual 40 most used (29,200 tonnes), 8,500 tonnes (29%) released into system 3,300 (11%) reach world's oceans or inland sinks. Even when only domestic sources considered (i.e. not including veterinary industrial sources), 6 million km rivers worldwide subject total concentrations excess thresholds protective resistance promotion during low streamflow conditions, with dominant contributors being amoxicillin, ceftriaxone, cefixime. Therefore, it is concern alone represents significant risk for across all continents, largest extents found Southeast Asia. Global has grown rapidly over last 15 years continues increase, particularly low- middle-income countries, requiring new strategies safeguard water quality protect ecosystem health.

Language: Английский

Citations

0