Far from Their Origins: A Transcriptomic Investigation on How 2,4‐Di‐tert‐butyl‐6‐(5‐chloro‐2H‐benzotriazol‐2‐yl) Phenol Affects Rainbow Trout Alevins DOI Creative Commons
Andreas N. M. Eriksson, Justin Dubiel, Alper James Alcaraz

et al.

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(9), P. 2026 - 2038

Published: June 25, 2024

Benzotriazole ultraviolet stabilizers (BUVSs) are a group of widely used chemicals added to variety consumer (e.g., plastics) and industrial metal coating) goods. Although detected globally as an environmentally persistent pollutant, BUVSs have received relatively little toxicological attention only recently been acknowledged affect development the endocrine system in vivo. In our previous study, altered behavior, indicative potential neurotoxicity, was observed among rainbow trout alevins (day 14 posthatching) that were microinjected embryos with single relevant dose 2,4-di-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl) phenol (UV-327). present follow-up we performed whole-transcriptome profiling (RNA sequencing) newly hatched from same batch. The primary aim identify biomarkers related behavior neurology. Dose-specifically, 1 176 differentially expressed genes (DEGs) identified. presenting (273.4 ng g

Language: Английский

Effects of benzotriazoles UV-328, UV-329, and UV-P on the self-renewal and adipo-osteogenic differentiation of human mesenchymal stem cells DOI Creative Commons
Yue Zhang, Hui Zhao,

Qianxi Feng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117765 - 117765

Published: Jan. 1, 2025

Language: Английский

Citations

0
Scant Evidence for Long-Range Atmospheric Transport of Particle-Bound Benzotriazole Ultraviolet Stabilizers DOI
Chubashini Shunthirasingham, Faqiang Zhan,

Milena Rabu

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Despite benzotriazole UV stabilizers (BT-UVs) being widely used since the 1960s, few empirical data on their atmospheric presence exist. UV-328 was added to Stockholm Convention Persistent Organic Pollutants, based in part model calculations indicating long-range transport potential. We investigated occurrence of BT-UVs at multiple sites that differ greatly proximity potential sources. UV-P, UV-328, UV-234, UV-326, UV-329, and UV-327 were quantified active air samples collected suburban Toronto, Saturna Island Salish Sea, Point Petre Lake Ontario, Alert, Nunavut, as well XAD-resin passive samplers deployed British Columbia Quebec. As most volatile BT-UV, UV-P present gas phase across all sampling locations, with higher concentrations urban areas. The five less only from Toronto not found above detection limits (0.03–1.7 pg·m–3) anywhere else. Empirical evidence thus does support predictions particle-bound BT-UVs. Predictions simple should be supported by if they are basis for regulatory decisions.

Language: Английский

Citations

0
Insights into the effect of benzotriazoles in liver using integrated metabolomic and transcriptomic analysis DOI Creative Commons

Ze‐Qin Guo,

Huimin Li, Wenmin Yu

et al.

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108716 - 108716

Published: May 1, 2024

Benzotriazoles (BTRs) are a class of benzoheterocyclic chemicals that frequently used as metal-corrosive inhibitors, both in industry and daily use. However, the exposure effect information on BTRs remains relatively limited. In this study, an integrated metabolomic transcriptomic approach was utilized to evaluate three BTRs, benzotriazole, 6-chloro-1-hydroxi-benzotriazole, 1-hydroxy-benzotriazole, mouse liver with results showing disrupted basal metabolic processes vitamin cofactor metabolism after 28 days. The expression several genes related inflammatory response aryl hydrocarbon receptor pathways, such Gstt2 Arntl, altered by BTRs. Exposure also affected metabolites involved immune system xenobiotic responses. cytochrome P450 family reveal potential detoxification mechanism liver. Taken together, our findings provide new insights into multilayer well resource for further exploration molecular mechanisms which occurs.

Language: Английский

Citations

3
Benzotriazole ultraviolet absorbents in surface waters and sediments of the Bohai Sea and North Yellow Sea: Spatial trends and influencing factors DOI
Xing Liu,

Zilan Wu,

Xiaodan Pei

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 174264 - 174264

Published: June 25, 2024

Language: Английский

Citations

2
Unravelling structural features of small molecules for photochemical transformation of environmental contaminants DOI
Hongcen Zheng, Guoyang Zhang, Chengyang Zhang

et al.

Water Research, Journal Year: 2024, Volume and Issue: 261, P. 122015 - 122015

Published: June 28, 2024

Language: Английский

Citations

1
New Insights into the Visual Toxicity of Organophosphate Esters: An Integrated Quantitative Adverse Outcome Pathway and Cross-chemical Extrapolation DOI
Ning Gao, Lanpeng Yang, Lingyan Zhu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Organophosphate esters (OPEs) have been documented to adversely affect visual function, potentially impacting wildlife survival and human health, thereby necessitating a comprehensive risk assessment. Despite the quantitative adverse outcome pathway (qAOP) holding promise for addressing this concern mechanistically, unclear mode of action inadequate understanding across biological levels currently impede its development. Herein, we employed an integrated strategy, combining multiomics analyses, targeted bioassays, modular model-fitting, develop validate qAOP framework toxicity OPEs, exemplified by tris(2-butoxyethyl) phosphate, triphenyl tris(1,3-dichloro-2-propyl) phosphate. Our results revealed that these OPEs induce dysfunction in zebrafish larvae primarily via oxidative stress, then cascade damaging photoreceptors retinal structures, ultimately resulting disruption behaviors (i.e., decreased optokinetic response, phototaxis, motor response). The qAOP, validated through cross-chemical extrapolation, enabled prediction vision-related effects within certain domain. Integrating toxicokinetic modeling could compensate uncertainty predictions, since adjusting internal concentrations as inputs significantly enhanced accuracy applicability predictions. This work contributes better presents promising paradigm assessment based on framework.

Language: Английский

Citations

1
Far from Their Origins: A Transcriptomic Investigation on How 2,4‐Di‐tert‐butyl‐6‐(5‐chloro‐2H‐benzotriazol‐2‐yl) Phenol Affects Rainbow Trout Alevins DOI Creative Commons
Andreas N. M. Eriksson, Justin Dubiel, Alper James Alcaraz

et al.

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(9), P. 2026 - 2038

Published: June 25, 2024

Benzotriazole ultraviolet stabilizers (BUVSs) are a group of widely used chemicals added to variety consumer (e.g., plastics) and industrial metal coating) goods. Although detected globally as an environmentally persistent pollutant, BUVSs have received relatively little toxicological attention only recently been acknowledged affect development the endocrine system in vivo. In our previous study, altered behavior, indicative potential neurotoxicity, was observed among rainbow trout alevins (day 14 posthatching) that were microinjected embryos with single relevant dose 2,4-di-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl) phenol (UV-327). present follow-up we performed whole-transcriptome profiling (RNA sequencing) newly hatched from same batch. The primary aim identify biomarkers related behavior neurology. Dose-specifically, 1 176 differentially expressed genes (DEGs) identified. presenting (273.4 ng g

Language: Английский

Citations

0