ACS ES&T Water,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Conventional
detection
technologies
for
environmental
contaminants
have
primarily
focused
on
providing
accurate
qualitative
and
quantitative
evaluations
single
pollutant
types,
leading
to
increased
costs
an
inability
satisfy
the
growing
demand
detecting
a
broader
spectrum
of
pollutants.
Here,
we
introduced
novel
analytical
method
simultaneously
measure
concentration
levels
diverse
pollutants,
characterized
by
their
distinct
properties,
across
complex
biological
samples.
Per-
polyfluoroalkyl
substances
(PFAS)
antibiotics
were
used
as
case
study
due
frequency
in
environment
known
impacts
Our
harnesses
salting-out
effect
sodium
chloride
proteins
within
muscle
tissues
178
marine
species,
which
significantly
reduces
addition
extraneous
substances,
mitigates
matrix
interference,
avoids
reliance
solid-phase
extraction
or
dispersive
agents.
The
provides
simultaneous
pretreatment
several
compounds,
with
limits
from
0.002
0.41
ng/g
dry
weight,
are
substantially
lower
than
conventional
methods.
Overall,
this
streamlines
efficiency,
decreases
costs,
lessens
effects,
sets
solid
groundwork
future
applications
concurrent
environmentally
pertinent
pollutants
varied
characteristics.
Environment International,
Journal Year:
2024,
Volume and Issue:
187, P. 108670 - 108670
Published: April 24, 2024
Antibiotics
are
extensively
utilized
in
the
livestock
and
poultry
industry
can
accumulate
animals
environment,
leading
to
potential
health
risks
for
humans
via
food
water
consumption.
Research
on
antibiotic
toxicity,
particularly
their
impact
as
endocrine
disruptors
male
reproductive
system,
is
still
its
nascent
stages.
This
review
highlights
toxic
effect
of
antibiotics
detailing
common
routes
exposure
detrimental
mechanisms
various
classes.
Additionally,
it
discusses
protective
role
food-derived
active
substances
against
toxicity
induced
by
antibiotics.
aims
raise
awareness
about
males
outline
challenges
that
must
be
addressed
future
research.
Abnormal
development
and
mortality
in
early
life
stages
pose
significant
threats
to
the
growth
continuation
of
fish
populations.
Tris(2,4-di-tert-butylphenyl)
phosphate
(TDtBPP)
is
a
novel
organophosphate
ester
contaminant
detected
natural
waters.
However,
potential
effects
maternal
exposure
TDtBPP
on
offspring
embryos
remain
unknown.
Here,
30-day-old
zebrafish
were
exposed
at
0,
50,
500,
or
5000
ng/L
for
180
days,
females
spawned
with
unexposed
males.
accumulation
was
embryos,
accompanied
by
an
increased
malformation
rate
mortality.
The
developmental
abnormality
identified
originate
from
gastrula
stage.
Furthermore,
based
transcriptome
analysis,
down-regulation
RHO
family
interacting
cell
polarization
regulator
2
gene
(ripor2)
considered
as
key
toxic
event,
this
confirmed
subsequent
knockdown
experiment.
Moreover,
molecular
docking
studies
forkhead
box
O1
(foxO1)
transcription
factor
inhibitor
(AS1842856)
experiments
demonstrated
that
blockade
foxO1
transcriptional
regulation
responsible
decreased
expression
ripor2.
results
study
occurrence
following
triggered
consequent
Aquaculture Research,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Antibiotics
are
extensively
used
in
aquaculture
to
treat
and
prevent
bacterial
diseases,
but
their
application
can
lead
negative
side
effects
such
as
immunosuppression.
Oxytetracycline
(OTC)
is
a
widely
antibiotic
for
treating
diseases
due
its
broad‐spectrum
activity
economic
advantage.
This
study
appraises
the
of
OTC
treatment
on
immune
response
European
sea
bass
(
Dicentrarchus
labrax
,
L.
1758)
by
assessing
immune‐related
gene
expression,
serological
parameters,
hematological
histological
findings.
Fish
were
divided
into
three
groups:
control
(fed
with
nonsupplemented
OTC),
75
mg
kg
−1
day
feed,
100
feed
21
days.
Blood
tissue
samples
collected
analysis
4th,
7th,
10th,
14th,
21st
feeding.
The
results
showed
decrease
parameters
nitro
blue
tetrazolium
(NBT)
positive
cell,
total
white
blood
cells
(WBCs),
serum
lysozyme
activity,
Ig‐M
levels,
complement
OTC‐fed
fish,
while
genes
Lys-g
Ig-M
interleukin
IL
)‐
1β
C3
major
histocompatibility
complex
[
MHC
]
–IIα
)
significantly
downregulated
kidney
spleen
tissues,
especially
prolonged
exposure.
hypothesized
that
long‐term
use
antibiotics
fish
disrupts
functioning
system.
As
result
study,
hypothesis
was
confirmed,
using
longer
than
normal
period
or
high
doses
caused
changes
system
made
more
susceptible
other
pathogens.
Expert Review of Vaccines,
Journal Year:
2024,
Volume and Issue:
23(1), P. 535 - 545
Published: April 26, 2024
Zebrafishes
represent
a
proven
model
for
human
diseases
and
systems
biology,
exhibiting
physiological
genetic
similarities
having
innate
adaptive
immune
systems.
However,
they
are
underexplored
vaccinology,
vaccine
development,
testing.
Here
we
summarize
gaps
challenges.
